Meera Pratap, Ph.D., Researcher in Neurobiology publishes NATURE article on, “Antisense oligonucleotide therapy for spinocerebellar ataxia type 2.” Nature, April 20, 2017, http://www.nature.com/nature/journal/v544/n7650/abs/nature22044.html
New research by scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA overturns a long-standing paradigm about how axons — thread-like projections that connect cells in the nervous system — grow during embryonic development. The findings of the study, led by Samantha Butler, Associate Professor of Neurobiology, could help scientists replicate or control the way axons grow, which may be applicable for diseases that affect the nervous system, such as diabetes, as well as injuries that sever nerves. See journal Neuron, April 20, 2017 issue.
Arnold “Arne” Scheibel was born in New York City in 1923 where he lived for the first 24 years of his life. He did his undergraduate work at Columbia College and received his Doctor of Medicine degree from Columbia College of Physicians and Surgeons in 1946. Though initially interested in cardiology, Dr. Schiebel perceived an apparent pervasiveness of emotional factors in cardiac disease patterns. This led him to the field of psychiatry. After a year of psychiatric residency training at Washington University in St. Louis, he entered the Army as a medical officer and received further training while on active service at Brooke General Hospital in San Antonio.
Increasingly troubled by the lack of knowledge about brain substrates of psychiatric syndromology, Scheibel joined the neurophysiology laboratory of Warren McCulloch at Illinois Neuropsychiatric Institute to learn something about brain structure and function. Here, for the first time, he read some of the work of Camillo Golgi and Santiago Ramon y Cajal and discovered the structural beauty of the central nervous system as revealed by the silver chromate methods of Golgi. Today, more than half a century later, although largely superseded by more discriminative techniques, the Golgi still remains the “gold standard” against which all neurohistological techniques are measured.
After a short period as faculty member at the University of Tennessee and 15 months spent abroad (Universities of Pisa and Oslo) on a Guggenheim fellowship, Scheibel joined the faculty of the University of California at Los Angeles as a member of the departments of anatomy and psychiatry (1955).
Intrigued by the emotional factors that play a role in diseases, Dr. Scheibel focused his research around his interests in both psychiatry and the neural foundations of behavior. Scheibel’s research, stemming from his interests in both psychiatry and the neural underpinnings of behavior, has revolved about the structuro-functional basis of cognition and action. Using both neurohistological and neurophysiological techniques, his laboratory has studied the reticular core of the brain stem and thalamus, the organization of neural modules, structural correlates of aging and psychosis, and the relation between levels of cognitive activity and the patterns and richness of neuropil.
Scheibel had the privilege of serving as Acting Director (1987-1990) and Director (1990-1995) of the Brain Research Institute during a period of economic stress — a period in which the continued existence of the institute itself was under question. Despite this, Scheibel’s leadership kept the BRI alive, and led to innovative programs including a system of affinity groups — working groups that meet regularly to discuss crosscutting topics. Since inception, these affinity groups have resulted in the submission and funding of several training program and program project grants, including the one that created the Alzheimer’s Disease Center. In turn, affinity groups have led to Integrative Centers of Neuroscience Excellence. These centers provide a more formal, cohesive identity and organizational structure that facilitates collaborations and interactions amongst a large community of researchers from disciplines across campus, including faculty, post-doctoral fellows and graduate students..
“Under Dr. Scheibel’s leadership, the BRI flourished and became more integrated into the UCLA community,” said Dr. Christopher J. Evans, director of the BRI. “His contributions included advancing the BRI’s mission to pursue collaborative breakthroughs in understanding the brain and to communicate the excitement of neuroscience to UCLA students and children at local schools.” In addition, during Dr. Scheibel’s time at the BRI, the annual H.W. Magoun Distinguished Lectureship, which recognizes a prominent UCLA neuroscientist, and the annual Samuel Eiduson Student Lectureship, which honors an outstanding neuroscience graduate student, were both initiated.
Scheibel also initiated the student-manned community outreach program, Project Brainstorm — a program that allows UCLA students to teach neuroscience concepts to Los Angeles Unified School District classes, ages K-12.
In 1997, Dr. Scheibel was honored with the Distinguished Teaching Award.
Among other honors, he was elected to the American Academy of Arts and Sciences.
Last year, as memorial tributes to his parents, Scheibel established the Ethel Scheibel Endowed Chair in Neuroscience in the Department of Neurobiology at the David Geffen School of Medicine, and the William Scheibel Endowed Chair in Neuroscience at UCLA’s Brain Research Institute
You ca read about Arne, in his owe words here: https://www.sfn.org/~/media/SfN/Documents/TheHistoryofNeuroscience/Volume%205/c15.ashx