Jerome Engel, Jr., MD, PhD, is Director of the Seizure Disorder Center, The Jonathan Sinay Distinguished Professor of Neurology, Neurobiology, and Psychiatry and Biobehavioral Sciences, and a member of the Brain Research Institute at UCLA. He received his undergraduate degree from Cornell University, his advanced degrees from Stanford University, and completed his training in neurology at Albert Einstein College of Medicine. Dr. Engel is past president of the American Clinical Neurophysiology Society , the American Epilepsy Society , and the International League against Epilepsy, and is past co-chair of the Global Campaign against Epilepsy. His bibliography lists over 1,000 publications and over 30 books, including Epilepsy: A Comprehensive Textbook, Surgical Treatment of the Epilepsies, The Treatment of Epilepsy, and Seizures and Epilepsy. He is principal investigator on three research grants from the National Institute of Neurological Disorders and Stroke, and has received numerous awards and honors, including a Fulbright Scholarship, a Guggenheim Fellowship, a Javits Award, and the Life-Time Achievement Award from the International League against Epilepsy.
PUBLICATIONS
Haneef Zulfi, Chiang Sharon, Yeh Hsiang J, Engel Jerome, Stern John M Functional connectivity homogeneity correlates with duration of temporal lobe epilepsy Epilepsy & behavior : E&B, 2015; 46(2): 227-33.Memarian Negar, Madsen Sarah K, Macey Paul M, Fried Itzhak, Engel Jerome, Thompson Paul M, Staba Richard J Ictal depth EEG and MRI structural evidence for two different epileptogenic networks in mesial temporal lobe epilepsy PloS one, 2015; 10(4): e0123588.Jobst Barbara C, Engel Jerome Is it time to replace epileptic spikes with fast ripples? Neurology, 2015; 85(2): 114-5.Memarian Negar, Kim Sally, Dewar Sandra, Engel Jerome, Staba Richard J Multimodal data and machine learning for surgery outcome prediction in complicated cases of mesial temporal lobe epilepsy Computers in biology and medicine, 2015; 64: 67-78.Dewar Sandra, Eliashiv Dawn, Walshaw Patricia D, Engel Jerome, Fried Itzhak, Moseley Brian D Safety, efficacy, and life satisfaction following epilepsy surgery in patients aged 60 years and older Journal of neurosurgery, 2015; 1-7.Chiang Sharon, Stern John M, Engel Jerome, Haneef Zulfi Structural-functional coupling changes in temporal lobe epilepsy Brain research, 2015; 1616: 45-57.Jehi Lara, Friedman Daniel, Carlson Chad, Cascino Gregory, Dewar Sandra, Elger Christian, Engel Jerome, Knowlton Robert, Kuzniecky Ruben, McIntosh Anne, O’Brien Terence J, Spencer Dennis, Sperling Michael R, Worrell Gregory, Bingaman Bill, Gonzalez-Martinez Jorge, Doyle Werner, French Jacqueline The evolution of epilepsy surgery between 1991 and 2011 in nine major epilepsy centers across the United States, Germany, and Australia Epilepsia, 2015; 1616: .Korczyn Amos D, Schachter Steven C, Amlerova Jana, Bialer Meir, van Emde Boas Walter, Brázdil Milan, Brodtkorb Eylert, Engel Jerome, Gotman Jean, Komárek Vladmir, Leppik Ilo E, Marusic Petr, Meletti Stefano, Metternich Birgitta, Moulin Chris J A, Muhlert Nils, Mula Marco, Nakken Karl O, Picard Fabienne, Schulze-Bonhage Andreas, Theodore William, Wolf Peter, Zeman Adam, Rektor Ivan Third International Congress on Epilepsy, Brain and Mind: Part 1 Epilepsy & behavior : E&B, 2015; 50: 116-37.Engel Jerome Who will use epilepsy surgery nomograms, and why? The Lancet. Neurology, 2015; 14(3): 240-1.Engel Jerome Approaches to refractory epilepsy Annals of Indian Academy of Neurology, 2014; 17(Suppl 1): S12-7.Chiang Sharon, Stern John M, Engel Jerome, Levin Harvey S, Haneef Zulfi Differences in graph theory functional connectivity in left and right temporal lobe epilepsy Epilepsy research, 2014; 108(10): 1770-81.Engel Jerome, Dichter Marc A Epilepsy. Foreword Advances in experimental medicine and biology, 2014; 813(Suppl 1): v-xiii.Bragin Anatol, Almajano Joel, Kheiri Farshad, Engel Jerome Functional connectivity in the brain estimated by analysis of gamma events PloS one, 2014; 9(1): e85900.Haneef Zulfi, Lenartowicz Agatha, Yeh Hsiang J, Levin Harvey S, Engel Jerome, Stern John M Functional connectivity of hippocampal networks in temporal lobe epilepsy Epilepsia, 2014; 55(1): 137-45.Del Brutto Oscar H, Engel Jerome, Eliashiv Dawn S, Salamon Noriko, GarcÃa Hector H Hippocampal sclerosis: the missing link of cysticercosis epileptogenesis? Epilepsia, 2014; 55(12): 2077-8.Fisher Robert S, Acevedo Carlos, Arzimanoglou Alexis, Bogacz Alicia, Cross J Helen, Elger Christian E, Engel Jerome, Forsgren Lars, French Jacqueline A, Glynn Mike, Hesdorffer Dale C, Lee B I, Mathern Gary W, Moshé Solomon L, Perucca Emilio, Scheffer Ingrid E, Tomson Torbjörn, Watanabe Masako, Wiebe Samuel ILAE official report: a practical clinical definition of epilepsy Epilepsia, 2014; 55(4): 475-82.Kerr Wesley T, Hwang Eric S, Raman Kaavya R, Barritt Sarah E, Patel Akash B, Le Justine M, Hori Jessica M, Davis Emily C, Braesch Chelsea T, Janio Emily A, Lau Edward P, Cho Andrew Y, Anderson Ariana, Silverman Daniel H S, Salamon Noriko, Engel Jerome, Stern John M, Cohen Mark S Multimodal diagnosis of epilepsy using conditional dependence and multiple imputation … International Workshop on Pattern Recognition in NeuroImaging. International Workshop on Pattern Recognition in Neuroimaging, 2014; 55(6): 1-4.Haneef Zulfi, Lenartowicz Agatha, Yeh Hsiang J, Engel Jerome, Stern John M Network analysis of the default mode network using functional connectivity MRI in Temporal Lobe Epilepsy Journal of visualized experiments : JoVE, 2014; 13(90): e51442.Pitkänen Asla, Engel Jerome Past and present definitions of epileptogenesis and its biomarkers Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2014; 11(2): 231-41.Savic Ivanka, Engel Jerome Structural and functional correlates of epileptogenesis – does gender matter? Neurobiology of disease, 2014; 70(10): 69-73.Simonato Michele, Brooks-Kayal Amy R, Engel Jerome, Galanopoulou Aristea S, Jensen Frances E, Moshé Solomon L, O’Brien Terence J, Pitkanen Asla, Wilcox Karen S, French Jacqueline A The challenge and promise of anti-epileptic therapy development in animal models The Lancet. Neurology, 2014; 13(9): 949-60.Dedeurwaerdere Stefanie, Shultz Sandy R, Federico Paolo, Engel Jerome Workshop on Neurobiology of Epilepsy appraisal: new systemic imaging technologies to study the brain in experimental models of epilepsy Epilepsia, 2014; 55(6): 819-28.Engel Jerome, Thompson Paul M, Stern John M, Staba Richard J, Bragin Anatol, Mody Istvan Connectomics and epilepsy Current opinion in neurology, 2013; 26(2): 186-94.Engel Jerome, Pitkänen Asla, Loeb Jeffrey A, Dudek F Edward, Bertram Edward H, Cole Andrew J, Moshé Solomon L, Wiebe Samuel, Jensen Frances E, Mody Istvan, Nehlig Astrid, Vezzani Annamaria Epilepsy biomarkers Epilepsia, 2013; 54 Suppl 4(5): 61-9.Rektor Ivan, Schachter Steven C, Arzy Shahar, Baloyannis Stavros J, Bazil Carl, Brázdil Milan, Engel Jerome, Helmstaedter Gerhard, Hesdorffer Dale C, Jones-Gotman Marilyn, Kesner Ladislav, Komárek VladimÃr, Krämer Günter, Leppik Ilo E, Mann Michael W, Mula Marco, Risse Gail L, Stoker Guy W, Kasteleijn-Nolst Trenité Dorothée G A, Trimble Michael, Tyrliková Ivana, Korczyn Amos D Epilepsy, behavior, and art (Epilepsy, Brain, and Mind, part 1) Epilepsy & behavior : E&B, 2013; 28(2): 261-82.Korczyn Amos D, Schachter Steven C, Brodie Martin J, Dalal Sarang S, Engel Jerome, Guekht Alla, Hecimovic Hrvoje, Jerbi Karim, Kanner Andres M, Johannessen Landmark Cecilie, Mares Pavel, Marusic Petr, Meletti Stefano, Mula Marco, Patsalos Philip N, Reuber Markus, Ryvlin Philippe, Å tillová Klára, Tuchman Roberto, Rektor Ivan Epilepsy, cognition, and neuropsychiatry (Epilepsy, Brain, and Mind, part 2) Epilepsy & behavior : E&B, 2013; 28(2): 283-302.Kheiri Farshad, Bragin Anatol, Engel Jerome Functional connectivity between brain areas estimated by analysis of gamma waves Journal of neuroscience methods, 2013; 214(2): 184-91.Burneo Jorge G, Sirven Joseph I, Kiesel Lily Wong, Vecht Charles J, Jehi Lara, Chung Steve S, Uhm Joon, Politsky Jeffrey M, Chang Edward F, Husain Aatif M, Tatum William O, Meador Kimford J, Noe Katherine, Hesdorffer Dale C, Herman Susan T, Wiebe Samuel, Engel Jerome, Schrader Sara, Parko Karen L, Dichter March A, Kwan Patrick, Kossoff Eric, Sperling Michael R Managing common complex symptomatic epilepsies: tumors and trauma: american epilepsy society – 2012 annual course summary Epilepsy currents / American Epilepsy Society, 2013; 13(5): 232-5.Engel Jerome Progress in the field of epilepsy Current opinion in neurology, 2013; 26(2): 160-2.Memarian Negar, Thompson Paul M, Engel Jerome, Staba Richard J Quantitative analysis of structural neuroimaging of mesial temporal lobe epilepsy Imaging in medicine, 2013; 5(3): .Alvarado-Rojas Catalina, Lehongre Katia, Bagdasaryan Juliana, Bragin Anatol, Staba Richard, Engel Jerome, Navarro Vincent, Le Van Quyen Michel Single-unit activities during epileptic discharges in the human hippocampal formation Frontiers in computational neuroscience, 2013; 7(2): 140.Engel Jerome, McDermott Michael P, Wiebe Samuel, Langfitt John T, Stern John M, Dewar Sandra, Sperling Michael R, Gardiner Irenita, Erba Giuseppe, Fried Itzhak, Jacobs Margaret, Vinters Harry V, Mintzer Scott, Kieburtz Karl, Kieburtz Karl Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial JAMA : the journal of the American Medical Association, 2012; 307(9): 922-30.Haneef Zulfi, Lenartowicz Agatha, Yeh Hsiang J, Engel Jerome, Stern John M Effect of lateralized temporal lobe epilepsy on the default mode network Epilepsy & behavior : E&B, 2012; 25(3): 350-7.Simonato Michele, Löscher Wolfgang, Cole Andrew J, Dudek F Edward, Engel Jerome, Kaminski Rafal M, Loeb Jeffrey A, Scharfman Helen, Staley Kevin J, VelÃÅ¡ek Libor, Klitgaard Henrik Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design Epilepsia, 2012; 53(11): 1860-7.Engel Jerome, Thompson Paul M Going beyond hippocampocentricity in the concept of mesial temporal lobe epilepsy Epilepsia, 2012; 53(1): 220-3.Staba Richard J, Ekstrom Arne D, Suthana Nanthia A, Burggren Alison, Fried Itzhak, Engel Jerome, Bookheimer Susan Y Gray matter loss correlates with mesial temporal lobe neuronal hyperexcitability inside the human seizure-onset zone Epilepsia, 2012; 53(1): 25-34.Engel Jerome, da Silva Fernando Lopes High-frequency oscillations – Where we are and where we need to go Progress in neurobiology, 2012; 53(3): .Galanopoulou Aristea S, Buckmaster Paul S, Staley Kevin J, Moshé Solomon L, Perucca Emilio, Engel Jerome, Löscher Wolfgang, Noebels Jeffrey L, Pitkänen Asla, Stables James, White H Steve, O’Brien Terence J, Simonato Michele, Simonato Michele Identification of new epilepsy treatments: issues in preclinical methodology Epilepsia, 2012; 53(3): 571-82.Kheiri Farshad, Bragin Anatol, Engel Jerome Jr, Almajano Joel, Winden Eamon Non-linear classification of heart rate parameters as a biomarker for epileptogenesis Epilepsy research, 2012; 100(1-2): 59-66.Bateman Lisa M, Begley Charles E, Ben-Menachem Elinor, Berg Anne T, Berkovic Samuel F, Cascino Gregory D, Drazkowski Joseph, Edwards Jonathan C, Engel Jerome, French Jacqueline A, Gilliam Frank D, Hoerth Matthew T, Jehi Lara E, Kanner Andres M, Krauss Gregory L, Labiner David M, Loddenkemper Tobias, Luders Hans O, McKhann Guy M, McLachlan Richard, Modi Avani, Pennell Page B, Shafer Patricia O, Sirven Joseph I, Stern John M, Szaflarski Jerzy P, Theodore William H Overcoming barriers to successful epilepsy management Epilepsy currents / American Epilepsy Society, 2012; 12(4): 158-60.Engel Jerome, Wiebe Samuel Who is a surgical candidate? Handbook of clinical neurology, 2012; 108(4): 821-8.Winden Kellen D, Karsten Stanislav L, Bragin Anatol, Kudo Lili C, Gehman Lauren, Ruidera Josephine, Geschwind Daniel H, Engel Jerome A systems level, functional genomics analysis of chronic epilepsy PloS one, 2011; 6(6): e20763.Engel Jerome Another good reason to consider surgical treatment for epilepsy more often and sooner Archives of neurology, 2011; 68(6): 707-8.Engel Jerome Biomarkers in epilepsy: introduction Biomarkers in medicine, 2011; 5(5): 537-44.Cendes Fernando, Engel Jerome Extending applications for high-frequency oscillations: the ripple effect Neurology, 2011; 77(6): 518-9.Bragin Anatol, Benassi Simone K, Kheiri Farshad, Engel Jerome Further evidence that pathologic high-frequency oscillations are bursts of population spikes derived from recordings of identified cells in dentate gyrus Epilepsia, 2011; 52(1): 45-52.Engel Jerome The etiologic classification of epilepsy Epilepsia, 2011; 52(6): 1195-7; discussion 1205-9.Fisher Robert S, Engel Jerome J Definition of the postictal state: when does it start and end? Epilepsy & behavior : E&B, 2010; 19(2): 100-4.Engel Jerome, McDermott Michael P, Wiebe Samuel, Langfitt John T, Erba Giuseppe, Gardiner Irenita, Stern John, Dewar Sandra, Sperling Michael R, Jacobs Margaret, Kieburtz Karl, Kieburtz Karl Design considerations for a multicenter randomized controlled trial of early surgery for mesial temporal lobe epilepsy Epilepsia, 2010; 51(10): 1978-86.Wilson Sarah J, Engel Jerome Diverse perspectives on developments in epilepsy surgery Seizure : the journal of the British Epilepsy Association, 2010; 19(10): 659-68.Engel Jerome Do we belittle epilepsy by calling it a disorder rather than a disease? Epilepsia, 2010; 51(11): 2363-4.Upchurch Kristen, Stern John M, Salamon Noriko, Dewar Sandra, Engel Jerome, Vinters Harry V, Fried Itzhak Epileptogenic temporal cavernous malformations: operative strategies and postoperative seizure outcomes Seizure : the journal of the British Epilepsy Association, 2010; 19(2): 120-8.Bragin Anatol, Engel Jerome, Staba Richard J High-frequency oscillations in epileptic brain Current opinion in neurology, 2010; 23(2): 151-6.He De Fu, Ma Dong Liang, Tang Yong Cheng, Engel Jerome, Bragin Anatol, Tang Feng Ru Morpho-physiologic characteristics of dorsal subicular network in mice after pilocarpine-induced status epilepticus Brain pathology (Zurich, Switzerland), 2010; 20(1): 80-95.Engel Jerome, Akhtari Massoud, Bragin Anatol, Fried Itzhak, Ogren Jennifer A, Staba Richard J, Salamon Noriko, Thompson Paul M New approaches to structural and functional imaging in focal epilepsy Epilepsia, 2010; 51 Suppl 1(2): 83-6.Haneef Zulfi, Stern John, Dewar Sandra, Engel Jerome Referral pattern for epilepsy surgery after evidence-based recommendations: a retrospective study Neurology, 2010; 75(8): 699-704.Lerner Jason T, Salamon Noriko, Hauptman Jason S, Velasco Tonicarlo R, Hemb Marta, Wu Joyce Y, Sankar Raman, Donald Shields W, Engel Jerome, Fried Itzhak, Cepeda Carlos, Andre Veronique M, Levine Michael S, Miyata Hajime, Yong William H, Vinters Harry V, Mathern Gary W Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience Epilepsia, 2009; 50(6): 1310-35.Engel Jerome, Moshé Solomon L Commentary: hormones, diet, and botanicals Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2009; 6(2): 421-3.Engel Jerome, Bragin Anatol, Staba Richard, Mody Istvan High-frequency oscillations: what is normal and what is not? Epilepsia, 2009; 50(4): 598-604.Engel Jerome The ILAE –where it was, and where it is going: a personal view Epilepsia, 2009; 50(3): 343-5.Bragin Anatol, Azizyan Avetis, Almajano Joyel, Engel Jerome The cause of the imbalance in the neuronal network leading to seizure activity can be predicted by the electrographic pattern of the seizure onset The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(11): 3660-71.Ogren Jennifer A, Bragin Anatol, Wilson Charles L, Hoftman Gil D, Lin Jack J, Dutton Rebecca A, Fields Tony A, Toga Arthur W, Thompson Paul M, Engel Jerome, Staba Richard J Three-dimensional hippocampal atrophy maps distinguish two common temporal lobe seizure-onset patterns Epilepsia, 2009; 50(6): 1361-70.Ogren Jennifer A, Wilson Charles L, Bragin Anatol, Lin Jack J, Salamon Noriko, Dutton Rebecca A, Luders Eileen, Fields Tony A, Fried Itzhak, Toga Arthur W, Thompson Paul M, Engel Jerome, Staba Richard J Three-dimensional surface maps link local atrophy and fast ripples in human epileptic hippocampus Annals of neurology, 2009; 66(6): 783-91.Le Van Quyen M, Bragin A, Staba R, Crepon B, Wilson CL, Engel J Jr. Cell type-specific firing during ripple oscillations in the hippocampal formation of humans, J Neurosci, 2008; 28(24): 6104-10.Le Van Quyen Michel, Bragin Anatol, Staba Richard, Crépon Benoit, Wilson Charles L, Engel Jerome Cell type-specific firing during ripple oscillations in the hippocampal formation of humans The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008; 28(24): 6104-10.Akhtari Massoud, Bragin Anatol, Cohen Mark, Moats Rex, Brenker Frank, Lynch Mattew D, Vinters Harry V, Engel Jerome Functionalized magnetonanoparticles for MRI diagnosis and localization in epilepsy Epilepsia, 2008; 49(8): 1419-30.Akhtari M, Bragin A, Cohen M, Moats R, Brenker F, Lynch MD, Vinters HV, Engel J JR. Functionalized magnetonanoparticles for MRI diagnosis and localization in epilepsy, Epilepsia, 2008; 49(8): 1419-30.Engel Jerome More on the history of temporal lobe surgery Epilepsia, 2008; 49(8): 1481-2.Engel Jerome Progress in epilepsy: reducing the treatment gap and the promise of biomarkers Current opinion in neurology, 2008; 21(2): 150-4.Engel Jerome Surgical treatment for epilepsy: too little, too late? JAMA : the journal of the American Medical Association, 2008; 300(21): 2548-50.Bragin A, Claeys P, Vonck K, Van Roost D, Wilson C, Boon P, Engel J Jr. Analysis of Initial Slow Waves (ISWs) at the Seizure Onset in Patients with Drug Resistant Temporal Lobe Epilepsy, Epilepsia, 2007; .Bragin Anatol, Claeys Pieter, Vonck Kristl, Van Roost Dirk, Wilson Charles, Boon Paul, Engel Jerome Analysis of initial slow waves (ISWs) at the seizure onset in patients with drug resistant temporal lobe epilepsy Epilepsia, 2007; 48(10): 1883-94.Avanzini G, Engel J Jr. Dealing with Drug Dependency: A Commentary on ILAE’s Partnership with the Pharmaceutical Industry, Epilepsia, 2007; .Avanzini Giuliano, Engel Jerome Dealing with drug dependency: a commentary on ILAE’s partnership with the pharmaceutical industry Epilepsia, 2007; 48(10): 1821-4.Staba RJ, Frighetto L, Behnke EJ, Mathern GW, Fields T, Bragin A, Ogren J, Fried I, Wilson CL, Engel J Jr. Increased Fast ripple to ripple Ratios Correlate with Reduced Hippocampal Volumes and Neuron Loss in Temporal Lobe Epilepsy Patients, Epilepsia, 2007; 48(11): 2130-2138.Staba Richard J, Frighetto Leonardo, Behnke Eric J, Mathern Gary W, Fields Tony, Bragin Anatol, Ogren Jennifer, Fried Itzhak, Wilson Charles L, Engel Jerome Increased fast ripple to ripple ratios correlate with reduced hippocampal volumes and neuron loss in temporal lobe epilepsy patients Epilepsia, 2007; 48(11): 2130-8.Co JP, Elia M, Engel J Jr, Guerrini R, Mizrahi EM, Moshe SL, Plouin P. Proposal of an algorithm for diagnosis and treatment of neonatal seizures in developing countries, Epilepsia, 2007; 48(6): 1158-64.Co John Patrick T, Elia Maurizio, Engel Jerome, Guerrini Renzo, Mizrahi Eli M, Moshé Solomon L, Plouin Perrine Proposal of an algorithm for diagnosis and treatment of neonatal seizures in developing countries Epilepsia, 2007; 48(6): 1158-64.Lin Jack J, Salamon Noriko, Lee Agatha D, Dutton Rebecca A, Geaga Jennifer A, Hayashi Kiralee M, Luders Eileen, Toga Arthur W, Engel Jerome, Thompson Paul M Reduced neocortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis Cerebral cortex (New York, N.Y. : 1991), 2007; 17(9): 2007-18.Lin JJ, Salamon N, Lee AD, Dutton RA, Geaga JA, Hayashi KM, Luders E, Toga AW, Engel J Jr, Thompson PM. Reduced neocortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis, Cereb Cortex, 2007; 17(9): 2007-18.Bragin A, Wilson CL, Engel J Jr. Voltage depth profiles of high-frequency oscillations after kainic acid-induced status epilepticus, Epilepsia, 2007; 48(Suppl 5): 35-40.Bragin Anatol, Wilson Charles L, Engel Jerome Voltage depth profiles of high-frequency oscillations after kainic acid-induced status epilepticus Epilepsia, 2007; 48 Suppl 5(6): 35-40.Engel J Jr, Berg A, Andermann F, Avanzini G, Berkovic S, Blume W, Dulac O, van Emde Boas, Fejerman N, Plouin P, Scheffer I, Seino M, Williamson P, Wolf P. Are epilepsy classifications based on epileptic syndromes and seizure types outdated?, Epileptic Disord, 2006; 8(2): 159-60.Engel Jerome, Berg Anne, Andermann Frederick, Avanzini Giuliano, Berkovic Samuel, Blume Warren, Dulac Olivier, van Emde Boas Walter, Fejerman Natalio, Plouin Perrine, Scheffer Ingrid, Seino Masakazu, Williamson Peter, Wolf Peter Are epilepsy classifications based on epileptic syndromes and seizure types outdated? Epileptic disorders : international epilepsy journal with videotape, 2006; 8(2): 159-60.Zeitzer JM, Morales-Villagran A, Maidment NT, Behnke EJ, Ackerson LC, Lopez-Rodriguez F, Fried I, Engel J Jr, Wilson CL. Extracellular adenosine in the human brain during sleep and sleep deprivation: an in vivo microdialysis study, Sleep, 2006; 29(4): 455-61.Zeitzer Jamie M, Morales-Villagran Alberto, Maidment Nigel T, Behnke Eric J, Ackerson Larry C, Lopez-Rodriguez Faustino, Fried Itzhak, Engel Jerome, Wilson Charles L Extracellular adenosine in the human brain during sleep and sleep deprivation: an in vivo microdialysis study Sleep, 2006; 29(4): 455-61.Berg Anne T, Engel Jerome Hippocampal atrophy and the prognosis of epilepsy: some answers, more questions Neurology, 2006; 67(1): 12-3.Berg AT, Engel J Jr. Hippocampal atrophy and the prognosis of epilepsy: some answers, more questions, Neurology, 2006; 67(1): 12-3.Engel Jerome ILAE classification of epilepsy syndromes Epilepsy research, 2006; 70 Suppl 1(9): S5-10.Engel J Jr. ILAE classification of epilepsy syndromes, Epilepsy Res, 2006; 70(Suppl 1): S5-10.Engel Jerome Report of the ILAE classification core group Epilepsia, 2006; 47(9): 1558-68.Engel J Jr. Report of the ILAE classification core group, Epilepsia, 2006; 47(9): 1558-68.de Boer HM, Engel J Jr, Prilipko LL. “Out of the shadows”: a partnership that brings progress!, Epilepsia, 2005; 46(Suppl 1): 61-2.Bragin Anatol, Azizyan Avetis, Almajano Joyel, Wilson Charles L, Engel Jerome Analysis of chronic seizure onsets after intrahippocampal kainic acid injection in freely moving rats Epilepsia, 2005; 46(10): 1592-8.Bragin A, Azizyan A, Almajano J, Wilson CL, Engel J Jr. Analysis of chronic seizure onsets after intrahippocampal kainic acid injection in freely moving rats, Epilepsia, 2005; 46(10): 1592-8.Bragin A, Wilson CL, Fields T, Fried I, Engel J Jr. Analysis of seizure onset on the basis of wideband EEG recordings, Epilepsia, 2005; 46(Suppl 5): 59-63.Bragin Anatol, Wilson Charles L, Fields Tony, Fried Itzhak, Engel Jerome Analysis of seizure onset on the basis of wideband EEG recordings Epilepsia, 2005; 46 Suppl 5(1): 59-63.Engel Jerome Classification is not EZ Epileptic disorders : international epilepsy journal with videotape, 2005; 7(4): 317-20.Engel J Jr. Classification is not EZ, Epileptic Disord, 2005; 7(4): 317-20.Engel Jerome Epilepsy and seizure disorder Epilepsia, 2005; 46(8): 1333; author reply 1334.Engel J Jr. Epilepsy and seizure disorder, Epilepsia, 2005; 46(8): 1333.Griggs JJ, Engel J Jr. Epilepsy surgery and the racial divide, Neurology, 2005; 64(1): 8-9.Griggs Jennifer J, Engel Jerome Epilepsy surgery and the racial divide Neurology, 2005; 64(1): 8-9.Fisher RS, van Emde Boas W, Blume W, Elger C, Genton P, Lee P, Engel J Jr. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE), Epilepsia, 2005; 46(4): 470-2.Fisher Robert S, van Emde Boas Walter, Blume Warren, Elger Christian, Genton Pierre, Lee Phillip, Engel Jerome Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) Epilepsia, 2005; 46(4): 470-2.Bookheimer S, Schrader LM, Rausch R, Sankar R, Engel J Jr. Reduced anesthetization during the intracarotid amobarbital (Wada) test in patients taking carbonic anhydrase-inhibiting medications, Epilepsia, 2005; 46(2): 236-43.Bookheimer Susan, Schrader Lara M, Rausch Rebecca, Sankar Raman, Engel Jerome Reduced anesthetization during the intracarotid amobarbital (Wada) test in patients taking carbonic anhydrase-inhibiting medications Epilepsia, 2005; 46(2): 236-43.Lin JJ, Salamon N, Dutton RA, Lee AD, Geaga JA, Hayashi KM, Toga AW, Engel J Jr, Thompson PM. Three-dimensional preoperative maps of hippocampal atrophy predict surgical outcomes in temporal lobe epilepsy, Neurology, 2005; 65(7): 1094-7.Bragin Anatol, Wilson Charles L, Almajano Joyel, Mody Istvan, Engel Jerome High-frequency oscillations after status epilepticus: epileptogenesis and seizure genesis Epilepsia, 2004; 45(9): 1017-23.Bragin A, Wilson CL, Almajano J, Mody I, Engel J Jr. High-frequency oscillations after status epilepticus: epileptogenesis and seizure genesis, Epilepsia, 2004; 45(9): 1017-23.Staba Richard J, Wilson Charles L, Bragin Anatol, Jhung Donald, Fried Itzhak, Engel Jerome High-frequency oscillations recorded in human medial temporal lobe during sleep Annals of neurology, 2004; 56(1): 108-15.Staba RJ, Wilson CL, Bragin A, Jhung D, Fried I, Engel J Jr. High-frequency oscillations recorded in human medial temporal lobe during sleep, Ann Neurol, 2004; 56(1): 108-15.Bragin A, Karsten SL, Almajano J, Wilson CL, Geschwind DH, Engel J Jr. Large-scale microarray gene expression analysis in discrete electrophysiologically identified neuronal clusters, J Neurosci Methods, 2004; 133(1-2): 49-55.Bragin, A Karsten, SL Almajano, J Wilson, CL Geschwind, DH Engel, J Large-scale microarray gene expression analysis in discrete electrophysiologically identified neuronal clusters Journal of neuroscience methods. , 2004; 133(1-2): 49-55.Bragin Anatol, Karsten Stanislav L, Almajano Joyel, Wilson Charles L, Geschwind Daniel H, Engel Jerome Large-scale microarray gene expression analysis in discrete electrophysiologically identified neuronal clusters Journal of neuroscience methods, 2004; 133(1-2): 49-55.Engel J Jr. Models of focal epilepsy, Suppl Clin Neurophysiol, 2004; 57: 392-9.Engel Jerome Models of focal epilepsy Supplements to Clinical neurophysiology, 2004; 57(2): 392-9.Schrader Lara M, Stern John M, Koski Lisa, Nuwer Marc R, Engel Jerome Seizure incidence during single- and paired-pulse transcranial magnetic stimulation (TMS) in individuals with epilepsy Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2004; 115(12): 2728-37.Schrader LM, Stern JM, Koski L, Nuwer MR, Engel J Jr. Seizure incidence during single- and paired-pulse transcranial magnetic stimulation (TMS) in individuals with epilepsy, Clin Neurophysiol, 2004; 115(12): 2728-37.Engel J Jr. The goal of epilepsy theraphy: no seizures, no side effects, as soon as possible, CNS Spectr, 2004; 9(2): 95-7.Engel Jerome The goal of epilepsy therapy: no seizures, no side effects, as soon as possible CNS spectrums, 2004; 9(2): 95-7.Mintzer Scott, Cendes Fernando, Soss Jason, Andermann Frederick, Engel Jerome, Dubeau Francois, Olivier Andre, Fried Itzhak Unilateral hippocampal sclerosis with contralateral temporal scalp ictal onset Epilepsia, 2004; 45(7): 792-802.Mintzer S, Cendes F, Soss J, Andermann F, Engel J JR, Dubeau F, Olivier A, Fried I. Unilateral hippocampal sclerosis with contralateral temporal scalp ictal onset, Epilepsia, 2004; 45(7): 792-802.Engel J Jr. A Greater Role for Surgical Treatment of Epilepsy: Why and When?, Epilepsy Curr, 2003; 3(2): 37-40.Engel Jerome A Greater Role for Surgical Treatment of Epilepsy: Why and When? Epilepsy currents / American Epilepsy Society, 2003; 3(2): 37-40.Engel J Jr, Wilson C, Bragin A. Advances in understanding the process of epileptogenesis based on patient material: what can the patient tell us?, Epilepsia, 2003; 44(Suppl 12): 60-71.Engel Jerome, Wilson Charles, Bragin Anatol Advances in understanding the process of epileptogenesis based on patient material: what can the patient tell us? Epilepsia, 2003; 44 Suppl 12(1): 60-71.Engel J Jr. Bringing epilepsy out of the shadows, Neurology, 2003; 60(9): 1412.Engel Jerome Bringing epilepsy out of the shadows Neurology, 2003; 60(9): 1412.Swarztrauber K, Dewar S, Engel J Jr. Patient attitudes about treatments for intractable epilepsy, Epilepsy Behav, 2003; 4(1): 19-25.Swarztrauber Kari, Dewar Sandra, Engel Jerome Patient attitudes about treatments for intractable epilepsy Epilepsy & behavior : E&B, 2003; 4(1): 19-25.Swarztrauber, K Dewar, S Engel, J Patient attitudes about treatments for intractable epilepsy Epilepsy & behavior : E&B. , 2003; 4(1): 19-25.Engel J Jr, Wiebe S, French J, Sperling M, Williamson P, Spencer D, Gumnit R, Zahn C, Westbrook E, Enos B; Quality Standards Subcommittee of the American Academy of Neurology; American Epilepsy Society; American Association of Neurological Surgeons. Practice parameter: temporal lobe and localized neocortical resections for epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology, in association with the American Epilepsy Society and the American Association of Neurological Surgeons, Neurology, 2003; 60(4): 538-47.Engel Jerome, Wiebe Samuel, French Jacqueline, Sperling Michael, Williamson Peter, Spencer Dennis, Gumnit Robert, Zahn Catherine, Westbrook Edward, Enos Bruce Practice parameter: temporal lobe and localized neocortical resections for epilepsy Epilepsia, 2003; 44(6): 741-51.Engel, J Wiebe, S French, J Sperling, M Williamson, P Spencer, D Gumnit, R Zahn, C Westbrook, E Enos, B Practice parameter: temporal lobe and localized neocortical resections for epilepsy Epilepsia. , 2003; 44(6): 741-51.Engel J Jr, Wiebe S, French J, Sperling M, Williamson P, Spencer D, Gumnit R, Zahn C, Westbrook E, Enos B. Practice parameter: temporal lope and localized neocortical resections for epilepsy, Epilepsia, 2003; 44(6): 741-51.Engel J Jr. Early versus late surgery for intractable seizures, Adv Exp Med Biol, 2002; 497: 99-105.Engel Jerome Early versus late surgery for intractable seizures Advances in experimental medicine and biology, 2002; 497(5): 99-105.Eliashiv DS, Elsas SM, Squires K, Fried I, Engel J Jr. Ictal magnetic source imaging as a localizing tool in partial epilepsy, Neurology, 2002; 59(10): 1600-10.Bragin A, Wilson CL, Engel J Jr. Increased afterdischarge threshold during kindling in epileptic rats, Exp Brain Res, 2002; 144(1): 30-7.Bragin Anatol, Wilson Charles L, Engel Jerome Increased afterdischarge threshold during kindling in epileptic rats Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale, 2002; 144(1): 30-7.Bragin Anatol, Wilson Charles L, Staba Richard J, Reddick Mark, Fried Itzhak, Engel Jerome Interictal high-frequency oscillations (80-500 Hz) in the human epileptic brain: entorhinal cortex Annals of neurology, 2002; 52(4): 407-15.Bragin, A Wilson, CL Staba, RJ Reddick, M Fried, I Engel, J Interictal high-frequency oscillations (80-500 Hz) in the human epileptic brain: entorhinal cortex Annals of neurology. , 2002; 52(4): 407-15.Bragin A, Wilson CL, Staba RJ, Reddick M, Fried I, Engel J Jr. Interictal high-frequency oscillations (80-500 Hz) in the human epileptic brain: entorhinal cortez, Ann Neurol, 2002; 52(4): 407-15.Bragin A, Mody I, Wilson CL, Engel J Jr. Local generation of fast ripples in epileptic brain, J Neurosci, 2002; 22(5): 2010-21.Bragin, A Mody, I Wilson, CL Engel, J Local generation of fast ripples in epileptic brain The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2002; 22(5): 2012-21.Bragin Anatol, Mody Istvan, Wilson Charles L, Engel Jerome Local generation of fast ripples in epileptic brain The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002; 22(5): 2012-21.Staba Richard J, Wilson Charles L, Bragin Anatol, Fried Itzhak, Engel Jerome Quantitative analysis of high-frequency oscillations (80-500 Hz) recorded in human epileptic hippocampus and entorhinal cortex Journal of neurophysiology, 2002; 88(4): 1743-52.Staba RJ, Wilson CL, Bragin A, Fried I, Engel J Jr. Quantitative analysis of high-frequency oscillations (80-500 Hz) recorded in human epileptic hippocampus and entorhinal cortex, J Neurophysiol, 2002; 88(4): 1743-52.Bragin A, Wilson CL, Engel J Jr. Rate of interictal events and spontaneous seizures in epileptic rats after electrical stimulation of hippocampus and its afferents, Epilepsia, 2002; 43(Suppl 5): 81-5.Bragin Anatol, Wilson Charles L, Engel Jerome Rate of interictal events and spontaneous seizures in epileptic rats after electrical stimulation of hippocampus and its afferents Epilepsia, 2002; 43 Suppl 5(5): 81-5.Goldman, RI Stern, JM Engel, J Cohen, MS Simultaneous EEG and fMRI of the alpha rhythm Neuroreport. , 2002; 13(18): 2487-92.Goldman Robin I, Stern John M, Engel Jerome, Cohen Mark S Simultaneous EEG and fMRI of the alpha rhythm Neuroreport, 2002; 13(18): 2487-92.Goldman RI, Stern JM, Engel J Jr, Cohen MS. Simultaneous EEG and fMRI of the alpha rhythm, Neuroreport, 2002; 13(18): 2487-92.Staba RJ, Wilson CL, Fried I, Engel J Jr. Single neuron burst firing in the human hippocampus during sleep, Hippocampus, 2002; 12(6): 724-34.Staba Richard J, Wilson Charles L, Fried Itzhak, Engel Jerome Single neuron burst firing in the human hippocampus during sleep Hippocampus, 2002; 12(6): 724-34.Staba Richard J, Wilson Charles L, Bragin Anatol, Fried Itzhak, Engel Jerome Sleep states differentiate single neuron activity recorded from human epileptic hippocampus, entorhinal cortex, and subiculum The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002; 22(13): 5694-704.Staba RJ, Wilson CL, Bragin A, Fried I, Engel J Jr. Sleep states differentiate single neuron activity recorded from human epileptic hippocampus, entorhinal cortex, adn subiculum, J Neurosci, 2002; 22(13): 5694-704.Engel J Jr. So what can we conclude–do seizures damage the brain?, Prog Brain Res, 2002; 135: 509-12.Engel Jerome So what can we conclude–do seizures damage the brain? Progress in brain research, 2002; 135(6): 509-12.Zeitzer, JM Maidment, NT Behnke, EJ Ackerson, LC Fried, I Engel, J Wilson, CL Ultradian sleep-cycle variation of serotonin in the human lateral ventricle Neurology. , 2002; 59(8): 1272-4.Zeitzer JM, Maidment NT, Behnke EJ, Ackerson LC, Fried I, Engel J Jr, Wilson CL. Ultradian sleep-cycle variation of serotonin in the human lateral ventricle, Neurology, 2002; 59(8): 1272-4.Engel J Jr; International League Against Epilepsy (ILAE) A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology, Epilepsia, 2001; 42(6): 796-803.Engel J Jr. Classification of epileptic disorders, Epilepsia, 2001; 42(3): 316.Engel J Jr. Finally, a randomized, controlled trial of epilepsy surgery, N Engl J Med, 2001; 345(5): 365-7.Blume WT, Luders HO, Mizrahi E, Tassinari C, van Emde Boas W, Engel J Jr. Glossary of descriptive terminology for ictal semiology: report of the ILAE task force on classification and terminology, Epilepsia, 2001; 42(9): 1212-8.Engel J Jr. Intractable epilepsy: definitioin and neurobiology, Epilepsia, 2001; 42(Suppl 6): 3.Engel J Jr. Mesial temporal lobe epilepsy: what have we learned?, Neuroscientist, 2001; 7(4): 340-52.Goldman, RI Stern, JM Engel, J Cohen, MS Acquiring simultaneous EEG and functional MRI Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. , 2000; 111(11): 1974-80.Bragin, A Wilson, CL Engel, J Chronic epileptogenesis requires development of a network of pathologically interconnected neuron clusters: a hypothesis Epilepsia. , 2000; 41 Suppl 6: S144-52.Savic, I Thomas, AM Ke, Y Curran, J Fried, I Engel, J In vivo measurements of glutamine + glutamate (Glx) and N-acetyl aspartate (NAA) levels in human partial epilepsy Acta neurologica Scandinavica. , 2000; 102(3): 179-88.Bragin A, Hetke J, Wilson CL, Anderson DJ, Engel J Jr, Buzsaki G Multiple site silicon-based probes for chronic recordings in freely moving rats: implantation, recording and histological verification, J Neurosci Methods, 2000; 98(1): 77-82.Fried, I Wilson, CL Maidment, NT Engel, J Behnke, E Fields, TA MacDonald, KA Morrow, JW Ackerson, L Cerebral microdialysis combined with single-neuron and electroencephalographic recording in neurosurgical patients. Technical note Journal of neurosurgery. , 1999; 91(4): 697-705.Bragin, A Engel, J Wilson, CL Vizentin, E Mathern, GW Electrophysiologic analysis of a chronic seizure model after unilateral hippocampal KA injection Epilepsia. , 1999; 40(9): 1210-21.Bragin A, Engel J Jr, Wilson CL, Fried I, Buzsaki G High-frequency oscillations in human brain, Hippocampus, 1999; 9(2): 137-42.Bragin, A Engel, J Wilson, CL Fried, I Mathern, GW Hippocampal and entorhinal cortex high-frequency oscillations (100–500 Hz) in human epileptic brain and in kainic acid–treated rats with chronic seizures Epilepsia. , 1999; 40(2): 127-37.Lopez-Rodriguez, F Altshuler, L Kay, J Delarhim, S Mendez, M Engel, J Personality disorders among medically refractory epileptic patients The Journal of neuropsychiatry and clinical neurosciences. , 1999; 11(4): 464-9.Engel, J. Jr. and Pedley, T. A. (Eds) Epilepsy: A comprehensive Textbook, Philadelphia, Lippencott Raven Press, 1998; Vol. 1, 2 & 3: pp 2,976.Wilson, CL Khan, SU Engel, J Isokawa, M Babb, TL Behnke, EJ Paired pulse suppression and facilitation in human epileptogenic hippocampal formation Epilepsy research. , 1998; 31(3): 211-30.Isokawa, M Levesque, M Fried, I Engel, J Glutamate currents in morphologically identified human dentate granule cells in temporal lobe epilepsy Journal of neurophysiology. , 1997; 77(6): 3355-69.Eliashiv, SD Dewar, S Wainwright, I Engel, J Fried, I Long-term follow-up after temporal lobe resection for lesions associated with chronic seizures Neurology. , 1997; 48(5): 1383-8.Savic I, Bookheimer SY, Fried I, Engel J Jr Olfactory bedside test. A simple approach to identify temporo-orbitofrontal dysfunction, Arch Neurol, 1997; 54(2): 162-8.Savic, I Altshuler, L Baxter, L Engel, J Pattern of interictal hypometabolism in PET scans with fludeoxyglucose F 18 reflects prior seizure types in patients with mesial temporal lobe seizures Archives of neurology. , 1997; 54(2): 129-36.Engel, J. Jr. Current concepts: Surgery for seizures, N. Engl. J. Med, 1996; 334: 647-652.Engel, J. Jr. Excitation and inhibition in epilepsy, Can. J. Neurol. Sci, 1996; 23: 167-174.
Rocha, L Maidment, NT Evans, CJ Ackermann, RF Engel, J Opioid peptide release and mu-receptor binding during amygdala kindling in rats: regional discordances Epilepsy research. Supplement. , 1996; 12: 215-28.
