James Bisley, Ph.D.

Biography
Dr Bisley received his Ph.D. from the University of Melbourne in Australia where he studied the peripheral somatosensory system. He did his first post-doc at the University of Rochester working with Dr Tatiana Pasternak, where he studied the neural mechanisms underlying memory for motion. In 1999, he went to Washington, DC where he worked with Dr Michael E. Goldberg at Georgetown University and the National Eye Institute, studying the neural mechanisms underlying visuo-spatial attention. Dr Bisley moved to Columbia University with Dr Goldberg in 2002 and joined UCLA in 2006.

Publications
Arcizet F., Mirpour K., Foster D.J., Charpentier C.J., Bisley J.W. LIP activity in the inter-stimulus interval of a change detection task biases the behavioral response Journal of Neurophysiology, 2015; jn.00604.2015.
Mirpour K., Bisley J.W. Remapping, Spatial Stability, and Temporal Continuity: From the Pre-Saccadic to Postsaccadic Representation of Visual Space in LIP Cerebral Cortex, 2015; 15(12): .
Zelinsky G.J., Bisley J.W. The what, where, and why of priority maps and their interactions with visual working memory Annals of the New York Academy of Sciences, 2015; 1339(12): 154-64.
Krishna B.S., Ipata A.E., Bisley J.W., Gottlieb J., Goldberg M.E. Extrafoveal preview benefit during free-viewing visual search in the monkey Journal of Vision, 2014; 14(1): .
Mirpour K., Bisley J.W. Evidence for differential top-down and bottom-up suppression in posterior parietal cortex Philosophical Transactions of the Royal Society of London B, 2013; 368(1628): 20130069.
Wottawa C.R., Cohen J.R., Fan R.E., Bisley J.W., Culjat M.O., Grundfest W.S., Dutson E.P. The role of tactile feedback in grip force during laparoscopic training tasks Surgical Endoscopy, 2013; 27(4): 1111-8.
Shariat Torbaghan S., Yazdi D., Mirpour K., Bisley J.W. Inhibition of return in a visual foraging task in non-human subjects Vision Research, 2012; 74(4): 2-9.
Mirpour K., Bisley J.W. Anticipatory remapping of attentional priority across the entire visual field The Journal of Neuroscience, 2012; 32(46): 16449-57.
Mirpour K., Bisley J.W. Dissociating activity in the lateral intraparietal area from value using a visual foraging task Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(25): 10083-8.
Arcizet F., Mirpour K., Bisley J.W. A pure salience response in posterior parietal cortex Cerebral Cortex, 2011; 21(11): 2498-506.
Ong W.S., Bisley J.W. A lack of anticipatory remapping of retinotopic receptive fields in the middle temporal area J Neurosci, 2011; 31(29): 10432-6.
Bisley J.W., Mirpour K., Arcizet F., Ong W.S. The role of the lateral intraparietal area in orienting attention and its implications for visual search Euro J Neurosci, 2011; 33(11): 1982-90.
Bisley J.W. The neural basis of visual attention J Physiol, 2011; 589(Pt 1): 49-57.
Bisley J.W., Goldberg M.E. Attention, intention, and priority in the parietal lobe Ann Rev Neurosci, 2010; 33(6): 1-21.
Mirpour K., Ong W.S., Bisley J.W. Microstimulation of posterior parietal cortex biases the selection of eye movement goals during search J Neurophysiol, 2010; 104(6): 3021-8.
Culjat M.O., Bisley J.W., King C.-H., Wottawa C., Fan R.E., Dutson E.P., Grundfest W.S. Tactile feedback in surgical robotics, Surgical Robotics – Systems, Applications and Visions, 2010; 449-468.
Mirpour K., Arcizet F., Ong W.S., Bisley J.W. Been there, seen that: a neural mechanism for performing efficient visual search J Neurophysiol, 2009; 102(6): 3481-91.
Ong W.S., Hooshvar N., Zhang M., Bisley J.W. Psychophysical evidence for spatiotopic processing in area MT in a short-term memory for motion task J Neurophysiol, 2009; 102(4): 2435-40.
King C.-H., Culjat M.O., Franco M., Lewis C.E., Dutson E.P., Grundfest W.S., Bisley J.W. Tactile feedback induces reduced grasping force in robot-assisted surgery, IEEE Trans Haptics , 2009; 2: 103-110.
Bisley J.W., Ipata A.E., Krishna B.S., Gee A.L., Goldberg M.E. The lateral intraparietal area: a priority map in posterior parietal cortex, Cortical Mechanisms of Vision, 2009; 9-34.
Ipata A.E., Gee A.L., Bisley J.W., Goldberg M.E. Neurons in the lateral intraparietal area create a priority map by the combination of disparate signals Exp Brain Res, 2009; 192(3): 479-88.
King C.-H., Culjat M.O., Franco M.L., Bisley J.W., Dutson E., Grundfest W.S. Optimization of a pneumatic balloon tactile display for robot-assisted surgery based on human perception IEEE Trans Biomed Eng, 2008; 55(11): 2593-600.
Gee A.L., Ipata A.E., Gottlieb J., Bisley J.W., Goldberg M.E. Neural enhancement and pre-emptive perception: the genesis of attention and the attentional maintenance of the cortical salience map Perception, 2008; 37(3): 389-400.
Fan R.E., Culjat M.O., King C.-H., Franco M.L., Boryk R., Bisley J.W., Dutson E., Grundfest W.S. A haptic feedback system for lower-limb prostheses IEEE Trans Neural Syst Rehabil Eng, 2008; 16(3): 270-7.
Ganguli S., Bisley J.W., Roitman J.D., Shadlen M.N., Goldberg M.E., Miller K.D. One-dimensional dynamics of attention and decision making in LIP Neuron, 2008; 58(1): 15-25.
Gee A.L., Ipata A.E., Bisley J.W., Gottlieb J., Goldberg M.E. On the agnosticism of spikes: salience, saccades, and attention in the lateral intraparietal area of the monkey, Sensorimotor Foundations of Higher Cognition: Attention and Performance XXII, 2007; 3-25.
Ipata A.E., Gee A.L., Goldberg M.E., Bisley J.W. Activity in the lateral intraparietal area predicts the goal and latency of saccades in a free viewing visual search task J. Neurosci, 2006; 26(14): 3656-3661.
Ipata A.E., Gee A.L., Gottlieb J., Bisley J.W., Goldberg M.E. LIP responses to a popout stimulus are reduced if it is overtly ignored Nat Neurosci, 2006; 9(8): 1071-1076.
Bisley J.W., Goldberg M.E. Neural correlates of attention and distractibility in the lateral intraparietal area J Neurophysiol, 2006; 95(3): 1696-717.
Goldberg M.E., Bisley J.W., Powell K.D., Gottlieb J. Saccades, salience and attention: the role of the lateral intraparietal area in visual behavior Prog Brain Res, 2006; 155: 157-175.
Bisley J.W., Zaksas D., Droll J.A., Pasternak T. Activity of neurons in cortical area MT during a memory for motion task J Neurophysiol, 2004; 91(1): 286-300.
Bisley J.W., Krishna B.S., Goldberg M.E. A rapid and precise on-response in posterior parietal cortex J Neurosci, 2004; 24(8): 1833-8.
Bisley J.W., Goldberg M.E. The role of the parietal cortex in the neural processing of saccadic eye movements Adv Neurol, 2003; 93: 141-57.
Pasternak T., Bisley J.W., Calkins D. Visual information processing in the primate brain, Biological Psychology, 2003; 139-185.
Bisley J.W., Goldberg M.E. Neuronal activity in the lateral intraparietal area and spatial attention Science, 2003; 299(5603): 81-6.
Bisley J.W., Zaksas D., Pasternak T. Microstimulation of cortical area MT affects performance on a visual working memory task J Neurophysiol, 2001; 85(1): 187-96.
Zaksas D., Bisley J.W., Pasternak T. Motion information is spatially localized in a visual working-memory task J Neurophysiol, 2001; 86(2): 912-21.
Bisley J.W., Goodwin A.W., Wheat H.E. Slowly adapting type I afferents from the sides and end of the finger respond to stimuli on the center of the fingerpad J Neurophysiol, 2000; 84(1): 57-64.
Bisley J.W., Pasternak T. The multiple roles of visual cortical areas MT/MST in remembering the direction of visual motion Cereb Cortex, 2000; 10(11): 1053-65.
Goodwin A.W., Macefield V.G., Bisley J.W. Encoding of object curvature by tactile afferents from human fingers J Neurophysiol, 1997; 78(6): 2881-8.
Bisley J.W., Rees S.M., McKinley M.J., Hards D.K., Oldfield B.J. Identification of osmoresponsive neurons in the forebrain of the rat: a Fos study at the ultrastructural level Brain Res, 1996; 720(1-2): 25-34.

Felix Schweizer Ph.D.

Academic Titles/Accomplishments/Affiliations:

Director, Neurosciences Interdepartmental Program
Vice-Chair for Education, Department of Neurobiology
Member, Neuroscience GPB Home Area
Collaborator, Vestibular Neuroscience Laboratory
Member, Brain Research Institute
Cell & Developmental Biology GPB Home Area
Molecular, Cellular & Integrative Physiology GPB Home Area

Felix E. Schweizer was born in Basel, Switzerland and conducted his graduate research in the laboratory of Prof. Max M. Burger under the direction of Dr. Theo Schafer. He received his PhD degree in biochemistry summa cum laude from the University of Basel in 1989. From 1990 to 1994, he was a post-doctoral fellow in the Department of Molecular and Cellular Physiology at Stanford University in the laboratory of Prof. Richard W. Tsien. From 1994 to 1998, he was postdoctoral fellow in the Department of Neurobiology at Duke University in the laboratory of Professor George J. Augustine. Dr. Schweizer joined the Department of Neurobiology in the David Geffen School of Medicine at UCLA in 1998 as Assistant Professor and was promoted to Full Professor in 2010. Dr. Schweizer’s research interests concern the molecular mechanisms by which neurons communicate, the regulation of communication by neurons and how alterations in neuronal communication might contribute to neuronal diseases. The Schweizer laboratory uses electrophysiological and optical tools to investigate the dynamic molecular mechanisms underlying the regulation of neurotransmitter release. We are particularly interested in the role of protein ubiquitination in regulating neuronal excitability and synaptic transmission. In collaboration with Dr. James Wohlschlegel, we used multiplexed SILAC and identified synaptic proteins that are dynamically regulated. We are now in the process to test the role of individual proteins in cultured neurons, brain slices and, in collaboration with Dr. David Krantz, in Drosophila. In addition, we are characterizing transmission at the first synapse of the vestibular system, i.e. between utricular sensory hair cells and primary afferent neurons. In collaboration with Dr. Larry Hoffman we are finding that changing the gravitational load alters synaptic structures. We are now using serial EM and EM tomography in addition to physiology and cell biology to define in more detail the transfer function between head-movement input and afferent nerve-firing output.

Paul E Micevych Ph.D.

Research interest:
The research of the laboratory is focused on steroid hormone interactions with the central nervous system. Throughout life, sex steroid hormones profoundly influence the structure and function of specific circuits that regulate reproduction and reproductive behaviors. Previous work had focused on the regulation of neuropeptide and transmitter expression. However, relatively little is known about the mechanisms by which steroids affect postsynaptic activation and signal transduction. The laboratory has three major interests: STEROID MODULATION OF mu-OPIOID RECEPTOR (MOR) ACTIVATION Estrogen treatment of ovariectomized rats initially has an inhibitory action on circuits mediating sexual receptivity (lordosis), but eventually induces sexual receptivity. We have determined that an important component of this inhibition is due to the activation of MOR circuits in the medial preoptic area. Taking advantage of G protein-coupled receptor (GPCR) internalization following activation of the receptor by an endogenous ligand, we determined that activation of MOR is correlated with an inhibition of lordosis. Behaviorally, progesterone augments estrogen action. We have determined that progesterone relieves MOR-mediated inhibition, through the termination of opioid release in the medial preoptic area. Is the MOR-inhibition dependent on estrogen receptors? Working with Dr. Emilie Rissman, (University of Virginia), we have determined that estrogen activation of MOR circuits is dependent on the expression of the estrogen receptor-a (ERa). Although MOR and opioid expression appears nominal in ERa knockout (ERaKO) mice, and MOR-selective opioids internalize MOR, estrogen does not induce internalization. These results and the rapid time course of internalization suggest that the ERa is acting through a nongenomic mechanism. REGULATION OF NEUROSTEROID BIOSYNTHESIS Although it is well known that the brain can synthesize neurosteroids, it has been difficult to determine the function of these steroids in the regulation of reproduction. We have recently determined that peripheral estrogen stimulates the synthesis of progesterone in the hypothalamus. This increased in progesterone is restricted to the hypothalamus and is necessary for the initiation of the LH surge. Examination of cells in vitro suggest that astrocytes are responsible for the estrogen-induced progesterone synthesis. This response to estrogen may be an important component of estrogen positive feedback regulates the LH surge. Males and aging females that do not exhibit positive feedback, that are lacking the ability to increase progesterone synthesis in the hypothalamus. NONGENOMIC ACTIONS OF ESTROGEN MODULATION To begin examining the nongenomic actions of estrogen on regulation of postsynaptic mechanisms, we have studied the response of Ca2+ in dorsal root ganglion (DRG) cells. DRG cells provide an accessible and practical solution to quantitatively study the chemosensitive properties of estrogen-sensitive neurons. These cells express ERa and a number of other well characterized Ca2+ channels. We have been studying the effects of estrogen on modulation of P2X receptors (ATP receptors) and activity of voltage dependent Ca2+ channels (VdCC) using digital videomicroscopy for [Ca2+]i changes. Recent results indicate that 17-beta estradiol inhibited ATP-mediated [Ca2+]i responses and attenuated Ca2+ rise by acting on L-type VDCC in both male and female DRG neurons

The reproductive hormones estradiol and progesterone bathe our internal organs. They have profound influence over the central and peripheral nervous system. While these steroids have been studied for many years, recent advances indicate that many actions of estradiol in the nervous system are mediated by receptors located on the cell membrane, suggesting more of a neurotransmitter than a hormonal role. My lab is working to understand the multiple mechanisms and circuits through which estrogen and progesterone affect cell types in different systems to affect reproduction, behavior, pain transmission and neuroprotection.