Alcino Silva, PhD

About

Alcino Silva was born in Portugal in 1961, but his family moved to Luanda, Angola, when he was 3 years old. He came to the United States to attend Rutgers University in 1979. There, he worked with William Sofer on Drosophila tRNA non-sense suppressors and minored in philosophy (epistemology). In 1983 he joined the graduate program of human genetics at the University of Utah, where he worked with Ray White, a pioneer in Human Genetics, and showed for the first time the inheritance of epigenetic information. While a graduate student, Dr. Silva organized yearly graduate symposia where leading luminaries from the Arts and Sciences shared their insights on the nature of innovation and creativity. During his post-doctoral work at the Massachusetts Institute of Technology with Nobel Laureate Dr. Susumu Tonegawa (1988-92), Dr. Alcino J. Silva introduced transgenic mice to neuroscience studies of learning and memory and pioneered the field of Molecular and Cellular Cognition. This work was critical in demonstrating a role for synaptic plasticity in learning and memory. His first independent position (1992) was with the Cold Spring Harbor Laboratory, NY, where his research group had a key role in the development of Molecular and Cellular Cognition into a mainstream neuroscience field. In 2002 Dr. Silva founded and became the first President of the Molecular and Cellular Cognition Society, an international organization with more than 8000 members and with branches in North America, Asia and Europe. Studies in his laboratory have uncovered fundamental mechanisms of learning and memory, memory allocation, memory linking and mechanisms of memory disorders, work which led to multiple clinical trials testing mechanisms of cognitive disorders, including those associated with Neurofibromatosis type I, and Tuberous sclerosis. Additionally, Dr. Silva has led a group of scientists in the Adelson Foundation that leveraged mechanisms of brain plasticity to uncover new approaches to accelerate recovery after brain injury. These efforts led to ongoing clinical trials to test their impact on recovery after stroke. Besides work on molecular and cellular cognition, his laboratory also works on developing approaches for systematic studies of scientific practices. The goal is to develop pragmatic, validated, general principles for increasing the efficiency of science, including leveraging AI approaches in summarizing the literature and planning new experiments. He is currently a Distinguished Professor of Neurobiology, Psychiatry & Biobehavioral Sciences, and Psychology and heads the Integrative Center for Learning and memory at UCLA. He has been awarded a number of prizes and distinctions, including most recently the Order of Prince Henry, the highest award given by the Portuguese Government to a Private citizen, the Marco Canavezes Medal of Science, and the Senior Roche Award For Translational Neuroscience, he is a Fellow, American Association for the Advancement Science, a Ewha Global Fellow, etc.

Publications

1. White, R., M. Leppert, P. O'Connell, Y. Nakamura, C. Julier, S. Woodward, A. Silva, R. Wolff, M. Lathrop, and J.M. Lalouel, Construction of human genetic linkage maps: I. Progress and perspectives. Cold Spring Harb Symp Quant Biol, 1986. 51 Pt 1: p. 29-38. PMID: 3472726.

2. White, R., Y. Nakamura, C. Julier, A.J. Silva, P. O'Connell, M. Leppert, M. Lathrop, and J.-M. Lalouel, DNA Probes: Applications in Genetic and Infectious Disease and Cancer, in Current Communications in Molecular Biology, e. L.S.Lerman, Editor. 1986: Cold Spring Harbor. p. 43-47.

3. Silva, A.J., J.P. Johnson, and R.L. White, Characterization of a highly polymorphic region 5' to JH in the human immunoglobulin heavy chain. Nucleic Acids Res, 1987. 15(9): p. 3845-57. PMCID: PMC340786.

4. Nakamura, Y., C. Martin, A. Silva, M. Leppert, P. O'Connell, G.M. Lathrop, J.M. Lalouel, and R. White, Isolation and mapping of a polymorphic DNA sequence (pCMI37) on chromosome 7 [D7S368]. Nucleic Acids Res, 1988. 16(9): p. 4192.

5. Silva, A.J. and R. White, Inheritance of allelic blueprints for methylation patterns. Cell, 1988. 54(2): p. 145-52. PMID: 2898978.

6. Silva, A.J. and R. White, Thesis for a Ph.D. in the Department of Human Genetics, University of Utah: The genetics of human methylation. UMI, Bell and Howell Information Company, #3058. 1989.

7. Silva, A.J., K. Ward, and R. White, The genetics of mosaic methylation patterns. UCLA Symposia, Nucleic Acid Methylation. Vol. 128. 1990. 395-408.

8. Silva, A.J., R. Paylor, J.M. Wehner, and S. Tonegawa, Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science, 1992. 257(5067): p. 206-11. PMID: 1321493.

9. Silva, A.J., C.F. Stevens, S. Tonegawa, and Y. Wang, Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science, 1992. 257(5067): p. 201-6. PMID: 1378648.

10. Silva, A.J., Y. Wang, R. Paylor, J.M. Wehner, C.F. Stevens, and S. Tonegawa, Alpha calcium/calmodulin kinase II mutant mice: deficient long-term potentiation and impaired spatial learning. Cold Spring Harb Symp Quant Biol, 1992. 57: p. 527-39. PMID: 1339689.

11. Abeliovich, A., C. Chen, Y. Goda, A.J. Silva, C.F. Stevens, and S. Tonegawa, Modified hippocampal long-term potentiation in PKC gamma-mutant mice. Cell, 1993. 75(7): p. 1253-62. PMID: 8269509.

12. Silva, A.J., R. Paylor, J.M. Wehner, and S. Tonegawa, Responses. Science, 1993. 262(5134): p. 761-762.

13. Silva, A.J., K. Ward, and R. White, Mosaic methylation in clonal tissue. Dev Biol, 1993. 156(2): p. 391-8. PMID: 8462739.

14. Bourtchuladze, R., B. Frenguelli, J. Blendy, D. Cioffi, G. Schutz, and A.J. Silva, Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell, 1994. 79(1): p. 59-68. PMID: 7923378.

15. Grant, S.G. and A.J. Silva, Targeting learning. Trends Neurosci, 1994. 17(2): p. 71-5.

16. Silva, A.J. and P.F. Chapman, The alpha-calcium calmodulin kinase II and the plasticity of neurons, circuits and behavior. The Neurosciences, 1994. 6: p. 53-58.

17. Silva, A.J. and K.P. Giese, Plastic genes are in! Curr Opin Neurobiol, 1994. 4(3): p. 413-20.

18. Butler, L.S., A.J. Silva, A. Abeliovich, Y. Watanabe, S. Tonegawa, and J.O. McNamara, Limbic epilepsy in transgenic mice carrying a Ca2+/calmodulin-dependent kinase II alpha-subunit mutation. Proc Natl Acad Sci U S A, 1995. 92(15): p. 6852-5. PMCID: PMC41427.

19. Chapman, P.F., B.G. Frenguelli, A. Smith, C.M. Chen, and A.J. Silva, The alpha-Ca2+/calmodulin kinase II: a bidirectional modulator of presynaptic plasticity. Neuron, 1995. 14(3): p. 591-7. PMID: 7695905.

20. Tonegawa, S., Y. Li, R.S. Erzurumlu, S. Jhaveri, C. Chen, Y. Goda, R. Paylor, A.J. Silva, J.J. Kim, J.M. Wehner, and et al., The gene knockout technology for the analysis of learning and memory, and neural development. Prog Brain Res, 1995. 105: p. 3-14. PMID: 7568891.

21. Tonegawa, S., Y. Li, R.S. Erzurumlu, S. Jhaveri, C. Chen, Y. Goda, R. Paylor, A.J. Silva, J.J. Kim, J.M. Wehner, C.F. Stevens, and A. Abeliovich, The gene knockout technology for the analysis of learning and memory, and neural development. 1995. p. 3-14. PMID: 7568891.

22. Fox, K., S. Glazewski, C.M. Chen, A. Silva, and X. Li, Mechanisms underlying experience-dependent potentiation and depression of vibrissae responses in barrel cortex. J Physiol Paris, 1996. 90(3-4): p. 263-9. PMID: 9116680.

23. Glazewski, S., C.M. Chen, A. Silva, and K. Fox, Requirement for alpha-CaMKII in experience-dependent plasticity of the barrel cortex. Science, 1996. 272(5260): p. 421-3. PMID: 8602534.

24. Gordon, J.A., D. Cioffi, A.J. Silva, and M.P. Stryker, Deficient plasticity in the primary visual cortex of alpha-calcium/calmodulin-dependent protein kinase II mutant mice. Neuron, 1996. 17(3): p. 491-9. PMID: 8816712.

25. Silva, A.J., Genetics and learning: misconceptions and criticisms, in Gene targeting and new developments in neurobiology, S. Nakanishi , et al., Editors. 1996, Japan Scientific Societies Press: Tokyo.

26. Silva, A.J., N. Fedorov, J. Kogan, P. Frankland, J. Coblentz, R. Lundsten, E. Friedman, A. Smith, Y. Cho, and K.P. Giese, Genetic analysis of function and dysfunction in the central nervous system. Cold Spring Harb Symp Quant Biol, 1996. 61: p. 239-46. PMID: 9246452.

27. Silva, A.J., T.W. Rosahl, P.F. Chapman, Z. Marowitz, E. Friedman, P.W. Frankland, V. Cestari, D. Cioffi, T.C. Sudhof, and R. Bourtchuladze, Impaired learning in mice with abnormal short-lived plasticity. Curr Biol, 1996. 6(11): p. 1509-18. PMID: 8939606.

28. Waxham, M.N., J.C. Grotta, A.J. Silva, R. Strong, and J. Aronowski, Ischemia-induced neuronal damage: a role for calcium/calmodulin-dependent protein kinase II. J Cereb Blood Flow Metab, 1996. 16(1): p. 1-6. PMID: 8530541.

29. Wehner, J. M., & Silva, A. (1996). Importance of strain differences in evaluations of learning and memory processes in null mutants. Mental Retardation and Developmental Disabilities Research Reviews, 2, 243–248. PMID: No number available.

30. Crawley, J.N., J.K. Belknap, A. Collins, J.C. Crabbe, W. Frankel, N. Henderson, R.J. Hitzemann, S.C. Maxson, L.L. Miner, A.J. Silva, J.M. Wehner, A. Wynshaw-Boris, and R. Paylor, Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology (Berl), 1997. 132(2): p. 107-24. PMID: 9266608.

31. Kirkwood, A., A. Silva, and M.F. Bear, Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice. Proc Natl Acad Sci U S A, 1997. 94(7): p. 3380-3. PMCID: PMC20378.

32. Kogan, J.H., P.W. Frankland, J.A. Blendy, J. Coblentz, Z. Marowitz, G. Schutz, and A.J. Silva, Spaced training induces normal long-term memory in CREB mutant mice. Curr Biol, 1997. 7(1): p. 1-11. PMID: 8999994.

33. Pongs, O., K.P. Giese, J.F. Storm, D. Reuter, N.B. Fedorov, L.-R. Shao, T. Leicher, and A.J. Silva, Abnormal neuronal firing and impaired learning in Kvbeta1.1-deficient mice. 1997. p. 119-120.

34. Silva, A. and et al, Mutant mice and neuroscience: recommendations concerning genetic background. Banbury Conference on genetic background in mice [see comments]. Neuron, 1997. 19(4): p. 755-9.

35. Silva, A.J., P.W. Frankland, Z. Marowitz, E. Friedman, G.S. Laszlo, D. Cioffi, T. Jacks, and R. Bourtchuladze, A mouse model for the learning and memory deficits associated with neurofibromatosis type I. Nat Genet, 1997. 15(3): p. 281-4. PMID: 9054942.

36. Silva, A.J., S. Kida, J. Blendy, J. Coblentz, Z. Marowitz, C. Yoon, G. Schutz, and J. Kogan, The involvement of CREB in mammalian memory. Journal of Neurochemistry, 1997. 69(SUPPL.): p. S254.

37. Silva, A.J., A.M. Smith, and K.P. Giese, Gene targeting and the biology of learning and memory. Annu Rev Genet, 1997. 31: p. 527-46. PMID: 9442906.

38. Cho, Y.H., K.P. Giese, H. Tanila, A.J. Silva, and H. Eichenbaum, Abnormal hippocampal spatial representations in alphaCaMKIIT286A and CREBalphaDelta- mice. Science, 1998. 279(5352): p. 867-9. PMID: 9452387.

39. Frankland, P.W., V. Cestari, R.K. Filipkowski, R.J. McDonald, and A.J. Silva, The dorsal hippocampus is essential for context discrimination but not for contextual conditioning. Behav Neurosci, 1998. 112(4): p. 863-74. PMID: 9733192.

40. Giese, K.P., N.B. Fedorov, R.K. Filipkowski, and A.J. Silva, Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science, 1998. 279(5352): p. 870-3. PMID: 9452388.

41. Giese, K.P., J.F. Storm, D. Reuter, N.B. Fedorov, L.R. Shao, T. Leicher, O. Pongs, and A.J. Silva, Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning. Learn Mem, 1998. 5(4-5): p. 257-73. PMCID: PMC311244.

42. Silva, A.J., Y. Elgersma, E. Friedman, J. Stern, and J. Kogan, A mouse model for learning and memory defects associated with neurofibromatosis type I. Pathol Biol (Paris), 1998. 46(9): p. 697-8. PMID: 9885821.

43. Silva, A.J., P.W. Frankland, J.H. Kogan, E. Friedman, and N.B. Fedorov, A model for the cognitive impairments associated with NF1, in Neurofibromatosis type I (NF1): From genotype to phenotype, M. Upadhyaya and C. DN, Editors. 1998, BIOS Scientific of Oxford: Oxford.

44. Silva, A.J. and K.P. Giese, Gene targeting: a novel window into the biology of learning and memory, in Neurobiology of learning and memory, J. Martinez and R. Kesner, Editors. 1998, Academic Press: San Diego, CA. p. 89-142.

45. Silva, A.J., K.P. Giese, N.B. Fedorov, P.W. Frankland, and J.H. Kogan, Molecular, cellular, and neuroanatomical substrates of place learning. Neurobiol Learn Mem, 1998. 70(1-2): p. 44-61. PMID: 9753586.

46. Silva, A.J., P.K. Giese, and P.W. Frankland, Identification of molecular and cellular mechanisms of learning and memory: the role of gene targeting, in The Aging Brain, E. Wang and D.S. Snyder, Editors. 1998, Academic Press: San Diego, CA. p. 68-82.

47. Silva, A.J., J.H. Kogan, P.W. Frankland, and S. Kida, CREB and memory. Annu Rev Neurosci, 1998. 21: p. 127-48.

48. Cho, Y.H., E. Friedman, and A.J. Silva, Ibotenate lesions of the hippocampus impair spatial learning but not contextual fear conditioning in mice. Behav Brain Res, 1999. 98(1): p. 77-87. PMID: 10210524.

49. Elgersma, Y. and A.J. Silva, Molecular mechanisms of synaptic plasticity and memory. Curr Opin Neurobiol, 1999. 9(2): p. 209-13. PMID: 10322188.

50. Glazewski, S., A.L. Barth, H. Wallace, M. McKenna, A. Silva, and K. Fox, Impaired experience-dependent plasticity in barrel cortex of mice lacking the alpha and delta isoforms of CREB. Cereb Cortex, 1999. 9(3): p. 249-56. PMID: 10355905.

51. Narisawa-Saito, M., A.J. Silva, T. Yamaguchi, T. Hayashi, T. Yamamoto, and H. Nawa, Growth factor-mediated Fyn signaling regulates alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression in rodent neocortical neurons. Proc Natl Acad Sci U S A, 1999. 96(5): p. 2461-6. PMCID: PMC26807.

52. Pongs, O., T. Leicher, M. Berger, J. Roeper, R. Bahring, D. Wray, K.P. Giese, A.J. Silva, and J.F. Storm, Functional and molecular aspects of voltage-gated K+ channel beta subunits. Ann N Y Acad Sci, 1999. 868: p. 344-55. PMID: 10414304.

53. Silva, A.J., N. Fedorov, E. Friedman, J. Stern, R. Costa, and J. Kogan, Curing the learning deficits associated with NF1 in mice. Journal of Neurochemistry, 1999. 72(SUPPL): p. S6.

54. Silva, A.J. and G.G. Murphy, cAMP and memory: a seminal lesson from Drosophila and Aplysia. Brain Res Bull, 1999. 50(5-6): p. 441-2. PMID: 10643474.

55. Anagnostaras, S.G., S.A. Josselyn, P.W. Frankland, and A.J. Silva, Computer-assisted behavioral assessment of Pavlovian fear conditioning in mice. Learn Mem, 2000. 7(1): p. 58-72. PMCID: PMC311321.

56. Falls, W.A., J.H. Kogan, A.J. Silva, J.F. Willott, S. Carlson, and J.G. Turner, Fear-potentiated startle, but not prepulse inhibition of startle, is impaired in CREBalphadelta-/- mutant mice. Behav Neurosci, 2000. 114(5): p. 998-1004. PMID: 11085615.

57. Ferguson, G.D., S.G. Anagnostaras, A.J. Silva, and H.R. Herschman, Deficits in memory and motor performance in synaptotagmin IV mutant mice. Proc Natl Acad Sci U S A, 2000. 97(10): p. 5598-603. PMCID: PMC25874.

58. Frankland, P.W., A. Kirkwood, and A.J. Silva, A role for alpha-CaMKII in late phases of memory consolidation. European Journal of Neuroscience, 2000. 12(Supplement 11): p. 253.

59. Glazewski, S., K.P. Giese, A. Silva, and K. Fox, The role of alpha-CaMKII autophosphorylation in neocortical experience-dependent plasticity. Nat Neurosci, 2000. 3(9): p. 911-8. PMID: 10966622.

60. Kogan, J.H., P.W. Frankland, and A.J. Silva, Long-term memory underlying hippocampus-dependent social recognition in mice. Hippocampus, 2000. 10(1): p. 47-56. PMID: 10706216.

61. Pandey, S.C., N. Mittal, and A.J. Silva, Blockade of cyclic AMP-responsive element DNA binding in the brain of CREB delta/alpha mutant mice. Neuroreport, 2000. 11(11): p. 2577-80. PMID: 10943725.

62. Silva, A.J., Y. Elgersma, and R.M. Costa, Molecular and cellular mechanisms of cognitive function: implications for psychiatric disorders. Biol Psychiatry, 2000. 47(3): p. 200-9. PMID: 10682217.

63. Carvalho, O., A. Silva, and B. Balleine, Evidence of Selective Learning Deficits on Tests of Pavlovian and Instrumental Conditioning in alpha-CaMKIIT286A Mutant Mice. International Journal of Comparative Psychology, 2001. 14: p. 161-174.

64. Costa, R.M., T. Yang, D.P. Huynh, S.M. Pulst, D.H. Viskochil, A.J. Silva, and C.I. Brannan, Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1. Nat Genet, 2001. 27(4): p. 399-405. PMID: 11279521.

65. Frankland, P.W., C. O'Brien, M. Ohno, A. Kirkwood, and A.J. Silva, Alpha-CaMKII-dependent plasticity in the cortex is required for permanent memory. Nature, 2001. 411(6835): p. 309-13. PMID: 11357133.

66. Giese, K.P., E. Friedman, J.-B. Telliez, N.B. Fedorov, M. Wines, L.A. Feig, and A.J. Silva, Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1). Neuropharmacology, 2001. 41(6): p. 791-800. PMID: 11640934.

67. Hamilton, S.E., S.N. Hardouin, S.G. Anagnostaras, G.G. Murphy, K.N. Richmond, A.J. Silva, E.O. Feigl, and N.M. Nathanson, Alteration of cardiovascular and neuronal function in M1 knockout mice. Life Sci, 2001. 68(22-23): p. 2489-93. PMID: 11392617.

68. Josselyn, S.A., S. Kida, S. Pena, and A.J. Silva, CREB. memory and plasticity, in The Handbook of Chemical Neuroanatomy, T.B. Hokfelt, A., Editor. 2001, Elsevier: Amsterdam.

69. Matynia, A., S.G. Anagnostaras, and A.J. Silva, Weaving the molecular and cognitive strands of memory. Neuron, 2001. 32(4): p. 557-9. PMID: 11719197.

70. Ohno, M., P.W. Frankland, A.P. Chen, R.M. Costa, and A.J. Silva, Inducible, pharmacogenetic approaches to the study of learning and memory. Nat Neurosci, 2001. 4(12): p. 1238-43. PMID: 11713472.

71. Pham, T.A., J.L. Rubenstein, A.J. Silva, D.R. Storm, and M.P. Stryker, The CRE/CREB pathway is transiently expressed in thalamic circuit development and contributes to refinement of retinogeniculate axons. Neuron, 2001. 31(3): p. 409-20. PMID: 11516398.

72. Silva, A., Memory: genetic approaches, in E-L, N.J.S.a.P.B.B. . Editor. 2001, Pergamon, Oxford. p. 9583-9586.

73. Silva, A.J., Genetic approaches to memory, in Corcini encyclopedia of psychology and behavioral sciences, W. Craighead and C. Nemeroff, Editors. 2001, John Wiley & Sons: New York. p. 626-9.

74. Silva, A.J., Y. Elgersma, and R. Costa, From genes to therapies: the role of animal models. Clinical Neuroscience Research, 2001. 1: p. 187-193.

75. Costa, R.M., Y. Elgersma, and A.J. Silva, Modeling cognitive disorders: from genes to therapies, in Neurobehavioral Disorders, G. Fisch, Editor. 2002, Humana Press.

76. Costa, R.M., N.B. Federov, J.H. Kogan, G.G. Murphy, J. Stern, M. Ohno, R. Kucherlapati, T. Jacks, and A.J. Silva, Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature, 2002. 415(6871): p. 526-30. PMID: 11793011.

77. Costa, R.M. and A.J. Silva, Molecular and cellular mechanisms underlying the cognitive deficits associated with neurofibromatosis 1. J Child Neurol, 2002. 17(8): p. 622-6; discussion 627-9, 646-51. PMID: 12403561.

78. Elgersma, Y., N.B. Fedorov, S. Ikonen, E.S. Choi, M. Elgersma, O.M. Carvalho, K.P. Giese, and A.J. Silva, Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron, 2002. 36(3): p. 493-505. PMID: 12408851.

79. Givogri, M.I., R.M. Costa, V. Schonmann, A.J. Silva, A.T. Campagnoni, and E.R. Bongarzone, Central nervous system myelination in mice with deficient expression of Notch1 receptor. Journal of Neuroscience Research, 2002. 67(3): p. 309-320. PMID: 11813235.

80. Josselyn, S., S. Kida, P. Sandra, and A. Silva, CREB, plasticity and memory, in “Immediate Early genes and inducible transcription factors in mapping of the central nervous system function and dysfunction”, L. Kaczmarek and H. Robertson, Editors. 2002, Elsevier Science. p. 329-361.

81. Kida, S., S.A. Josselyn, S.P. de Ortiz, J.H. Kogan, I. Chevere, S. Masushige, and A.J. Silva, CREB required for the stability of new and reactivated fear memories. Nat Neurosci, 2002. 5(4): p. 348-55. PMID: 11889468.

82. Matynia, A., S.A. Kushner, and A.J. Silva, Genetic approaches to molecular and cellular cognition: a focus on LTP and learning and memory. Annu Rev Genet, 2002. 36: p. 687-720. PMID: 12429705.

83. Ohno, M., P.W. Frankland, and A.J. Silva, A pharmacogenetic inducible approach to the study of NMDA/alphaCaMKII signaling in synaptic plasticity. Curr Biol, 2002. 12(8): p. 654-6. PMID: 11967152.

84. Silva, A.J., Genetic Approaches to Memory, in Concise Corsini Encyclopedia of Psychology and Behavioral Sciences. 2002, Pergamon: Oxford.

85. Silva, A.J. and S.A. Josselyn, The molecules of forgetfulness. Nature, 2002. 418(6901): p. 929-30. PMID: 12198533.

86. Taha, S., J.L. Hanover, A.J. Silva, and M.P. Stryker, Autophosphorylation of alphaCaMKII is required for ocular dominance plasticity. Neuron, 2002. 36(3): p. 483-91. PMID: 12408850.

87. Anagnostaras, S.G., G.G. Murphy, S.E. Hamilton, S.L. Mitchell, N.P. Rahnama, N.M. Nathanson, and A.J. Silva, Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice. Nat Neurosci, 2003. 6(1): p. 51-8. PMID: 12483218.

88. Bozon, B., A. Kelly, S.A. Josselyn, A.J. Silva, S. Davis, and S. Laroche, MAPK, CREB and zif268 are all required for the consolidation of recognition memory. Philos Trans R Soc Lond B Biol Sci, 2003. 358(1432): p. 805-14. PMCID: PMC1693143.

89. Costa, R.M., T. Honjo, and A.J. Silva, Learning and memory deficits in Notch mutant mice. Curr Biol, 2003. 13(15): p. 1348-54. PMID: 12906797.

90. Costa, R.M. and A.J. Silva, Mouse models of neurofibromatosis type I: bridging the GAP. Trends Mol Med, 2003. 9(1): p. 19-23. PMID: 12524206.

91. Dhaka, A., R.M. Costa, H. Hu, D.K. Irvin, A. Patel, H.I. Kornblum, A.J. Silva, T.J. O'Dell, and J. Colicelli, The RAS effector RIN1 modulates the formation of aversive memories. J Neurosci, 2003. 23(3): p. 748-57. PMID: 12574403.

92. Frankland, P.W., M. Ohno, E. Takahashi, A.R. Chen, R.M. Costa, S.A. Kushner, and A.J. Silva, Pharmacologically regulated induction of silent mutations (PRISM): combined pharmacological and genetic approaches for learning and memory. Neuroscientist, 2003. 9(2): p. 104-9. PMID: 12708614.

93. Silva, A., Genetic Substrates of Memory: Hippocampus, in Learning and Memory, 2nd Edition, J.H. Byrne, Editor. 2003, Macmillan Reference USA: New York. p. 171-175.

94. Silva, A., Memory Consolidation: Molecular and Cellular Processes, in Learning and Memory, 2nd Edition, J.H. Byrne, Editor. 2003, Macmillan Reference USA: New York. p. 366-369.

95. Silva, A.J., Molecular and cellular cognitive studies of the role of synaptic plasticity in memory. J Neurobiol, 2003. 54(1): p. 224-37. PMID: 12486706.

96. Wang, J., K. Ren, J. Perez, A.J. Silva, and S. Pena de Ortiz, The antimetabolite ara-CTP blocks long-term memory of conditioned taste aversion. Learn Mem, 2003. 10(6): p. 503-9. PMCID: PMC305465.

97. Weeber, E.J., Y.H. Jiang, Y. Elgersma, A.W. Varga, Y. Carrasquillo, S.E. Brown, J.M. Christian, B. Mirnikjoo, A. Silva, A.L. Beaudet, and J.D. Sweatt, Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome. J Neurosci, 2003. 23(7): p. 2634-44. PMID: 12684449.

98. Brown, R. and A.J. Silva, Molecular and cellular cognition; the unraveling of memory retrieval. Cell, 2004. 117(1): p. 3-4. PMID: 15066276.

99. Frankland, P.W., B. Bontempi, L.E. Talton, L. Kaczmarek, and A.J. Silva, The involvement of the anterior cingulate cortex in remote contextual fear memory. Science, 2004. 304(5672): p. 881-3. PMID: 15131309.

100. Frankland, P.W., S.A. Josselyn, S.G. Anagnostaras, J.H. Kogan, E. Takahashi, and A.J. Silva, Consolidation of CS and US representations in associative fear conditioning. Hippocampus, 2004. 14(5): p. 557-69. PMID: 15301434.

101. Frankland, P.W., Y. Wang, B. Rosner, T. Shimizu, B.W. Balleine, E.M. Dykens, E.M. Ornitz, and A.J. Silva, Sensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice. Mol Psychiatry, 2004. 9(4): p. 417-25. PMID: 14981523.

102. Israely, I., R.M. Costa, C.W. Xie, A.J. Silva, K.S. Kosik, and X. Liu, Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction. Curr Biol, 2004. 14(18): p. 1657-63. PMID: 15380068.

103. Josselyn, S.A., S. Kida, and A.J. Silva, Inducible repression of CREB function disrupts amygdala-dependent memory. Neurobiol Learn Mem, 2004. 82(2): p. 159-63. PMID: 15341801.

104. Murphy, G.G., N.B. Fedorov, K.P. Giese, M. Ohno, E. Friedman, R. Chen, and A.J. Silva, Increased neuronal excitability, synaptic plasticity, and learning in aged Kvbeta1.1 knockout mice. Curr Biol, 2004. 14(21): p. 1907-15. PMID: 1550391.

105. Suzuki, A., S.A. Josselyn, P.W. Frankland, S. Masushige, A.J. Silva, and S. Kida, Memory reconsolidation and extinction have distinct temporal and biochemical signatures. J Neurosci, 2004. 24(20): p. 4787-95. PMID: 15152039.

106. Wiltgen, B.J., R.A. Brown, L.E. Talton, and A.J. Silva, New circuits for old memories: the role of the neocortex in consolidation. Neuron, 2004. 44(1): p. 101-8. PMID: 15450163.

107. Zeitz, K.P., K.P. Giese, A.J. Silva, and A.I. Basbaum, The contribution of autophosphorylated alpha-calcium-calmodulin kinase II to injury-induced persistent pain. Neuroscience, 2004. 128(4): p. 889-98. PMID: 15464294.

108. Costa, R.M., C. Drew, and A.J. Silva, Notch to remember. Trends Neurosci, 2005. 28(8): p. 429-35. PMID: 15922461.

109. Ehninger, D., A. Matynia, and A.J. Silva, Trafficking in emotions. Nat Neurosci, 2005. 8(5): p. 548-50.

110. Kushner, S.A., Y. Elgersma, G.G. Murphy, D. Jaarsma, G.M. van Woerden, M.R. Hojjati, Y. Cui, J.C. LeBoutillier, D.F. Marrone, E.S. Choi, C.I. De Zeeuw, T.L. Petit, L. Pozzo-Miller, and A.J. Silva, Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway. J Neurosci, 2005. 25(42): p. 9721-34. PMCID: PMC2802213.

111. Li, W., Y. Cui, S.A. Kushner, R.A. Brown, J.D. Jentsch, P.W. Frankland, T.D. Cannon, and A.J. Silva, The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr Biol, 2005. 15(21): p. 1961-7. PMID: 16271875.

112. Ohno, M., W. Tseng, A.J. Silva, and J.F. Disterhoft, Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of alphaCaMKII in mice. Learn Mem, 2005. 12(3): p. 211-5. PMID: 15897256.

113. Acosta, M.T., G.A. Gioia, and A.J. Silva, Neurofibromatosis type 1: new insights into neurocognitive issues. Curr Neurol Neurosci Rep, 2006. 6(2): p. 136-43. PMID: 16522267.

114. Chen, A.P., M. Ohno, K.P. Giese, R. Kuhn, R.L. Chen, and A.J. Silva, Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory. J Neurosci Res, 2006. 83(1): p. 28-38. PMID: 16342120.

115. Frankland, P.W., H.K. Ding, E. Takahashi, A. Suzuki, S. Kida, and A.J. Silva, Stability of recent and remote contextual fear memory. Learn Mem, 2006. 13(4): p. 451-7. PMCID: PMC1538922.

116. Murphy, G.G., N.P. Rahnama, and A.J. Silva, Investigation of age-related cognitive decline using mice as a model system: behavioral correlates. Am J Geriatr Psychiatry, 2006. 14(12): p. 1004-11. PMID: 17138807.

117. Murphy, G.G., V. Shah, J.W. Hell, and A.J. Silva, Investigation of age-related cognitive decline using mice as a model system: neurophysiological correlates. Am J Geriatr Psychiatry, 2006. 14(12): p. 1012-21. PMID: 17138808.

118. Nagy, V., O. Bozdagi, A. Matynia, M. Balcerzyk, P. Okulski, J. Dzwonek, R.M. Costa, A.J. Silva, L. Kaczmarek, and G.W. Huntley, Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory. J Neurosci, 2006. 26(7): p. 1923-34. PMID: 16481424.

119. Ohno, M., E.A. Sametsky, A.J. Silva, and J.F. Disterhoft, Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability. Eur J Neurosci, 2006. 23(8): p. 2235-40. PMID: 16630070.

120. Uchida, S., S. Sakai, T. Furuichi, H. Hosoda, K. Toyota, T. Ishii, A. Kitamoto, M. Sekine, K. Koike, S. Masushige, G. Murphy, A.J. Silva, and S. Kida, Tight regulation of transgene expression by tetracycline-dependent activator and repressor in brain. Genes Brain Behav, 2006. 5(1): p. 96-106. PMID: 16436193.

121. Wiltgen, B., R. Brown, L. Talton, and A. Silva, Towards a molecular and cellular cognition of remote memory. 2006, Springer.

122. Bontempi, B., A. Silva, and Y. Christen, Memories: Molecules and Circuits. Research and Perspectives in Neurosciences, ed. Y. Christen. 2007, Paris.

123. Han, J.H., S.A. Kushner, A.P. Yiu, C.J. Cole, A. Matynia, R.A. Brown, R.L. Neve, J.F. Guzowski, A.J. Silva, and S.A. Josselyn, Neuronal competition and selection during memory formation. Science, 2007. 316(5823): p. 457-60. PMID: 17446403.

124. Hojjati, M.R., G.M. van Woerden, W.J. Tyler, K.P. Giese, A.J. Silva, L. Pozzo-Miller, and Y. Elgersma, Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses. Nat Neurosci, 2007. 10(9): p. 1125-7. PMCID: 2804046.

125. Ishizuka, K., J. Chen, S. Taya, W. Li, J.K. Millar, Y. Xu, S.J. Clapcote, C. Hookway, M. Morita, A. Kamiya, T. Tomoda, B.K. Lipska, J.C. Roder, M. Pletnikov, D. Porteous, A.J. Silva, T.D. Cannon, K. Kaibuchi, N.J. Brandon, D.R. Weinberger, and A. Sawa, Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice. Mol Psychiatry, 2007. 12(10): p. 897-9. PMID: 17895924.

126. Li, W., Y. Zhou, J.D. Jentsch, R.A. Brown, X. Tian, D. Ehninger, W. Hennah, L. Peltonen, J. Lonnqvist, M.O. Huttunen, J. Kaprio, J.T. Trachtenberg, A.J. Silva, and T.D. Cannon, Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci U S A, 2007. 104(46): p. 18280-5. PMCID: 2084334.

127. Wiltgen, B.J. and A.J. Silva, Memory for context becomes less specific with time. Learn Mem, 2007. 14(4): p. 313-7. PMID: 17522020.

128. Won, J. and A.J. Silva, Molecular and cellular mechanisms of memory allocation in neuronetworks. Neurobiol Learn Mem, 2007. PMCID: PMC2673809.

129. Zhou, Y., E. Takahashi, W. Li, A. Halt, B. Wiltgen, D. Ehninger, G.D. Li, J.W. Hell, M.B. Kennedy, and A.J. Silva, Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning. J Neurosci, 2007. 27(50): p. 13843-53. PMID: 18077696.

130. Silva, A.J., The science of research: the principles underlying the discovery of cognitive and other biological mechanisms. J Physiol Paris, 2007. 101(4-6): p. 203-13. PMID: 18280120

131. Silva, A., Consolidation: molecular restlessness, in Science of Memory: Concepts, H. Roediger, Y. Dudai, and S. Fitzpatrick, Editors. 2007, Oxford University Press.

132. Matynia, A., S.G. Anagnostaras, B.J. Wiltgen, M. Lacuesta, M.S. Fanselow, and A.J. Silva, A high through-put reverse genetic screen identifies two genes involved in remote memory in mice. PLoS ONE, 2008. 3(5): p. e2121. PMCID: PMC2373872.

133. Ehninger, D., S. Han, C. Shilyansky, Y. Zhou, W. Li, D.J. Kwiatkowski, V. Ramesh, and A.J. Silva, Reversal of learning deficits in a Tsc2(+/-) mouse model of tuberous sclerosis. Nat Med, 2008; 14, 843–848. PMCID: PMC2664098.

134. Krab, L.C., A. de Goede-Bolder, F.K. Aarsen, S.M. Pluijm, M.J. Bouman, J.N. van der Geest, M. Lequin, C.E. Catsman, W.F. Arts, S.A. Kushner, A.J. Silva, C.I. de Zeeuw, H.A. Moll, and Y. Elgersma, Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trial. Jama, 2008. 300(3): p. 287-94. PMCID: PMC2664742.

135. Wayman, G.A., Y.S. Lee, H. Tokumitsu, A. Silva, and T.R. Soderling, Calmodulin-kinases: modulators of neuronal development and plasticity. Neuron, 2008. 59(6): p. 914-31. PMCID: PMC2664743.

136. Shilyansky C et al. Molecular and Cellular Mechanisms of learning disabilities: a focus on neurofibromatosis type I. Animal and Translational Models of Behavioral Disorders, vol 2 – Neurologic Disorders, RA McArthur and F Borsini (Eds), Elsevier, 77-93, Oct 1 2008

137. Cui, Y, Costa, RM, Murphy, GG, Elgersma, Y, Zhu, Y, Gutmann, DH, Parada, LF, Mody, I, and Silva, AJ, Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell 2008 135(3) pp. 549 – 560. PMCID: PMC2673196.

138. C. Shilyansky, B. J. Wiltgen, and A. J. Silva. Neurofibromatosis Type I Learning Disabilities. In J. David Sweatt (Ed.), Molecular Mechanisms of Memory. Vol. [4] of Learning and Memory: A Comprehensive Reference, 4 vols. (J.Byrne Editor), pp. [387-408] Oxford: Elsevier.

139. Ehninger, D., Li, W, Fox, K, Stryker, MP, and Silva, AJ. Reversing neurodevelopmental disorders in adults. Neuron 2008;60(6):950-60. PMCID: PMC2710296.

140. Bickle, J. and Silva, A. (2008). Intimology and the Search for the Molecular Mechanisms of Cognitive Functions. Bickle, J. (Eds.), Oxford Handbook of Philosophy and Neuroscience. Oxford: Oxford University Press.

141. Lee, Y-S and Silva, AJ. The molecular and cellular biology of enhanced cognition Nat Rev Neurosci. 2009 Feb;10(2):126-40. PMID: 19153576

142. Huynh, D.P., Maalouf, M., Silva, A.J., Schweizer, F.E., and Pulst, S.M. Dissociated fear and spatial learning in mice with deficiency of ataxin-2. PLoS One 2009; 4, e6235. PMCID: PMC2707006.

143. Ehninger, D. and A.J. Silva, Genetics and neuropsychiatric disorders: treatment during adulthood. Nat Med, 2009. 15(8): p. 849-50. 54. PMID: 19661989.

144. Zhou, Y, Won J., Karlsson, M.G. Zhou, M., Rogerson, T, Balaji, J., Neve, R., Poirazi, P., Silva, A.J. CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala. Nature Neuroscience, 2009. 12(11): p. 1438-43 Sep 27. PMCID: PMC2783698.

145. Ehninger, D. and Silva, A.J. From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis. Journal of Intellectual Disability Research, 2009. 53(10): 838-51. PMID: 19694899.

146. Silva, A.J., Zhou, Y, Rogerson, T, Shobe, J and Balaji, J. Molecular and Cellular Approaches to Memory Allocation in Neural Circuits. Science, Oct 16 2009;326(5951):391-5. PMID: 19833959.

147. Hutnick LK, Golshani P, Namihira M, Xue Z, Matynia A, Yang XW, Silva AJ, Schweizer FE, Fan G. DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation. Hum Mol Genet. 2009 Aug 1;18(15):2875-88. PMCID: PMC2706688.

148. Silva AJ, Ehninger D. Adult reversal of cognitive phenotypes in neurodevelopmental disorders. J Neurodev Disord. 2009 Jun;1(2):150-157. PMCID: PMC2755132.

149. Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T. Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. Am J Med Genet A. 2010 Jan;152A(1):4-24.PMID: 20014119

150. Lee Y-S and Silva A J (2010) Knock-Outs: Learning and Memory. In: Koob G.F., Le Moal M. and Thompson R.F. (eds.) Encyclopedia of Behavioral Neuroscience, volume 2, pp. 123–130 Oxford: Academic Press.

151. Shilyansky, C., Lee,Y.-S., Silva, A.J. Molecular and cellular mechanisms of learning disabilities: a focus on NF1. Annu Rev Neurosci. 2010;33:221-43 PMID: 20345245

152. Buard, I., S.J. Coultrap, R.K. Freund, Y.S. Lee, M.L. Dell'Acqua, A.J. Silva, and K.U. Bayer, CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage. J Neurosci, 2010. 30(24): p. 8214-20. PMID: 20554872

153. Shilyansky C, Karlsgodt KH, Cummings DM, Sidiropoulou K, Hardt M, James AS, Ehninger D, Bearden CE, Poirazi P, Jentsch JD, Cannon TD, Levine MS, Silva AJ. Neurofibromin regulates corticostriatal inhibitory networks during working memory performance. Proc Natl Acad Sci U S A. 2010 Jul 12. PMID: 20624961

154. Kaneko M, Cheetham CE, Lee Y-S, Silva AJ, Stryker MP, Fox K. Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(44):19026-31. PubMed PMID: Medline:20937865.

155. Wiltgen, B.J., M. Zhou, Y. Cai, J. Balaji, M.G. Karlsson, S.N. Parivash, W. Li, and A.J. Silva, The Hippocampus Plays a Selective Role in the Retrieval of Detailed Contextual Memories. Curr Biol, 2010. 20(15): p. 1336-1344. PMID: 20637623

156. Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ, Fan G. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci. 2010 Apr;13(4):423-30. PMID: 20228804.

157. Ehninger, D. and A.J. Silva, Increased Levels of Anxiety-related Behaviors in a Tsc2 Dominant Negative Transgenic Mouse Model of Tuberous Sclerosis. Behav Genet, 2011 May; 41(3): 357–3632010. PMCID: PMC3102774

158. Matynia, A., C.H. Ng, W. Dansithong, A. Chiang, A.J. Silva, and S. Reddy, Muscleblind1, but not Dmpk or Six5, contributes to a complex phenotype of muscular and motivational deficits in mouse models of myotonic dystrophy. PLoS One, 2010. 5(3): p. e9857.PMCID 2845609

159. Zhao, Y., C. Fung, D. Shin, B.C. Shin, S. Thamotharan, R. Sankar, D. Ehninger, A. Silva, and S.U. Devaskar, Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders. Molecular psychiatry, 2010. 15(3): p. 286-99.

160. Crego, Cortney; Landreth, Anthony; and Silva, Alcino J (April 2011)

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161. Silva, A.J., A career that transformed neuroscience. Brain research bulletin, 2011.

162. Kye, M.J., P. Neveu, Y.S. Lee, M. Zhou, J.A. Steen, M. Sahin, K.S. Kosik, and A.J. Silva, NMDA mediated contextual conditioning changes miRNA expression. PloS one, 2011. 6(9): p. e24682.

163. Ehninger, D. and A.J. Silva, Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders. Trends in Molecular Medicine, 2011. 17(2): p. 78-87. PMCID: PMC3075964

164. Ehninger, D. and A.J. Silva, Increased levels of anxiety-related behaviors in a Tsc2 dominant negative transgenic mouse model of tuberous sclerosis. Behavior genetics, 2011. 41(3): p. 357-63.

165. Lee, Y.S. and A.J. Silva, Modeling hyperactivity: of mice and men. Nature Medicine, 2011. 17(5): p. 541-2. PMID: 21546967

166. Silva AJ. Molecular genetic approaches to memory consolidation. In: Nalbantian S, Matthews PM, McClelland JL, editors. The Memory Process: Neuroscientific and Humanistic Perspectives. first ed. 55 Hayward St. Cambridge, MA 02142 USA: the MIT Press; 2011. p. 41-55.

167. Ehninger, D., Y. Sano, P.J. de Vries, K. Dies, D. Franz, D.H. Geschwind, M. Kaur, Y.S. Lee, W. Li, J.K. Lowe, J.A. Nakagawa, M. Sahin, K. Smith, V. Whittemore, and A.J. Silva, Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice. Molecular Psychiatry, 2012. 17(1): p. 62-70. PMID: 21079609

168. Halt, A.R., R.F. Dallapiazza, Y. Zhou, I.S. Stein, H. Qian, S. Juntti, S. Wojcik, N. Brose, A.J. Silva, and J.W. Hell, CaMKII binding to GluN2B is critical during memory consolidation. The EMBO journal, 2012. 31(5): p. 1203-16. PMID:22234183

169. Cho, J., R. Bhatt, Y. Elgersma, and A.J. Silva, alpha-Calcium Calmodulin Kinase II Modulates the Temporal Structure of Hippocampal Bursting Patterns. PloS one, 2012. 7(2): p. e31649. PMID: 22363696

170. Gdalyahu, A., Tring, E., Polack, P., Gruver, R., Golshani, P., Fanselow, M. S., Silva, Trachtenberg, J. T. (2012) Associative Fear Learning Enhances Sparse Network Coding in Primary Sensory Cortex. Neuron, 75, 121-132. PMID: 22794266

171. Acosta MT, Bearden CE, Castellanos XF, Cutting L, Elgersma Y, Gioia G, Gutmann DH, Lee YS, Legius E, Muenke M, North K, Parada LF, Ratner N, Hunter-Schaedle K, Silva AJ. (2012). "The Learning Disabilities Network (LeaDNet): Using neurofibromatosis type 1 (NF1) as a paradigm for translational research." American Journal of Medical Genetics. Sep;158A(9):2225-32. PMID: 22821737

172. Karlsgodt K, , Rosser T, Lutkenhoff ES, Cannon TD, Silva AJ, and Bearden CE (2012). Alterations in white matter microstructure in neurofibromatosis-1. PloS one 7(10): e47854. PMID: 23094098

173. Gutmann DH, Parada LF, Silva AJ, Ratner N. Neurofibromatosis type 1: modeling CNS dysfunction. J Neurosci. 2012 Oct 10;32(41):14087-93. J NEUROSCI.3242-12.2012. PMID: 23055477

174. Caccamo A, Magrì A, Medina DX, Wisely EV, López-Aranda MF, Silva AJ, Oddo S. mTor regulates tau phosphorylation and degradation: implications for alzheimer's disease and other tauopathies. Aging Cell. 2013 Feb 20. doi: 10.1111/acel.12057. PMID: 23425014

175. Zhou, M, Li, W, Huang, S, Song, J, Kim, J Tian, X, Kang, E Sano, Y, Liu, C, Balaji, J, Wu, S, Zhou, Y, Zhou, Y, Parivash, S, Ehninger, D, He, L. Song, H, 3, Ming, G, Silva AJ mTOR Inhibition Ameliorates Cognitive and Affective Deficits Caused by Disc1 Knockdown Specifically in Adult-Born Dentate Granule Neurons. Neuron 77, 647–654, 2013 PMID: 23439118

176. Han X, Chen M, Wang F, Windrem M, Wang S, Shanz S, Xu Q, Oberheim NA, Bekar L, Betstadt S, Silva AJ, Takano T, Goldman SA, Nedergaard M. Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell Stem Cell. 2013 Mar 7;12(3):342-53. PMID: 23472873

177. Landreth, A. and Silva, A.J. The Need for Research Maps to Navigate Published Work and Inform Experiment Planning. Neuron 2013 79 411-415 PMID: 23931992

178. Rogerson, T, Cai, D, Frank, A, Sano, Y, Shobe, J, Aranda, ML, Silva, AJ Synaptic Tagging During Memory Allocation. Nature Reviews Neuroscience 15, 157–169 (2014) PMID: 24496410

179. Czajkowski, R, Jayaprakash, B, Wiltgen, B, Rogerson, T, Karlsson, MG, Barth, A, Trachtenberg, J, and Silva, AJ. Encoding and storage of spatial information in the retrosplenial cortex, PNAS Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8661-6 PMID: 24912150

180. Katharina Achterberg, Gabrielle Buitendijk, Martijn Kool, Susanna Goorden, Laura Post, Denise Slump, Alcino Silva, Geeske van Woerden, Steven Kushner, and Ype Elgersma. Temporal and region-specific requirements of αCaMKII in spatial and contextual learning. J Neurosci. 2014 Aug 20;34(34):11180-7; PMID: 25143599

181. Lee, Y-S, Ehninger, D, Zhou, M, Oh, J-Y, Butz, D, Araki, T, Nam, CI, Balaji, J, Sano, Y, Amin, A, Kim, H, Burger, C, Neel, BG, and Silva, AJ. Mechanism and treatment for the learning and memory deficits associated with mouse models of Noonan syndrome, Nature Neuroscience 17, 1736–1743 (2014); PMID: 25383899

182. Sano, Y, Shobe, JL, Zhou, M, Huang, S, Cai, DJ, Roth, BL, Kamata, M, and Silva, AJ. CREB regulates memory allocation in the insular cortex. Curr Biol. 2014 Nov 13;24(23):2833-283 (2014) PMID: 25454591

183. Le Belle, J.E., Sperry, J., Ngo, A., Ghochani, Y., Laks, D.R., Lopez-Aranda, M., Silva, A.J., and Kornblum, H.I. (2014). Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells. Stem Cell Reports 3, 725-734. PMID: 25143599

184. Omrani A, van der Vaart T, Mientjes E, van Woerden GM, Hojjati MR, Li KW, Gutmann DH, Levelt CN, Smit AB, Silva AJ, Kushner SA, Elgersma Y. HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1. Mol Psychiatry. 2015; PMID: 25917366

185. Kastellakis G, Cai DJ, Mednick SC, Silva AJ, Poirazi. Synaptic clustering within dendrites: an emerging theory of memory formation. P.Prog Neurobiol. 2015 Mar;126:19-35. PMID: 25576663

186. Korf B, Ahmadian R, Allanson J, Aoki Y, Bakker A, Wright EB, Denger B, Elgersma Y, Gelb BD, Gripp KW, Kerr B, Kontaridis M, Lazaro C, Linardic C, Lozano R, MacRae CA, Messiaen L, Mulero-Navarro S, Neel B, Plotkin S, Rauen KA, Roberts A, Silva AJ, Sittampalam SG, Zhang C, Schoyer L. The third international meeting on genetic disorders in the RAS/MAPK pathway: Towards a therapeutic approach. Am J Med Genet A. 2015 Aug;167(8):1741-6. PMID: 25900621

187. Silva AJ, Müller KR. The need for novel informatics tools for integrating and planning research in molecular and cellular cognition. Learn Mem. 2015 Aug 18;22(9):494-8. PMID: 26286658

188. Tomson SN, Schreiner MJ, Narayan M, Rosser T, Enrique N, Silva AJ, Allen GI, Bookheimer SY, Bearden CE. Resting state functional MRI reveals abnormal network connectivity in neurofibromatosis 1. Hum Brain Mapp. 2015 Aug 25.PMID: 26304096

189. Cai DJ, Aharoni D, Shuman T, Shobe J, Biane J, Song W, Wei B, Veshkini M, La-Vu M, Lou J, Flores S, Kim I, Sano Y, Zhou M, Baumgaertel K, Lavi A, Kamata M, Tuszynski M, Mayford M, Golshani P, Silva AJ. A shared neural ensemble links distinct contextual memories encoded close in time. Nature 2016 May 23;534(7605):115-8 PMID:27251287

190. Petrella, L.I., Y. Cai, J.V. Sereno, S.I. Goncalves, A.J. Silva, and M. Castelo-Branco, Brain and behaviour phenotyping of a mouse model of neurofibromatosis type-1: an MRI/DTI study on social cognition. Genes Brain Behav, 2016.

191. Bearden, C.E., G.S. Hellemann, T. Rosser, C. Montojo, R. Jonas, N. Enrique, L. Pacheco, S.A. Hussain, J.Y. Wu, J.S. Ho, J.J. McGough, C.A. Sugar, and A.J. Silva, A randomized placebo-controlled lovastatin trial for neurobehavioral function in neurofibromatosis I. Ann Clin Transl Neurol, 2016. 3(4): p. 266-79.

192. Miou Zhou Stuart Greenhill Shan Huang Tawnie K Silva Yoshitake Sano Shumin Wu Ying Cai Yoshiko Nagaoka Megha Sehgal Denise J Cai Yong-Seok Lee Kevin Fox Alcino J Silva. CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory. DOI: http://dx.doi.org/10.7554/eLife.20985; Published December 20, 2016; Cite as eLife 2016;10.7554/eLife.20985. PMID: 27996938; PMCID: PMC5213777

193. Kastellakis, G., A. J. Silva and P. Poirazi (2016). "Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites." Cell Rep 17(6): 1491-1504. PMID: 27806290

194. Rogerson, T., B. Jayaprakash, D. J. Cai, Y. Sano, Y. S. Lee, Y. Zhou, P. Bekal, K. Deisseroth and A. J. Silva (2016). "Molecular and Cellular Mechanisms for Trapping and Activating Emotional Memories." PLoS One 11(8): e0161655. PMID: 27579481

195. Petrella LI, Cai Y, Sereno JV, Gonçalves SI, Silva AJ, Castelo-Branco M. Brain and behaviour phenotyping of a mouse model of neurofibromatosis type-1: an MRI/DTI study on social cognition. Genes Brain Behav. 2016 Sep;15(7):637-46. doi: 10.1111/gbb.12305. Epub 2016 Jul 5. PMID: 27283753

196. Izquierdo, A., and Silva, A.J. (2016). Hijacking translation in addiction. eLife 5. Elife. 2016 Mar 1;5. pii: e14576. doi: 10.7554/eLife.14576. PMID 26929992

197. Payne, J. M., B. Barton, N. J. Ullrich, A. Cantor, S. J. Hearps, G. Cutter, T. Rosser, K. S. Walsh, G. A. Gioia, P. L. Wolters, J. Tonsgard, E. Schorry, D. Viskochil, L. Klesse, M. Fisher, D. H. Gutmann, A. J. Silva, S. J. Hunter, C. Rey-Casserly, N. L. Cantor, A. W. Byars, P. L. Stavinoha, J. D. Ackerson, C. L. Armstrong, J. Isenberg, S. H. O'Neil, R. J. Packer, B. Korf, M. T. Acosta, K. N. North and N. F. C. T. Consortium (2016). "Randomized placebo-controlled study of lovastatin in children with neurofibromatosis type 1." Neurology 87(24): 2575-2584.

198. Sahin, M., Henske, E.P., Manning, B.D., Ess, K.C., Bissler, J.J., Klann, E., Kwiatkowski, D.J., Roberds, S.L., Silva, A.J., Hillaire-Clarke, C.S., et al. (2016). Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference. Pediatr Neurol 60, 1-12. PMID: 27267556

199. Ibrahim, A.F.A., Montojo, C.A., Haut, K.M., Karlsgodt, K.H., Hansen, L., Congdon, E., Rosser, T., Bilder, R.M., Silva, A.J., and Bearden, C.E. (2017). Spatial working memory in neurofibromatosis 1: Altered neural activity and functional connectivity. Neuroimage Clin 15, 801-811. PMID: 28725547

200. Oh, J.Y., Rhee, S., Silva, A.J., Lee, Y.S., and Kim, H.K. (2017). Noonan syndrome-associated SHP2 mutation differentially modulates the expression of postsynaptic receptors according to developmental maturation. Neurosci Lett 649, 41-47. PMID: 28366775

201. Silva, A.J. (2017). Memory's Intricate Web: How One Memory Attaches to Another. Scientific American 317, 30-37. PMID:28632232

202. Silva, A.J. (2017). Miniaturized two-photon microscope: seeing clearer and deeper into the brain; Light: Science & Applications 6, e17104; doi:10.1038/lsa.2017.104; Published online 25 August 2017

203. Matiasz, N.J., Wood, J., Wang, W., Silva, A.J., and Hsu, W. (2017). Computer-Aided Experiment Planning toward Causal Discovery in Neuroscience. Front Neuroinform 11, 12. PMID: 28243197

204. Sehgal, M., Zhou, M., Cai, D.J., Lavi, A., Huang, S., & Silva, A.J. 4.35 - Mechanisms for Allocating, Tagging, and Linking Memories, In Learning and Memory: A Comprehensive Reference (Second Edition), edited by John H. Byrne,, Academic Press, Oxford, 2017, ISBN 9780128052914

205. Gonçalves, J, Violante, IR, Sereno, J, Leitão, RA, Cai, Y, Abrunhosa, A Silva, AP Silva, AJ, and Castelo-Branco, M. Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidenc for regional phenotypes. Molecular Autism (2017) 8:47

206. Jonas, R. K. et al. Risky Decision Making in Neurofibromatosis Type 1: An Exploratory Study. Biol Psychiatry Cogn Neurosci Neuroimaging 2, 170-179, doi:10.1016/j.bpsc.2016.12.003 (2017).

207. Lisman, John, Cooper, Katie, Segal, Megha, and Silva, Alcino J. Memory formation depends on both synapse specific modifications of synaptic strength and cell-specific increases in excitability. Nature Neuroscience 2018 Mar;21(3):309-314. doi: 10.1038/s41593-018-0076-6. Epub 2018 Feb 12.

208. Frank AC, Huang S, Zhou M, Gdalyahu A, Kastellakis G, Silva TK, Lu E, Wen X, Poirazi P, Trachtenberg JT, Silva AJ. Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory. Nat Commun. 2018 Jan 29;9(1):422. doi: 10.1038/s41467-017-02751-2. PMID: 29379017

209. Matiasz, N. J., J. Wood, P. Doshi, W. Speier, B. Beckemeyer, W. Wang, W. Hsu and A. J. Silva (2018). "ResearchMaps.org for integrating and planning research." PLoS One 13(5): e0195271.

210. Caracciolo, L., M. Marosi, J. Mazzitelli, S. Latifi, Y. Sano, L. Galvan, R. Kawaguchi, S. Holley, M. S. Levine, G. Coppola, C. Portera-Cailliau, A. J. Silva and S. T. Carmichael (2018). "CREB controls cortical circuit plasticity and functional recovery after stroke." Nat Commun. 2018 Jun 8;9(1):2250. doi: 10.1038/s41467-018-04445-9. PMID: 29884780

211. Liraz-Zaltsman, S., B. Slusher, D. Atrakchi-Baranes, K. Rosenblatt, Y. Friedman Levi, E. Kesner, A. J. Silva, A. Biegon and E. Shohami (2018). "Enhancement of Brain d-Serine Mediates Recovery of Cognitive Function after Traumatic Brain Injury." J Neurotrauma 35(14): 1667-1680.

212. Sehgal, M., M. Zhou, A. Lavi, S. Huang, Y. Zhou and A. J. Silva (2018). "Memory allocation mechanisms underlie memory linking across time." Neurobiol Learn Mem 153(Pt A): 21-25.

213. Stivaros, S., S. Garg, M. Tziraki, Y. Cai, O. Thomas, J. Mellor, A. A. Morris, C. Jim, K. Szumanska-Ryt, L. M. Parkes, H. A. Haroon, D. Montaldi, N. Webb, J. Keane, F. X. Castellanos, A. J. Silva, S. Huson, S. Williams, D. Gareth Evans, R. Emsley, J. Green and S. Consortium (2018). Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA)." Mol Autism 9: 12.

214. Hultman, R., K. Ulrich, B. D. Sachs, C. Blount, D. E. Carlson, N. Ndubuizu, R. C. Bagot, E. M. Parise, M. T. Vu, N. M. Gallagher, J. Wang, A. J. Silva, K. Deisseroth, S. D. Mague, M. G. Caron, E. J. Nestler, L. Carin and K. Dzirasa (2018). "Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability." Cell 173(1): 166-180 e114.

215. Howe, J. R. t., M. F. Bear, P. Golshani, E. Klann, S. A. Lipton, L. Mucke, M. Sahin and A. J. Silva (2018). "The mouse as a model for neuropsychiatric drug development." Curr Biol 28(17): R909-R914.

216. Aharoni, D., B. S. Khakh, A. J. Silva and P. Golshani (2019). "All the light that we can see: a new era in miniaturized microscopy." Nat Methods 16(1): 11-13.

217. Joy, M. T., E. Ben Assayag, D. Shabashov-Stone, S. Liraz-Zaltsman, J. Mazzitelli, M. Arenas, N. Abduljawad, E. Kliper, A. D. Korczyn, N. S. Thareja, E. L. Kesner, M. Zhou, S. Huang, T. K. Silva, N. Katz, N. M. Bornstein, A. J. Silva, E. Shohami and S. T. Carmichael (2019). "CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury." Cell 176(5): 1143-1157 e1113.

218. Ryu, H. H., T. Kim, J. W. Kim, M. Kang, P. Park, Y. G. Kim, H. Kim, J. Ha, J. E. Choi, J. Lee, C. S. Lim, C. H. Kim, S. J. Kim, A. J. Silva, B. K. Kaang and Y. S. Lee (2019). "Excitatory neuron-specific SHP2-ERK signaling network regulates synaptic plasticity and memory." Sci Signal 12(571).

219. Silva AJ, Bickle J. Memory linking and creativity: Molecular, cellular and circuit mechanisms. In: Nalbantian S, Matthews PM, editors. Secrets of Creativity:What Neuroscience, the Arts and our Minds Reveal. first ed. 198 Madison Av, NY, NY 10016, United States of America: Oxford University Press; 2019. p. 187-203.

220. Yetton, B. D., Cai, D. J., Spoormaker, V. I., Silva, A. J. & Mednick, S. C. Human Memories Can Be Linked by Temporal Proximity. Front Hum Neurosci 13, 315, doi:10.3389/fnhum.2019.00315 (2019).

221. Luchetti A, Chowdhury A, Silva AJ. Getting the full picture. Elife. 2019;8. Epub 2019/03/27. doi: 10.7554/eLife.46279. PubMed PMID: 30912744; PMCID: PMC6435316.

222. Shuman T, Aharoni D, Cai DJ, Lee CR, Chavlis S, Page-Harley L, Vetere LM, Feng Y, Yang CY, Mollinedo-Gajate I, Chen L, Pennington ZT, Taxidis J, Flores SE, Cheng K, Javaherian M, Kaba CC, Rao N, La-Vu M, Pandi I, Shtrahman M, Bakhurin KI, Masmanidis SC, Khakh BS, Poirazi P, Silva AJ, Golshani P. Breakdown of spatial coding and interneuron synchronization in epileptic mice. Nat Neurosci. 2020;23(2):229-38. Epub 2020/01/08. doi: 10.1038/s41593-019-0559-0. PubMed PMID: 31907437.

223. Friedman-Levi Y, Liraz-Zaltsman S, Shemesh C, Rosenblatt K, Kesner EL, Gincberg G, Carmichael ST, Silva AJ, Shohami E. Pharmacological blockers of CCR5 and CXCR4 improve recovery after traumatic brain injury. Exp Neurol. 2021;338:113604. Epub 2021/01/17. doi: 10.1016/j.expneurol.2021.113604. PubMed PMID: 33453212.

224. Liraz-Zaltsman S, Friedman-Levi Y, Shabashov-Stone D, Gincberg G, Atrakcy-Baranes D, Joy MT, Carmichael ST, Silva AJ, Shohami E. Chemokine Receptors CC Chemokine Receptor 5 and C-X-C Motif Chemokine Receptor 4 Are New Therapeutic Targets for Brain Recovery after Traumatic Brain Injury. J Neurotrauma. 2021. Epub 2020/12/02. doi: 10.1089/neu.2020.7015. PubMed PMID: 33256497.

225. de Sousa, A.F., A. Chowdhury, and A.J. Silva, Dimensions and mechanisms of memory organization. Neuron, 2021. 109(17): p. 2649-2662.

226. Manuel F. López-Aranda, Ishanu Chattopadhyay, Gayle M. Boxx, Elizabeth R. Fraley, Tawnie K Silva, Miou Zhou, Miranda Phan, Isaiah Herrera, Sunrae Taloma, Rochelle Mandanas1, Karen Bach, Michael Gandal, Daniel H. Geschwind, Genhong Cheng, Andrey Rzhetsky, Stephanie A. White, Alcino J. Silva. Early post-natal immune activation causes reversible social deficits in a mouse model of TSC: Mechanisms and clinical implications. Science Advances (2021), Vol 7, Issue 38 DOI: 10.1126/sciadv.abf2073229.

227. Wang, W., P.J. Schuette, M.Q. La-Vu, A. Torossian, B.C. Tobias, M. Ceko, P.A. Kragel, F.M. Reis, S. Ji, M. Sehgal, S. Maesta-Pereira, M. Chakerian, A.J. Silva, N.S. Canteras, T. Wager, J.C. Kao, and A. Adhikari, Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats. Elife, 2021. 10.

228. Wang W, Schuette PJ, La-Vu MQ, Torossian A, Tobias BC, Ceko M, Kragel PA, Reis FM, Ji S, Sehgal M, Maesta-Pereira S, Chakerian M, Silva AJ, Canteras NS, Wager T, Kao JC, Adhikari A. Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats. eLife. 2021;10. Epub 2021/09/02. doi: 10.7554/eLife.69178. PubMed PMID: 34468312.

229. Sehgal M, Almeida Filho D, Martin S, Mejia ID, Kastellakis G, Kim S, Lee J, Pekcan A, Huang S, Lavi A, Heo WD, Poirazi P, Trachtenberg JT, Silva AJ. Co-allocation to overlapping dendritic branches in the retrosplenial cortex integrates contextual memories across time bioRxiv. 2021. Epub November 1, 2021. doi:bioRxiv 2021.10.28.466343; doi: https://doi.org/10.1101/2021.10.28.466343

230. Matiasz NJ, Wood J, Wang W, Silva AJ, Hsu W. Experiment Selection in Meta-Analytic Piecemeal Causal Discovery. IEEE Access. 2021;9:97929-97941. doi: 10.1109/access.2021.3093524. Epub 2021 Jul 1. PMID: 34532201

231. Meenakshi P., D. Mehrotra, N. Nruthyathi, D. Almeida-Filho, Y.-S. Lee, A.J. Silva, and J. Balaji. Novel measures of Morris water maze performance that use vector field maps to assess accuracy, uncertainty, and intention of navigational searches. Hippocampus 2022 Apr;32(4):264-285. doi: 10.1002/hipo.23404. Epub 2022 Jan 13.

232. Yang Shen, Alessandro Luchetti, Won Do Heo, Alcino J. Silva. The Emergence of Molecular Systems Neuroscience. Molecular Brain volume 15, Article number: 7 (2022)

233. J Wood, NJ Matiasz, AJ Silva, A.A. W Hsu, and W. Wang., OpBerg: Discovering causal sentences using optimal alignments., in Big Data Analytics and Knowledge Discovery, R. Wrembel, et al., Editors. 2022, Springer: Gewerbestrasse 11, 6330 Cham, Switzerland. p. 17-31.

234. Silva, AJ, "Dissemination and adaptiveness as key variables in tools that fuel scientific revolutions" in The Tools of Neuroscience Experiments: Philosophical and Scientific Perspectives, Routledge Press, 1st Edition, eBook ISBN 9781003251392 (2021)

235. Lopez-Aranda, M.F., T.K. Silva, M. Zhou, M. Phan, I. Herrera, S. Taloma, R. Mandanas, K. Bach, and A.J. Silva, Role of type I interferon signaling and microglia in the abnormal long-term potentiation and object place recognition deficits of male mice with a mutation of the Tuberous Sclerosis 2 gene Biological Psychiatry:GOS Biological Psychiatry Global Open Science,2022,ISSN 2667-1743, https://doi.org/10.1016/j.bpsgos.2022.03.015.

236. Yang Shen, Miou Zhou1, Denise Cai Daniel Almeida Filho, Giselle Fernandes, Ying Cai, Nury Kim, Deanna Necula, Chengbin Zhou, Andy Liu, Xiaoman Kang, Masakazu Kamata, Ayal Lavi, Shan Huang, Tawnie Silva, Won Do Heo, Alcino J. Silva. CCR5 closes the temporal window for memory linking. Nature. 2022 Jun;606(7912):146-152. doi: 10.1038/s41586-022-04783-1. Epub 2022 May 25.PMID: 35614219

237. Chowdhury A, Luchetti A, Fernandes G, Almeida Filho D, Tzilivaki A, Kastellakis G, Ramirez E, Tran MM, Poirazi P, Silva AJ. A role for the Locus Coeruleus dorsal CA1 dopaminergic projection in the modulation of contextual memory ensembles and contextual memory linking. Neuron 2022, Aug 24;S0896-6273(22)00707-3. doi: 10.1016/j.neuron.2022.08.001; PMID: 36041433

238. Lavi, A., Sisan, F., Okabe, A., Ter-Mkrychyan, D., Sehgal, M., Silva, A.J. Local memory allocation recruits memory ensembles across brain regions. Neuron 2023 Feb 15;111(4):470-480.e5. doi: 10.1016/j.neuron.2022.11.018. Epub 2022 Dec 22. PMID: 36563678

239. Bickle, J., De Sousa, A.F., Silva, A.J. New research tools suggest a “levels-less” image of the behaving organism and a dissolution of the reduction versus anti-reduction dispute. Frontiers Front Psychol 2022 Aug 29;13:990316. doi: 10.3389/fpsyg.2022.990316. eCollection 2022

240. Changliang Guo, Garrett Blair, Megha Sehgal, Federico N. Sangiuliano Jimka, Arash Bellafard, Alcino J. Silva, Peyman Golshani, Michele A. Basso, H. Tad Blair, and Daniel Aharoni. Miniscope-LFOV: A large field of view, single cell resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals. Science Advances 2023 Apr 21;9(16):eadg3918. doi: 10.1126/sciadv.adg3918. Epub 2023 Apr 21.

241. Yosif Zaki, Zachary Pennington, Denisse Morales-Rodriguez, Taylor Francisco, Alexa LaBanca, Zhe Dong, Simon Carrillo Segura, Alcino J. Silva, Tristan Shuman, Andre Fenton, Kanaka Rajan, Denise J. Cai1* Aversive experience drives offline ensemble reactivation to link memories across days. doi:bioRxiv 2023

242. Fernando Reis, Sandra Maesta-Pereira, Matthias Ollivier, Peter Schuette, Ekayana Sethi, Emily Iniguez, Meghmik Chakerian, Eric Vaughn, Megha Sehgal, Darren Nguyen, Faith Yuan, Anita Torossian, Juliane Ikebara, Alexandre Kihara, Alcino Silva, Jonathan Kao, Baljit Khakh, Blake Miranda, and Avishek Adhikari. Control of feeding by a bottom-up midbrain-subthalamic pathway. Nat Comm 15, 2024 Mar 7;15(1):2111. PMID: 38454000 PMCID: PMC10920831; DOI: 10.1038/s41467-024-46430-5

243. Manuel F López-Aranda, Karen Bach, Raymond Bui, Miranda Phan, Odilia Lu, Chirag Thadani, Alessandro Luchetti, Rochelle Mandanas, Isaiah Herrera, María Dolores López-Ávalos, Alcino J Silva. Early Post-Natal Immune Activation Leads to Object Memory Deficits in Female Tsc2+/- Mice: The Importance of Including Both Sexes in Neuroscience Research. Biomedicines. 2024 Jan 17;12(1):203. doi:10.3390/biomedicines12010203. PMID: 38255309 PMCID: PMC10813674 DOI: 10.3390/biomedicines12010203

244. Yosif Zaki, Zachary T. Pennington, Denisse Morales-Rodriguez, Madeline Bacon, BumJin Ko, Taylor R. Francisco, Alexa R. LaBanca, Patlapa Sompolpong, Zhe Dong, Sophia Lamsifer, Hung-Tu Chen, Simón Carrillo Segura, Zoé Christenson Wick, Alcino J. Silva, Kanaka Rajan, Matthijs van der Meer, André Fenton, Tristan Shuman, Denise J. Cai. Offline ensemble co-reactivation links memories across days. Nature. 2025 Jan;637(8044):145-155. doi: 10.1038/s41586-024-08168-4. Epub 2024 Nov 6.PMID: 39506117

245. Nicholas J. Matiasz, Justin Wood, and Alcino J. Silva; Quantifying convergence and consistency; Eur J Neurosci. 2024 Nov;60(10):6391-6394. doi: 10.1111/ejn.16561. Epub 2024 Oct 15.PMID: 39403790

246. Giovanniello JR, Paredes N, Wiener A, Ramírez-Armenta K, Oragwam C, Uwadia HO, Yu AL, Lim K, Pimenta JS, Vilchez GE, Nnamdi G, Wang A, Sehgal M, Reis FM, Sias AC, Silva AJ, Adhikari A, Malvaez M, Wassum KM. A dual-pathway architecture for stress to disrupt agency and promote habit.Nature. 2025 Feb 19. doi: 10.1038/s41586-024-08580-w. PMID: 39972126

247. Sehgal M, Filho DA, Kastellakis G, Kim S, Lee J, Shen Y, Huang S, Lavi A, Fernandes G, Davila Mejia I, Martin SS, Pekcan A, Wu MS, Heo WD, Poirazi P, Trachtenberg JT, Silva AJ. Compartmentalized dendritic plasticity in the mouse retrosplenial cortex links contextual memories formed close in time. Nat Neurosci. 2025 Mar;28(3):602-615. doi: 10.1038/s41593-025-01876-8. Epub 2025 Feb 17. PMID: 39962274