Posts classified under: Faculty

Research Interests

The future aint what it used to be – Yogi Berra It is precisely because the future is unpredictable that the mammalian brain has evolved the capacity to acquire new information through sensory experiences, store this information as memories, and rapidly retrieve this information to modify behavior. But how do novel sensory experiences embed themselves in the fabric of the brain to form memories? This question drives the research in my laboratory, which examines the cellular and synaptic mechanisms of experience-dependent plasticity in the neocortex. Specifically, I am interested in understanding i) where experience-dependent plasticity is initiated in the cortical circuitry; ii) how experience regulates the growth or retraction of synapses; iii) whether plasticity is restricted to only a subset of synaptic connections; iv) what distinguishes “critical period” plasticity from adult plasticity; v) how synaptic plasticity is altered in the aging and diseased brain. Techniques: To address these qustions, I use: 2-photon laser scanning microscopy to repeatedly image neurons, synapses, and proteins in the living brain of mice over periods of weeks 2-photon microscopy to acutely image cellular responses to sensory stimuli using calcium imaging. Intrinsic signal optical imaging to non-invasively and repeatedly image stimulus-induced responses in populations of neurons in the intact, living brain. Microelectrodes to monitor changes in neuronal responses to visual stimuli before and after a plasticity paradigm and to determine the laminar position of these changes Using these techniques, I directly examine experience-dependent changes in structure and function in the same cortical region. Understanding how synapse formation and elimination is regulated by experience and their roles in learning and memory is critically important to developing rationally-based therapeutic approaches to diseases such as Alzheimer’s disease, and related dementias, in which cognitive impairment is strongly correlated with a loss of synapses in the cortex. Biography Joshua Trachtenberg joined the Department of Neurobiology as an Assistant Professor in July of 2003. His research focuses on understanding the cellular and circuit-wide mechanisms that underlie the acquisition and consolidation of memories in the cortex. Prior to joining the UCLA faculty, he was a postdoctoral fellow at the Cold Spring Harbor Laboratory and at the University of California, San Francisco. He received his Ph.D. in developmental neurobiology at the University of Texas at Austin and his Bachelor of Arts degree from Brandeis University.

Publications

Kuhlman Sandra J, Olivas Nicholas D, Tring Elaine, Ikrar Taruna, Xu Xiangmin, Trachtenberg Joshua T A disinhibitory microcircuit initiates critical-period plasticity in the visual cortex. Nature. 2013; 501(7468): 543-6.

Gdalyahu Amos, Tring Elaine, Polack Pierre-Olivier, Gruver Robin, Golshani Peyman, Fanselow Michael S, Silva Alcino J, Trachtenberg Joshua T Associative fear learning enhances sparse network coding in primary sensory cortex. Neuron. 2012; 75(1): 121-32.

Wyatt Ryan M, Tring Elaine, Trachtenberg Joshua T Pattern and not magnitude of neural activity determines dendritic spine stability in awake mice. Nature neuroscience. 2012; 15(7): 949-51.

Kuhlman Sandra J, Tring Elaine, Trachtenberg Joshua T Fast-spiking interneurons have an initial orientation bias that is lost with vision. Nature neuroscience. 2011; 14(9): 1121-3.

Smith Spencer L, Trachtenberg Joshua T The refinement of ipsilateral eye retinotopic maps is increased by removing the dominant contralateral eye in adult mice. PloS one. 2010; 5(3): e9925.

Matter Cheryl, Pribadi Mochtar, Liu Xin, Trachtenberg Joshua T Delta-catenin is required for the maintenance of neural structure and function in mature cortex in vivo. Neuron. 2009; 64(3): 320-7.

Faguet J, Maranhao B, Smith SL, Trachtenberg JT Ipsilateral eye cortical maps are uniquely sensitive to binocular plasticity. Journal of Neurophysiology 2009; 101(2): 855-61.

Chow DK, Groszer M, Pribadi M, Machniki M, Carmichael ST, Liu X, Trachtenberg JT Laminar and compartmental regulation of dendritic growth in vivo. Nature Neuroscience 2009; 12(2): 116-8.

Li W, Zhou Y, Jentsch JD, Brown RA, Tian X, Ehninger D, Hennah W, Peltonen L, Lonnqvist J, Huttunen MO, Kaprio J, Trachtenberg JT, Silva AJ, Cannon TD. Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci U S A 2007; 104(46): 18280-5.

Smith SL & Trachtenberg JT Experience-dependent binocular competition in the visual cortex begins at eye opening. Nature Neuroscience 2007; 10(3): 370-375. Download

Holtmaat, AJ Trachtenberg, JT Wilbrecht, L Shepherd, GM Zhang, X Knott, GW Svoboda, K Transient and persistent dendritic spines in the neocortex in vivo. Neuron. . 2005; 45(2): 279-91. Download

Trachtenberg JT, Chen BE, Knott GW, Feng G, Sanes JR, Welker E, Svoboda K Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature. . 2002; 420(6917): 788-94. Download

Trachtenberg, JT Stryker, MP Rapid anatomical plasticity of horizontal connections in the developing visual cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2001; 21(10): 3476-82. Download

Trachtenberg, JT Trepel, C Stryker, MP Rapid extragranular plasticity in the absence of thalamocortical plasticity in the developing primary visual cortex. Science. . 2000; 287(5460): 2029-32. Download

Issa, NP Trachtenberg, JT Chapman, B Zahs, KR Stryker, MP The critical period for ocular dominance plasticity in the Ferret’s visual cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1999; 19(16): 6965-78.

Trachtenberg, JT Fiber apoptosis in developing rat muscles is regulated by activity, neuregulin. Developmental biology. . 1998; 196(2): 193-203.

Trachtenberg, JT Thompson, WJ Nerve terminal withdrawal from rat neuromuscular junctions induced by neuregulin and Schwann cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1997; 17(16): 6243-55.

Son, YJ Trachtenberg, JT Thompson, WJ Schwann cells induce and guide sprouting and reinnervation of neuromuscular junctions. Trends in neurosciences. . 1996; 19(7): 280-5.

Trachtenberg, JT Thompson, WJ Schwann cell apoptosis at developing neuromuscular junctions is regulated by glial growth factor. Nature. . 1996; 379(6561): 174-7.

Biography

Alcino Silva was born in Portugal in 1961, but his family moved to Luanda, Angola, when he was 3 years old. He came to the United States to attend Rutgers University in 1979. There, he worked with William Sofer on Drosophila tRNA non-sense suppressors and minored on philosophy (epistemology). In 1983 he joined the graduate program of human genetics at the University of Utah, where he worked with Ray White, a pioneer in Human Genetics, on the inheritance of epigenetic information (Silva et al, 1988; Cell PMID: 2898978). While a graduate student, Dr. Silva organized yearly graduate symposia where leading luminaries from the Arts and Sciences shared their insights on the nature of innovation and creativity. During his post-doctoral work at the Massachusetts Institute of Technology with Nobel Laureate Dr. Susumu Tonegawa (1988-92), Dr. Alcino J. Silva introduced transgenic mice to neuroscience studies of learning and memory and pioneered the field of Molecular and Cellular Cognition (Silva et al, Science 1992, PMIDs 1321493 &1378648). His first independent position (1992) was with the Cold Spring Harbor Laboratory, NY, where his research group had a key role in the development of Molecular and Cellular Cognition into a mainstream neuroscience field. In 2002 Dr. Silva founded and became the first President of the Molecular and Cellular Cognition Society, an international organization with more than 4000 members and with branches in North America, Asia and Europe. Besides work on molecular and cellular cognition, his laboratory also works on developing approaches for systematic studies of scientific practices. The goal is to develop pragmatic, validated, general principles for increasing the efficiency of science. In 2006/2007 Dr. Silva served as Scientific Director of the Intramural Program of the National Institute of Mental Health. He is currently Professor of Neurobiology, Psychiatry & Biobehavioral Sciences, and Psychology. He currently heads the Center for Genetic Studies of Cortical Plasticity, and serves as the co-director of Plasticity and Learning studies at UCLA. He also serves in the Board of Regents of the University of Minho, Portugal. He has been awarded a number of prizes and distinctions, including most recently the Order of Prince Henry (2008), the highest award given by the Portuguese Government to a Private citizen, the Marco Canavezes Medal of Science (2008), and the Senior Roche Award For Translational Neuroscience (2009).

Publications

Silva Alcino J, Müller Klaus-Robert The need for novel informatics tools for integrating and planning research in molecular and cellular cognition Learning & memory (Cold Spring Harbor, N.Y.), 2015; 22(9): 494-8.

Korf Bruce, Ahmadian Reza, Allanson Judith, Aoki Yoko, Bakker Annette, Wright Emma Burkitt, Denger Brian, Elgersma Ype, Gelb Bruce D, Gripp Karen W, Kerr Bronwyn, Kontaridis Maria, Lazaro Conxi, Linardic Corinne, Lozano Reymundo, MacRae Calum A, Messiaen Ludwine, Mulero-Navarro Sonia, Neel Benjamin, Plotkin Scott, Rauen Katherine A, Roberts Amy, Silva Alcino J, Sittampalam Sitta G, Zhang Chao, Schoyer Lisa The third international meeting on genetic disorders in the RAS/MAPK pathway: Towards a therapeutic approach American journal of medical genetics. Part A, 2015; 167(8): 1741-6.

Silva Alcino Alcino Silva Current biology : CB, 2015; 25(10): R394-7. Kastellakis George, Cai Denise J, Mednick Sara C, Silva Alcino J, Poirazi Panayiota Synaptic clustering within dendrites: an emerging theory of memory formation Progress in neurobiology, 2015; 126(10): 19-35.

Sano Yoshitake, Shobe Justin L, Zhou Miou, Huang Shan, Shuman Tristan, Cai Denise J, Golshani Peyman, Kamata Masakazu, Silva Alcino J CREB regulates memory allocation in the insular cortex Current biology : CB, 2014; 24(23): 2833-7.

Lee Yong-Seok, Ehninger Dan, Zhou Miou, Oh Jun-Young, Kang Minkyung, Kwak Chuljung, Ryu Hyun-Hee, Butz Delana, Araki Toshiyuki, Cai Ying, Balaji J, Sano Yoshitake, Nam Christine I, Kim Hyong Kyu, Kaang Bong-Kiun, Burger Corinna, Neel Benjamin G, Silva Alcino J Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome Nature neuroscience, 2014; 17(12): 1736-43.

Le Belle Janel E, Sperry Jantzen, Ngo Amy, Ghochani Yasmin, Laks Dan R, López-Aranda Manuel, Silva Alcino J, Kornblum Harley I Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells Stem cell reports, 2014; 3(5): 725-34.

Czajkowski Rafał, Jayaprakash Balaji, Wiltgen Brian, Rogerson Thomas, Guzman-Karlsson Mikael C, Barth Alison L, Trachtenberg Joshua T, Silva Alcino J Encoding and storage of spatial information in the retrosplenial cortex Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(23): 8661-6.

Rogerson Thomas, Cai Denise J, Frank Adam, Sano Yoshitake, Shobe Justin, Lopez-Aranda Manuel F, Silva Alcino J Synaptic tagging during memory allocation Nature reviews. Neuroscience, 2014; 15(3): 157-69.

Landreth Anthony, Silva Alcino J The need for research maps to navigate published work and inform experiment planning Neuron, 2013; 79(3): 411-5.

Zhou Miou, Li Weidong, Huang Shan, Song Juan, Kim Ju Young, Tian Xiaoli, Kang Eunchai, Sano Yoshitake, Liu Cindy, Balaji J, Wu Shumin, Zhou Yu, Zhou Ying, Parivash Sherveen N, Ehninger Dan, He Lin, Song Hongjun, Ming Guo-Li, Silva Alcino J mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons Neuron, 2013; 77(4): 647-54.

Gutmann David H, Parada Luis F, Silva Alcino J, Ratner Nancy Neurofibromatosis type 1: modeling CNS dysfunction The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(41): 14087-93.

Acosta Maria T, Bearden Carrie E, Castellanos F Xavier, Castellanos Xavier F, Cutting Laurie, Elgersma Ype, Gioia Gerard, Gutmann David H, Lee Yong-Seok, Legius Eric, Muenke Maximillian, North Kathryn, Parada Luis F, Ratner Nancy, Hunter-Schaedle Kim, Silva Alcino J The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research American journal of medical genetics. Part A, 2012; 158A(9): 2225-32.

Gdalyahu Amos, Tring Elaine, Polack Pierre-Olivier, Gruver Robin, Golshani Peyman, Fanselow Michael S, Silva Alcino J, Trachtenberg Joshua T Associative fear learning enhances sparse network coding in primary sensory cortex Neuron, 2012; 75(1): 121-32.

Cho Jeiwon, Bhatt Rushi, Elgersma Ype, Silva Alcino J α-Calcium calmodulin kinase II modulates the temporal structure of hippocampal bursting patterns PloS one, 2012; 7(2): e31649.

Karlsgodt Katherine H, Rosser Tena, Lutkenhoff Evan S, Cannon Tyrone D, Silva Alcino, Bearden Carrie E Alterations in white matter microstructure in neurofibromatosis-1 PloS one, 2012; 7(10): e47854.

Silva Alcino J A career that transformed neuroscience Brain research bulletin, 2011; 7(2): .

Ehninger Dan, Silva Alcino J Increased levels of anxiety-related behaviors in a Tsc2 dominant negative transgenic mouse model of tuberous sclerosis Behavior genetics, 2011; 41(3): 357-63.

Lee Yong-Seok, Silva Alcino J Modeling hyperactivity: of mice and men Nature medicine, 2011; 17(5): 541-2.

Kye Min Jeong, Neveu Pierre, Lee Yong-Seok, Zhou Miou, Steen Judith A, Sahin Mustafa, Kosik Kenneth S, Silva Alcino J NMDA mediated contextual conditioning changes miRNA expression PloS one, 2011; 6(9): e24682. Kaneko Megumi, Cheetham Claire E, Lee Yong-Seok, Silva Alcino J, Stryker Michael P, Fox Kevin Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(44): 19026-31.

Shilyansky Carrie, Karlsgodt Katherine H, Cummings Damian M, Sidiropoulou Kyriaki, Hardt Molly, James Alex S, Ehninger Dan, Bearden Carrie E, Poirazi Panayiota, Jentsch J David, Cannon Tyrone D, Levine Michael S, Silva Alcino J Neurofibromin regulates corticostriatal inhibitory networks during working memory performance Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(29): 13141-6.

Feng Jian, Zhou Yu, Campbell Susan L, Le Thuc, Li En, Sweatt J David, Silva Alcino J, Fan Guoping Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons Nature neuroscience, 2010; 13(4): 423-30.

Matynia Anna, Ng Carina Hoi, Dansithong Warunee, Chiang Andy, Silva Alcino J, Reddy Sita Muscleblind1, but not Dmpk or Six5, contributes to a complex phenotype of muscular and motivational deficits in mouse models of myotonic dystrophy PloS one, 2010; 5(3): e9857.

Zhou Yu, Won Jaejoon, Karlsson Mikael Guzman, Zhou Miou, Rogerson Thomas, Balaji Jayaprakash, Neve Rachael, Poirazi Panayiota, Silva Alcino J CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala Nature neuroscience, 2009; 12(11): 1438-43.

Silva Alcino J, Zhou Yu, Rogerson Thomas, Shobe Justin, Balaji J Molecular and cellular approaches to memory allocation in neural circuits Science (New York, N.Y.), 2009; 326(5951): 391-5.

Hutnick Leah K, Golshani Peyman, Namihira Masakasu, Xue Zhigang, Matynia Anna, Yang X William, Silva Alcino J, Schweizer Felix E, Fan Guoping DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation Human molecular genetics, 2009; 18(15): 2875-88.

Ehninger Dan, Silva Alcino J Genetics and neuropsychiatric disorders: treatment during adulthood Nature medicine, 2009; 15(8): 849-50.

Silva Alcino J, Ehninger Dan Adult reversal of cognitive phenotypes in neurodevelopmental disorders Journal of neurodevelopmental disorders, 2009; 1(2): 150-7.

Lee Yong-Seok, Silva Alcino J The molecular and cellular biology of enhanced cognition Nature reviews. Neuroscience, 2009; 10(2): 126-40.

Ehninger Dan, Li Weidong, Fox Kevin, Stryker Michael P, Silva Alcino J Reversing neurodevelopmental disorders in adults Neuron, 2008; 60(6): 950-60.

Cui Yijun, Costa Rui M, Murphy Geoffrey G, Elgersma Ype, Zhu Yuan, Gutmann David H, Parada Luis F, Mody Istvan, Silva Alcino J Neurofibromin regulation of ERK signaling modulates GABA release and learning Cell, 2008; 135(3): 549-60.

Ehninger Dan, Han Sangyeul, Shilyansky Carrie, Zhou Yu, Li Weidong, Kwiatkowski David J, Ramesh Vijaya, Silva Alcino J Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis Nature medicine, 2008; 14(8): 843-8.

Matynia Anna, Anagnostaras Stephan G, Wiltgen Brian J, Lacuesta Maress, Fanselow Michael S, Silva Alcino J A high through-put reverse genetic screen identifies two genes involved in remote memory in mice PloS one, 2008; 3(5): e2121.

Won Jaejoon, Silva Alcino J Molecular and cellular mechanisms of memory allocation in neuronetworks Neurobiology of learning and memory, 2008; 89(3): 285-92.

Zhou Yu, Takahashi Eiki, Li Weidong, Halt Amy, Wiltgen Brian, Ehninger Dan, Li Guo-Dong, Hell Johannes W, Kennedy Mary B, Silva Alcino J Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(50): 13843-53.

Li Weidong, Zhou Yu, Jentsch J David, Brown Robert A M, Tian Xiaoli, Ehninger Dan, Hennah William, Peltonen Leena, Lönnqvist Jouko, Huttunen Matti O, Kaprio Jaakko, Trachtenberg Joshua T, Silva Alcino J, Cannon Tyrone D Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(46): 18280-5.

Silva Alcino J The science of research: the principles underlying the discovery of cognitive and other biological mechanisms Journal of physiology, Paris, 2007; 101(4-6): 203-13.

Wiltgen Brian J, Silva Alcino J Memory for context becomes less specific with time Learning & memory (Cold Spring Harbor, N.Y.), 2007; 14(4): 313-7.

Murphy Geoffrey G, Rahnama Nancy P, Silva Alcino J Investigation of age-related cognitive decline using mice as a model system: behavioral correlates The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2006; 14(12): 1004-11.

Murphy Geoffrey G, Shah Vaibhavi, Hell Johannes W, Silva Alcino J Investigation of age-related cognitive decline using mice as a model system: neurophysiological correlates The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2006; 14(12): 1012-21.

Chen Adele P, Ohno Masuo, Giese K Peter, Kühn Ralf, Chen Rachel L, Silva Alcino J Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory Journal of neuroscience research, 2006; 83(1): 28-38.

Li Weidong, Cui Yijun, Kushner Steven A, Brown Robert A M, Jentsch J David, Frankland Paul W, Cannon Tyrone D, Silva Alcino J The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1 Current biology : CB, 2005; 15(21): 1961-7.

Kushner Steven A, Elgersma Ype, Murphy Geoffrey G, Jaarsma Dick, van Woerden Geeske M, Hojjati Mohammad Reza, Cui Yijun, LeBoutillier Janelle C, Marrone Diano F, Choi Esther S, De Zeeuw Chris I, Petit Ted L, Pozzo-Miller Lucas, Silva Alcino J Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005; 25(42): 9721-34.

Costa Rui M, Drew Camilla, Silva Alcino J Notch to remember Trends in neurosciences, 2005; 28(8): 429-35. Ehninger Dan, Matynia Anna, Silva Alcino J Trafficking in emotions Nature neuroscience, 2005; 8(5): 548-50.

Murphy Geoffrey G, Fedorov Nikolai B, Giese K Peter, Ohno Masuo, Friedman Eugenia, Chen Rachel, Silva Alcino J Increased neuronal excitability, synaptic plasticity, and learning in aged Kvbeta1.1 knockout mice Current biology : CB, 2004; 14(21): 1907-15.

Israely Inbal, Costa Rui M, Xie Cui Wei, Silva Alcino J, Kosik Kenneth S, Liu Xin Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction Current biology : CB, 2004; 14(18): 1657-63.

Wiltgen Brian J, Brown Robert A M, Talton Lynn E, Silva Alcino J New circuits for old memories: the role of the neocortex in consolidation Neuron, 2004; 44(1): 101-8.

Suzuki Akinobu, Josselyn Sheena A, Frankland Paul W, Masushige Shoichi, Silva Alcino J, Kida Satoshi Memory reconsolidation and extinction have distinct temporal and biochemical signatures The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004; 24(20): 4787-95.

Frankland Paul W, Bontempi Bruno, Talton Lynn E, Kaczmarek Leszek, Silva Alcino J The involvement of the anterior cingulate cortex in remote contextual fear memory Science (New York, N.Y.), 2004; 304(5672): 881-3.

Frankland Paul W, Josselyn Sheena A, Anagnostaras Stephan G, Kogan Jeffrey H, Takahashi Eiki, Silva Alcino J Consolidation of CS and US representations in associative fear conditioning Hippocampus, 2004; 14(5): 557-69.

Brown Robert, Silva Alcino J Molecular and cellular cognition; the unraveling of memory retrieval Cell, 2004; 117(1): 3-4. Costa Rui M, Honjo Tasuku, Silva Alcino J Learning and memory deficits in Notch mutant mice Current biology : CB, 2003; 13(15): 1348-54.

Frankland Paul W, Ohno Masuo, Takahashi Eiki, Chen Adele R, Costa Rui M, Kushner Steven A, Silva Alcino J Pharmacologically regulated induction of silent mutations (PRISM): combined pharmacological and genetic approaches for learning and memory The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2003; 9(2): 104-9.

Dhaka Ajay, Costa Rui M, Hu Hailiang, Irvin Dwain K, Patel Apoor, Kornblum Harley I, Silva Alcino J, O’Dell Thomas J, Colicelli John The RAS effector RIN1 modulates the formation of aversive memories The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003; 23(3): 748-57.

Silva Alcino J Molecular and cellular cognitive studies of the role of synaptic plasticity in memory Journal of neurobiology, 2003; 54(1): 224-37. Costa Rui M, Silva Alcino J Mouse models of neurofibromatosis type I: bridging the GAP Trends in molecular medicine, 2003; 9(1): 19-23.

Anagnostaras Stephan G, Murphy Geoffrey G, Hamilton Susan E, Mitchell Scott L, Rahnama Nancy P, Nathanson Neil M, Silva Alcino J Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice Nature neuroscience, 2003; 6(1): 51-8.

Elgersma Ype, Fedorov Nikolai B, Ikonen Sami, Choi Esther S, Elgersma Minetta, Carvalho Ofelia M, Giese Karl Peter, Silva Alcino J Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning Neuron, 2002; 36(3): 493-505.

Costa Rui M, Silva Alcino J Molecular and cellular mechanisms underlying the cognitive deficits associated with neurofibromatosis 1 Journal of child neurology, 2002; 17(8): 622-6; discussion 627-9, 646-51.

Silva Alcino J, Josselyn Sheena A The molecules of forgetfulness Nature, 2002; 418(6901): 929-30.

Ohno Masuo, Frankland Paul W, Silva Alcino J A pharmacogenetic inducible approach to the study of NMDA/alphaCaMKII signaling in synaptic plasticity Current biology : CB, 2002; 12(8): 654-6.

Kida Satoshi, Josselyn Sheena A, Peña de Ortiz Sandra, Kogan Jeffrey H, Chevere Itzamarie, Masushige Shoichi, Silva Alcino J CREB required for the stability of new and reactivated fear memories Nature neuroscience, 2002; 5(4): 348-55.

Givogri Maria I, Costa Rui M, Schonmann Vilma, Silva Alcino J, Campagnoni Anthony T, Bongarzone Ernesto R Central nervous system myelination in mice with deficient expression of Notch1 receptor Journal of neuroscience research, 2002; 67(3): 309-20.

Matynia Anna, Kushner Steven A, Silva Alcino J Genetic approaches to molecular and cellular cognition: a focus on LTP and learning and memory Annual review of genetics, 2002; 36(6871): 687-720.

Costa Rui M, Federov Nikolai B, Kogan Jeff H, Murphy Geoffrey G, Stern Joel, Ohno Masuo, Kucherlapati Raju, Jacks Tyler, Silva Alcino J Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1 Nature, 2002; 415(6871): 526-30.

Research Interest

Visual neurophysiology and perception

Publications

Lopour Beth A, Tavassoli Abtine, Fried Itzhak, Ringach Dario L Coding of information in the phase of local field potentials within human medial temporal lobe Neuron, 2013; 79(3): 594-606.

Paik Se-Bum, Ringach Dario L Link between orientation and retinotopic maps in primary visual cortex Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(18): 7091-6.

Nauhaus Ian, Busse Laura, Ringach Dario L, Carandini Matteo Robustness of traveling waves in ongoing activity of visual cortex The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(9): 3088-94.

Frey Jared, Ringach Dario L Binocular eye movements evoked by self-induced motion parallax The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(47): 17069-73.

Paik Se-Bum, Ringach Dario L Retinal origin of orientation maps in visual cortex Nature neuroscience, 2011; 14(7): 919-25.

Ringach Dario L The use of nonhuman animals in biomedical research The American journal of the medical sciences, 2011; 342(4): 305-13.

Ringach Dario L You get what you get and you don’t get upset Nature neuroscience, 2011; 14(2): 123-4.

Pouget Alexander, Ringach Dario L, Landy Michael Data rules; but theory understands: an introduction to a special issue on “Mathematical models of visual coding” Vision research, 2010; 50(22): 2189.

Ringach Dario L Population coding under normalization Vision research, 2010; 50(22): 2223-32.

Theobald Jamie C, Ringach Dario L, Frye Mark A Visual stabilization dynamics are enhanced by standing flight velocity Biology letters, 2010; 6(3): 410-3.

Malone BJ, Ringach DL. Dynamics of tuning in the Fourier domain, J Neurophysiol, 2008; 100(1): 239-48.

Theobald JC, Duistermars BJ, Ringach DL, Frye MA. Flies see second-order motion, Curr Biol, 2008; 18(11): R464-5.

Nauhaus I, Benucci A, Carandini M, Ringach DL. Neuronal selectivity and local map structure in visual cortex, Neuron, 2008; 57(5): 673-9.

Malone BJ, Kumar VR, Ringach DL. Dynamics of receptive field size in primary visual cortex, J Neurophysiol, 2007; 97(1): 407-14. Ringach DL. On the origin of the functional architecture of the cortex, PLoS ONE, 2007; 28(2): e251.

Nauhaus I, Ringach DL. Precise alignment of micromachined electrode arrays with V1 functional maps, J Neurophysiol, 2007; 97(5): 3781-9.

Ringach DL, Malone BJ. The operating point of the cortex: neurons as large deviation detectors, J Neurosci, 2007; 27(29): 7673-83.

Xing D, Shapley RM, Hawken MJ, Ringach DL. Effect of stimulus size on the dynamics of orientation selectivity in Macaque V1, J Neurophysiol, 2005; 94(1): 799-812.

Mata ML, Ringach DL. Spatial overlap of ON and OFF subregions and its relation to response modulation ratio in macaque primary visual cortex, J Neurophysiol, 2005; 93(2): 919-28.

Xing D, Ringach DL, Shapley R, Hawken MJ. Correlation of local and global orientation and spatial frequency tuning in macaque V1, J Physiol, 2004; 557(Pt 3): 923-33.

Ringach DL. Haphazard wiring of simple receptive fields and orientation columns in visual cortex, J Neurophysiol, 2004; 92(1): 468-76.

Ringach DL. Mapping receptive fields in primary visual cortex, J Physiol, 2004; 558(Pt 3): 717-28.

Shapley R, Hawken M, Ringach DL. Dynamics of orientation selectivity in the primary visual cortex and the importance of cortical inhibition, Neuron, 2003; 38(5): 689-99.

Ringach, DL Hawken, MJ Shapley, R Dynamics of orientation tuning in macaque V1: the role of global and tuned suppression Journal of neurophysiology. , 2003; 90(1): 342-52.

Dorn JD, Ringach DL. Estimating membrane voltage correlations from extracellular spike trains, J Neurophysiol, 2003; 89(4): 2271-8.

Dorn, JD Ringach, DL Estimating membrane voltage correlations from extracellular spike trains Journal of neurophysiology. , 2003; 89(4): 2271-8.

Ringach DL. Look at the big picture (details will follow), Nat Neurosci, 2003; 6(1): 7-8.

Ringach DL. Neuroscience: states of mind, Nature, 2003; 425(6961): 912-3.

Bredfeldt, CE Ringach, DL Dynamics of spatial frequency tuning in macaque V1 The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2002; 22(5): 1976-84.

Bredfeldt C, Ringach D Dynamics of spatial frequency tuning of macaque LGN, J Vis, 2002; 2(7): 219a.

Nykamp, DQ Ringach, DL Full identification of a linear-nonlinear system via cross-correlation analysis Journal of vision [electronic resource]. , 2002; 2(1): 1-11.

Nykamp DQ, Ringach DL. Full identification of a linear-nonlinear system via cross-correlation analysis, J Vis, 2002; 2(1): 1-11.

Dorn JD, Ringach DL Long-range interactions in macaque primary visual cortex, J Vis, 2002; 2(7): 108a.

Mechler F, Ringach DL On the classification of simple and complex cells, Vis Res, 2002; 42(8): 1017-33.

Mechler F, Ringach DL. On the classification of simple and complex cells, Vision Res, 2002; 42(8): 1017-33.

Ringach, DL Shapley, RM Hawken, MJ Orientation selectivity in macaque V1: diversity and laminar dependence The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2002; 22(13): 5639-51.

Mechler F, Ringach jDL Re-evaluating the dichotomy between simple and complex cells in primary visual cortex (V1), J Vis, 2002; 2(7): 124a.

Ringach, DL Hawken, MJ Shapley, R Receptive field structure of neurons in monkey primary visual cortex revealed by stimulation with natural image sequences Journal of vision [electronic resource]. , 2002; 2(1): 12-24.

Ringach DL, Hawken MJ, Shapley R. Receptive field structure of neurons in monkey primary visual cortex revealed by stimulation with natural image sequences, J Vis, 2002; 2(1): 12-24.

Ringach, DL Spatial structure and symmetry of simple-cell receptive fields in macaque primary visual cortex Journal of neurophysiology. , 2002; 88(1): 455-63.

Ringach, DL Bredfeldt, CE Shapley, RM Hawken, MJ Suppression of neural responses to nonoptimal stimuli correlates with tuning selectivity in macaque V1 Journal of neurophysiology. , 2002; 87(2): 1018-27.

Hqwken MJ, Shapley RM, Ringach DL, Sceniak MP, Johnson EN, Mareschal I, Henrie JA Contrast gain as a function of the temporal frequency of macaque V1 neurons, Invest Ophthal & Vis Sci, 2001; 42(4): 3898, Suppl. S.

Hawken MJ, Shapley R, Sceniak MP, Ringach DL, Johnson EN Contrast gain, area summation and temporal tuning in primate visual cortex, Vision and Attention, 2001; .

Pugh, MC Ringach, DL Shapley, R Shelley, MJ Computational modeling of orientation tuning dynamics in monkey primary visual cortex Journal of computational neuroscience. , 2000; 8(2): 143-59.

Ringach DL, Bredfeldt CE, Dorn JD, Spriggs D, Irazoqui-Pastor P Dynamics of spatial frequency selectivity in macaque primary visual cortex, Invest Ophthal & Vis Sci, 2000; 41(4): 1749.

Sceniak, MP Ringach, DL Hawken, MJ Shapley, R Contrast’s effect on spatial summation by macaque V1 neurons Nature neuroscience. , 1999; 2(8): 733-9.

Shapley R, Ringach D Dynamics of Responses in Visual Cortex, The New Cognitive Neurosciences, 1999; . Ringach, DL Tuning of orientation detectors in human vision Vision research. , 1998; 38(7): 963-72.

Ringach, DL Hawken, MJ Shapley, R Dynamics of orientation tuning in macaque primary visual cortex Nature. , 1997; 387(6630): 281-4.

Carandini, M Ringach, DL Predictions of a recurrent model of orientation selectivity Vision research. , 1997; 37(21): 3061-71.

Research

My research program is concerned with the neuronal circuits that control gastrointestinal motility and the mechanisms that govern receptor-mediated responses in the enteric nervous system, the “brain in the gut”, and with chemosensing in the gastrointestinal tract. Currently, the main lines of my research include: (1) trafficking and signaling of G protein-coupled receptors induced by physiological and pathophysiological events with an emphasis on µ opioid receptor, the target of opioid analgesics used for pain control, which mediates opioid bowel syndrome and tolerance, and (2) role of taste signaling molecules in the regulation of gastrointestinal functions and feeding behavior. My group was the first to demonstrate that opioids differing in their ability to induce tolerance also differ in their efficiency to induce µOR trafficking, a process that regulates receptor signaling and function. The findings of ligand-selective and stimulation-dependent µOR internalization in enteric neurons are of importance for understanding the mechanisms underlying intracellular adaptations induced by prolonged activation of µORs, which hamper the use of opioids as analgesics. Furthermore, we have shown that µOR activation exerts a protective effect on acute intestinal inflammation through cytokine and NF-KB modulation. Another focus of my research is on the role of taste signaling molecules as chemosensory receptors in the gut mucosa, which are likely to modulate gut function and food intake through the release of signaling molecules by enteroendocrine cells, with emphasis on bitter taste receptors, a putative side of defense from potentially toxic substances, drugs and pathogens. The recent discovery that taste receptors for sweet and bitter are expressed throughout the body and not only in the tongue has given rise to the concept of a broader role for these receptors beyond “taste”. My lab has shown that taste signaling molecules are expressed by distinct populations of mucosal cells, including enteroendocrine cells, which synthesize peptides affecting motility, secretion, satiety and hunger, and that bitter taste receptors are regulated by feeding and different diets, suggesting they participate in the functional detection of intraluminal content and they serve as regulators of diet-induced responses by detecting changing in the microbiota. Biography The “Brain in the Gut” and Taste Receptors My research program is concerned with the neuronal circuits that control gastrointestinal motility and the mechanisms that govern receptor-mediated responses in the enteric nervous system, the “brain in the gut”, and with chemosensing in the gastrointestinal tract. Currently, the main lines of my research include: (1) trafficking and signaling of G protein-coupled receptors induced by physiological and pathophysiological events with an emphasis on µ opioid receptor, the target of opioid analgesics used for pain control, which mediates opioid bowel syndrome and tolerance, and (2) role of taste signaling molecules in the regulation of gastrointestinal functions and feeding behavior. My group was the first to demonstrate that opioids differing in their ability to induce tolerance also differ in their efficiency to induce µOR trafficking, a process that regulates receptor signaling and function. The findings of ligand-selective and stimulation-dependent µOR internalization in enteric neurons are of importance for understanding the mechanisms underlying intracellular adaptations induced by prolonged activation of µORs, which hamper the use of opioids as analgesics. Furthermore, we have shown that µOR activation exerts a protective effect on acute intestinal inflammation through cytokine and NF-KB modulation. Another focus of my research is on the role of taste signaling molecules as chemosensory receptors in the gut mucosa, which are likely to modulate gut function and food intake through the release of signaling molecules by enteroendocrine cells, with emphasis on bitter taste receptors, a putative side of defense from potentially toxic substances, drugs and pathogens. The recent discovery that taste receptors for sweet and bitter are expressed throughout the body and not only in the tongue has given rise to the concept of a broader role for these receptors beyond “taste”. My lab has shown that taste signaling molecules are expressed by distinct populations of mucosal cells, including enteroendocrine cells, which synthesize peptides affecting motility, secretion, satiety and hunger, and that bitter taste receptors are regulated by feeding and different diets, suggesting they participate in the functional detection of intraluminal content and they serve as regulators of diet-induced responses by detecting changes in the microbiota.

Publications

Anselmi Laura, Huynh Jennifer, Vegezzi Gaia, Sternini Catia Effects of methylnaltrexone on guinea pig gastrointestinal motility. Naunyn-Schmiedeberg’s archives of pharmacology. 2013; 386(4): 279-86.

Latorre Rocco, Mazzoni Maurizio, De Giorgio Roberto, Vallorani Claudia, Bonaldo Alessio, Gatta Pier Paolo, Corinaldesi Roberto, Ruggeri Eugenio, Bernardini Chiara, Chiocchetti Roberto, Sternini Catia, Clavenzani Paolo Enteroendocrine profile of alpha-transducin immunoreactive cells in the gastrointestinal tract of the European sea bass (Dicentrarchus labrax). Fish physiology and biochemistry. 2013; 145(3): .

Mazzoni Maurizio, De Giorgio Roberto, Latorre Rocco, Vallorani Claudia, Bosi Paolo, Trevisi Paolo, Barbara Giovanni, Stanghellini Vincenzo, Corinaldesi Roberto, Forni Monica, Faussone-Pellegrini Maria S, Sternini Catia, Clavenzani Paolo Expression and regulation of alpha-transducin in the pig gastrointestinal tract. Journal of cellular and molecular medicine. 2013; 17(4): 466-74.

Sternini Catia In search of a role for carbonation: is this a good or bad taste?. Gastroenterology. 2013; 145(3): 500-3. Anselmi Laura, Jaramillo Ingrid, Palacios Michelle, Huynh Jennifer, Sternini Catia Ligand-induced mu opioid receptor internalization in enteric neurons following chronic treatment with the opiate fentanyl. Journal of neuroscience research. 2013; 91(6): 854-60.

Saccani Francesca, Anselmi Laura, Jaramillo Ingrid, Bertoni Simona, Barocelli Elisabetta, Sternini Catia Protective role of mu opioid receptor activation in intestinal inflammation induced by mesenteric ischemia/reperfusion in mice. Journal of neuroscience research. 2012; 90(11): 2146-53.

Patierno Simona, Anselmi Laura, Jaramillo Ingrid, Scott David, Garcia Rachel, Sternini Catia Morphine induces mu opioid receptor endocytosis in guinea pig enteric neurons following prolonged receptor activation. Gastroenterology. 2011; 140(2): 618-26.

Young Steven H, Rey Osvaldo, Sternini Catia, Rozengurt Enrique Amino acid sensing by enteroendocrine STC-1 cells: role of the Na+-coupled neutral amino acid transporter 2. American journal of physiology. Cell physiology. 2010; 298(6): C1401-13.

Hao Shuzhen, Dulake Michelle, Espero Elvis, Sternini Catia, Raybould Helen E, Rinaman Linda Central Fos expression and conditioned flavor avoidance in rats following intragastric administration of bitter taste receptor ligands. American journal of physiology. Regulatory, integrative and comparative physiology. 2009; 296(3): R528-36.

Anselmi Laura, Stella Salvatore L, Brecha Nicholas C, Sternini Catia Galanin inhibition of voltage-dependent Ca(2+) influx in rat cultured myenteric neurons is mediated by galanin receptor 1. Journal of neuroscience research. 2009; 87(5): 1107-14.

Sternini Catia, Anselmi Laura, Rozengurt Enrique Enteroendocrine cells: a site of ‘taste’ in gastrointestinal chemosensing. Current opinion in endocrinology, diabetes, and obesity. 2008; 15(1): 73-8.

Hao Shuzhen, Sternini Catia, Raybould Helen E Role of CCK1 and Y2 receptors in activation of hindbrain neurons induced by intragastric administration of bitter taste receptor ligands. American journal of physiology. Regulatory, integrative and comparative physiology. 2008; 294(1): R33-8.

Kimura T, Koya RC, Anselmi L, Sternini C, Wang HJ, Comin-Anduix B, Prins RM, Faure-Kumar E, Rozengurt N, Cui Y, Kasahara N, Stripecke R. Lentiviral Vectors with CMV or MHCII Promoters Administered In Vivo: Immune Reactivity Versus Persistence of Expression. Mol Ther 2007; 15(7): 1390-9.

Dellabianca A, Sacchi M, Anselmi L, De Amici E, Cervio E, Agazzi A, Tonini S, Sternini C, Tonini M, Candura SM. Role of carbon monoxide in electrically induced non-adrenergic, non-cholinergic relaxations in the guinea-pig isolated whole trachea. Br J Pharmacol 2007; 150(2): 220-6.

Rozengurt Enrique, Sternini Catia Taste receptor signaling in the mammalian gut. Current opinion in pharmacology. 2007; 7(6): 557-62. Sternini C. Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing. Am J Physiol Gastrointest LIver Physiol 2007; 292(2): G457-61.

Sternini Catia Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing. American journal of physiology. Gastrointestinal and liver physiology. 2007; 292(2): G457-61.

Rozengurt N, Wu SV, Chen MC, Huang C, Sternini C, Rozengurt E. Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. Am J Physiol Gastrointest Liver Physiol 2006; 291(5): G792-802.

Rozengurt Nora, Wu S Vincent, Chen Monica C, Huang Carlos, Sternini Catia, Rozengurt Enrique Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. American journal of physiology. Gastrointestinal and liver physiology. 2006; 291(5): G792-802.

Freeman SL, Glatzle J, Robin CS, Valdellon M, Sternini C, Sharp JW, Raybould HE. Ligand-induced 5-HT3 receptor internalization in enteric neurons in rat ileum. Gastroenterology 2006; 131(1): 97-107.

Freeman Samara L, Glatzle Jorg, Robin Carla S, Valdellon Melissa, Sternini Catia, Sharp James W, Raybould Helen E Ligand-induced 5-HT3 receptor internalization in enteric neurons in rat ileum. Gastroenterology. 2006; 131(1): 97-107.

Cattaruzzza F, Cenac N, Barocelli E, Impicciatore M, Hyun E, Vergnolle N, Sternini C. Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents. Am J Pathol 2006; 169(1): 177-88.

Cattaruzza Fiore, Cenac Nicolas, Barocelli Elisabetta, Impicciatore Mariannina, Hyun Eric, Vergnolle Nathalie, Sternini Catia Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents. The American journal of pathology. 2006; 169(1): 177-88.

Bradesi Sylvie, Kokkotou Efi, Simeonidis Simos, Patierno Simona, Ennes Helena S, Mittal Yash, McRoberts James A, Ohning Gordon, McLean Peter, Marvizon Juan Carlos, Sternini Catia, Pothoulakis Charalabos, Mayer Emeran A The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats. Gastroenterology. 2006; 130(6): 1729-42.

Tonini M, Vicini R, Cervio E, De Ponti F, De Giorgio R, Barbara G, Stanghellini V, Dellabianca A, Sternini C. 5-HT7 receptors modulate peristalsis and accommodation in the guinea pig ileum. Gastroenterology 2005; 129(5): 1557-66.

Tonini Marcello, Vicini Riccardo, Cervio Elisabetta, De Ponti Fabrizio, De Giorgio Roberto, Barbara Giovanni, Stanghellini Vincenzo, Dellabianca Antonio, Sternini Catia 5-HT7 receptors modulate peristalsis and accommodation in the guinea pig ileum. Gastroenterology. 2005; 129(5): 1557-66.

Calcina F, Barocelli E, Bertoni S, Furukawa O, Kaunitz J, Impicciatore M, Sternini C. Effect of N-methyl-d-aspartate receptor blockade on neuronal plasticity and gastrointestinal transit delay induced by ischemia/reperfusion in rats. Neuroscience 2005; 134(1): 39-49.

Anselmi L, Lakhter A, Hirano AA, Tonini M, Sternini C. Expression of galanin receptor messenger RNAs in different regions of the rat gastrointestinal tract. Peptides 2005; 26(5): 815-9.

Anselmi Laura, Lakhter Alexander, Hirano Arlene A, Tonini Marcello, Sternini Catia Expression of galanin receptor messenger RNAs in different regions of the rat gastrointestinal tract. Peptides. 2005; 26(5): 815-9.

Anselmi L, Stella SL Jr, Lakhter A, Hirano A, Tonini M, Sternini C. Galanin receptors in the rat gastrointestinal tract. Neuropeptides 2005; 39(3): 349-52.

Anselmi Laura, Stella Salvatore L, Lakhter Alexander, Hirano Arlene, Tonini Marcello, Sternini Catia Galanin receptors in the rat gastrointestinal tract. Neuropeptides. 2005; 39(3): 349-52.

Anselmi L, Cervio E, Guerrini S, Vicini R, Agazzi A, Dellabianca A, Reeve JR jr, Tonini M, Sternini C. Identification of galanin receptor 1 on excitatory motor neurons in the guinea pig ileum. Neurogastroenterol Motil 2005; 17(2): 273-80.

Cottrell GS, Roosterman D, Marvizon JC, Song B, Wick E, Pikios S, Wong H, Berthelier C, Tang Y, Sternini C, Bunnett NW, Grady EF. Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat. J Comp Neurol 2005; 490(3): 239-55.

Cottrell Graeme S, Roosterman Dirk, Marvizon Juan-Carlos, Song B, Wick Elizabeth, Pikios Stella, Wong Helen, Berthelier Claire, Tang Yat, Sternini Catia, Bunnett Nigel W, Grady Eileen F Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat. The Journal of comparative neurology. 2005; 490(3): 239-55.

Patierno S, Zellalem W, Ho A, Parsons CG, Lloyd KC, Tonini M, Sternini C. N-methyl-D-aspartate receptors mediate endogenous opioid release in enteric neurons after abdominal surgery. Gastroenterology 2005; 128(7): 2009-19.

Patierno Simona, Zellalem Wubanche, Ho Anthony, Parsons Chris G, Lloyd K C Kent, Tonini Marcello, Sternini Catia N-methyl-D-aspartate receptors mediate endogenous opioid release in enteric neurons after abdominal surgery. Gastroenterology. 2005; 128(7): 2009-19.

Lu YC, Sternini C, Rozengurt E, Zhukova E. Release of transgenic human insulin from gastric g cells: a novel approach for the amelioration of diabetes. Endocrinology 2005; 146(6): 2610-9.

Lu Yu-Chun, Sternini Catia, Rozengurt Enrique, Zhukova Elena Release of transgenic human insulin from gastric g cells: a novel approach for the amelioration of diabetes. Endocrinology. 2005; 146(6): 2610-9.

Patierno, S Raybould, HE Sternini, C Abdominal surgery induces mu opioid receptor endocytosis in enteric neurons of the guinea-pig ileum. Neuroscience. . 2004; 123(1): 101-9.

Guerrini S, Raybould HE, Anselmi L, Agazzi A, Cervio E, Reeve JR Jr, Tonini M, Sternini C. Role of galanin receptor 1 in gastric motility in rat. Neurogastroenterol Motil 2004; 16(4): 429-38.

Sternini C, Anselmi L, Guerrini S, Cervio E, Pham T, Balestra B, Vicini R, Baiardi P, D’agostino GL, Tonini M. Role of galanin receptor 1 in peristaltic activity in the guinea pig ileum. Neuroscience 2004; 125(1): 103-12.

Sternini C, Patierno S, Selmer IS, Kirchgessner A. The opioid system in the gastrointestinal tract. Neurogastroenterol Motil 2004; 16(Suppl 2): 3-16.

Raybould Helen E, Glatzle Jorg, Robin Carla, Meyer James H, Phan Thomas, Wong Helen, Sternini Catia Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying. American journal of physiology. Gastrointestinal and liver physiology. 2003; 284(3): G367-72.

Raybould, HE Glatzle, J Robin, C Meyer, JH Phan, T Wong, H Sternini, C Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying. American journal of physiology. Gastrointestinal and liver physiology. 2003; 284(3): G367-72.

Minnis, JG Patierno, S Kohlmeier, SE Brecha, NC Tonini, M Sternini, C Ligand-induced mu opioid receptor endocytosis and recycling in enteric neurons. Neuroscience. . 2003; 119(1): 33-42.

Ho, A Lievore, A Patierno, S Kohlmeier, SE Tonini, M Sternini, C Neurochemically distinct classes of myenteric neurons express the mu-opioid receptor in the guinea pig ileum. The Journal of comparative neurology. . 2003; 458(4): 404-11.

Ho Anthony, Lievore Annarita, Patierno Simona, Kohlmeier Sean E, Tonini Marcello, Sternini Catia Neurochemically distinct classes of myenteric neurons express the mu-opioid receptor in the guinea pig ileum. The Journal of comparative neurology. 2003; 458(4): 404-11.

Pham, T Guerrini, S Wong, H Reeve, J Sternini, C Distribution of galanin receptor 1 immunoreactivity in the rat stomach and small intestine. The Journal of comparative neurology. . 2002; 450(3): 292-302.

Pham Thomas, Guerrini Stefania, Wong Helen, Reeve Joseph, Sternini Catia Distribution of galanin receptor 1 immunoreactivity in the rat stomach and small intestine. The Journal of comparative neurology. 2002; 450(3): 292-302.

Glatzle, J Sternini, C Robin, C Zittel, TT Wong, H Reeve, JR Raybould, HE Expression of 5-HT3 receptors in the rat gastrointestinal tract. Gastroenterology. . 2002; 123(1): 217-26.

Glatzle Jörg, Sternini Catia, Robin Carla, Zittel Tilman T, Wong Helen, Reeve Joseph R, Raybould Helen E Expression of 5-HT3 receptors in the rat gastrointestinal tract. Gastroenterology. 2002; 123(1): 217-26.

Salvioli Beatrice, Bovara Monica, Barbara Giovanni, De Ponti Fabrizio, Stanghellini Vincenzo, Tonini Marcello, Guerrini Stefania, Cremon Cesare, Degli Esposti Marzia, Koumandou Magdalina, Corinaldesi Roberto, Sternini Catia, De Giorgio Roberto Neurology and neuropathology of the pancreatic innervation. JOP : Journal of the pancreas. 2002; 3(2): 26-33.

Schmidlin, F Dery, O DeFea, KO Slice, L Patierno, S Sternini, C Grady, EF Bunnett, NW Dynamin and Rab5a-dependent trafficking and signaling of the neurokinin 1 receptor. The Journal of biological chemistry. . 2001; 276(27): 25427-37.

Zhukova, E Afshar, A Ko, J Popper, P Pham, T Sternini, C Walsh, JH Expression of the human insulin gene in the gastric G cells of transgenic mice. Transgenic research. . 2001; 10(4): 329-41.

Wong, HC Sternini, C Yang, H Pham, T Walsh, JH Monoclonal antibody to rat galanin: production, characterization, and in vivo immunoneutralization activity. Hybridoma. . 2001; 20(2): 109-15.

Tonini, M Spelta, V De Ponti, F De Giorgio, R D’Agostino, G Stanghellini, V Corinaldesi, R Sternini, C Crema, F Tachykinin-dependent and -independent components of peristalsis in the guinea pig isolated distal colon. Gastroenterology. . 2001; 120(4): 938-45.

Melone, M Brecha, NC Sternini, C Evans, C Conti, F Etorphine increases the number of mu-opioid receptor-positive cells in the cerebral cortex. Neuroscience. . 2000; 100(3): 439-43.

De Giorgio R, Arakawa J, Wetmore CJ, Sternini C Neutrophin-3 and neutrophin receptor immunoreactivity in peptidergic enteric neurons. Peptides 2000; 21: 1421-26.

Sternini, C Brecha, NC Minnis, J D’Agostino, G Balestra, B Fiori, E Tonini, M Role of agonist-dependent receptor internalization in the regulation of mu opioid receptors. Neuroscience. . 2000; 98(2): 233-41.

Tonini, M De Giorgio, R De Ponti, F Sternini, C Spelta, V Dionigi, P Barbara, G Stanghellini, V Corinaldesi, R Role of nitric oxide- and vasoactive intestinal polypeptide-containing neurones in human gastric fundus strip relaxations. British journal of pharmacology. . 2000; 129(1): 12-20.

McConalogue, K Grady, EF Minnis, J Balestra, B Tonini, M Brecha, NC Bunnett, NW Sternini, C Activation and internalization of the mu-opioid receptor by the newly discovered endogenous agonists, endomorphin-1 and endomorphin-2. Neuroscience. . 1999; 90(3): 1051-9.

Sternini C, Wong H, Pham T, De Giorgio R, Miller LJ, Kuntz SM, Reeve JR, Walsh JH, Raybould HE Expression of cholecystokinin A receptors in neurons innvervating the rat stomach and intestine. Gastroenterology 1999; 117: 1136-46.

Lecci A, De Giorgio R, Bartho L, Sternini C, Tramontana M, Corinaldesi R, Giuliani S, Maggi CA Tachykinin NK(1)receptor-mediated inhibitory responses in the guinea pig small intestine. Neuropeptides 1999; 33: 91-97.

Sternini C, Wong H, Wu SV, De Giorgio R, Yang M, Reeve J, Jr., Brecha NC, Walsh JH Somatostatin 2A receptor is expressed by enteric neruons, and by interstitial cells of Cajal and enterochromaffin-like cells. Journal of Comparative Neurology 1997; 386: 396-408.

Sternini, C Spann, M Anton, B Keith, DE Bunnett, NW von Zastrow, M Evans, C Brecha, NC Agonist-selective endocytosis of mu opioid receptor by neurons in vivo. Proceedings of the National Academy of Sciences of the United States of America. . 1996; 93(17): 9241-6.

Sternini, C Su, D Gamp, PD Bunnett, NW Cellular sites of expression of the neurokinin-1 receptor in the rat gastrointestinal tract. The Journal of comparative neurology. . 1995; 358(4): 531-40.

Duraffourd Celine, Kumala Erica, Anselmi Laura, Brecha Nicholas C, Sternini Catia Opioid-induced mitogen-activated protein kinase signaling in rat enteric neurons following chronic morphine treatment. PloS one. 2014; 9(10): e110230.

Vegezzi Gaia, Anselmi Laura, Huynh Jennifer, Barocelli Elisabetta, Rozengurt Enrique, Raybould Helen, Sternini Catia Diet-induced regulation of bitter taste receptor subtypes in the mouse gastrointestinal tract. PloS one. 2014; 9(9): e107732.

Anselmi L, Huynh J, Duraffourd C, Jaramillo I, Vegezzi G, Saccani F, Boschetti E, Brecha N C, De Giorgio R, Sternini C Activation of mu opioid receptors modulates inflammation in acute experimental colitis. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2015; 27(4): 509-23.