Posts classified under: Faculty

Houser

Carolyn Houser, Ph.D.

Research Interest

Neurochemical anatomy, neuronal plasticity and development of the CNS

Publications

Peng Zechun, Zhang Nianhui, Wei Weizheng, Huang Christine S, Cetina Yliana, Otis Thomas S, Houser Carolyn R A reorganized GABAergic circuit in a model of epilepsy: evidence from optogenetic labeling and stimulation of somatostatin interneurons The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(36): 14392-405.

Mathews Paul J, Lee Ka Hung, Peng Zechun, Houser Carolyn R, Otis Thomas S Effects of climbing fiber driven inhibition on Purkinje neuron spiking The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(50): 17988-97.

Houser Carolyn R, Zhang Nianhui, Peng Zechun, Huang Christine S, Cetina Yliana Neuroanatomical clues to altered neuronal activity in epilepsy: from ultrastructure to signaling pathways of dentate granule cells Epilepsia, 2012; 53 Suppl 1(50): 67-77.

Houser Carolyn R, Zhang Nianhui, Peng Zechun, Huang Christine S, Cetina Yliana Neuroanatomical clues to altered neuronal activity in epilepsy: from ultrastructure to signaling pathways of dentate granule cells Epilepsia, 2012; 53 Suppl 1(50): 67-77.

Soussi Rabia, Zhang Nianhui, Tahtakran Siroun, Houser Carolyn R, Esclapez Monique Heterogeneity of the supramammillary-hippocampal pathways: evidence for a unique GABAergic neurotransmitter phenotype and regional differences The European journal of neuroscience, 2010; 32(5): 771-85.

Li Yi, Peng Zechun, Xiao Bo, Houser Carolyn R Activation of ERK by spontaneous seizures in neural progenitors of the dentate gyrus in a mouse model of epilepsy Experimental neurology, 2010; 224(1): 133-45.

Wyeth Megan S, Zhang Nianhui, Mody Istvan, Houser Carolyn R Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(26): 8993-9006.

Heusner CL, Beutler LR, Houser CR, Palmiter RD. Deletion of GAD67 in dopamine receptor-1 expressing cells causes specific motor deficits, Genesis, 2008; 46(7): 357-67.

Houser CR, Huang CS, Peng Z. Dynamic seizure-related changes in extracellular signal-regulated kinase activation in a mouse model of temporal lobe epilepsy, Neuroscience, 2008; .

Glykys J, Peng Z, Chandra D, Homanics GE, Houser CR, Mody I. A new naturally occurring GABA(A) receptor subunit partnership with high sensitivity to ethanol, Nat Neurosci, 2007; 10(1): 40-8.

Zhang N, Wei W, Mody I, Houser CR. Altered localization of GABA(A) receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy, J Neurosci, 2007; 27(28): 7520-31.

Houser CR. Interneurons of the dentate gyrus: An overview of cell types, terminal fields and neurochemical identity, Prog Brain Res, 2007; 163: 217-811.

Liang J, Zhang N, Cagetti E, Houser CR, Olsen RW, Spigelman I. Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors, J Neurosci, 2006; 26(6): 1749-58.

Chandra D, Jia F, Liang J, Peng Z, Suryanarayanan A, Werner DF, Spigelman I, Houser CR, Olsen RW, Harrison NL, Homanics GE. GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol, Proc Natl Acad Sci U S A, 2006; 103(41): 15230-5.

Swartz BE, Houser CR, Tomiyasu U, Walsh GO, DeSalles A, Rich JR, Delgado-Escueta A. Hippocampal cell loss in posttraumatic human epilepsy, Epilepsia, 2006; 47(8): 1373-82.

Farrar C, Houser CR, Clarke S. Activation of the PI3K/Akt signal transduction pathway and increased levels of insulin receptor in protein repair-deficient mice, Aging Cell, 2005; 4(1): 1-12.

Farrar CE, Huang CS, Clarke SG, Houser CR. Increased cell proliferation and granule cell number in the dentate gyrus of protein repair-deficient mice, J Comp Neurol, 2005; 493(4): 527-37.

Peng Z, Houser CR. Temporal patterns of fos expression in the dentate gyrus after spontaneous seizures in a mouse model of temporal lobe epilepsy, J Neurosci, 2005; 25(31): 7210-20.

Peng Z, Huang CS, Stell BM, Mody I, Houser CR. Altered expression of the delta subunit of the GABAA receptor in a mouse model of temporal lobe epilepsy, J Neurosci, 2004; 24(39): 8629-39.

Houser CR, Esclapez M. Downregulation of the alpha5 subunit of the GABA(A) receptor in the pilocarpine model of temporal lobe epilepsy, Hippocampus, 2003; 13(5): 633-45.

Wei W, Zhang N, Peng Z, Houser CR, Mody I. Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus, J Neurosci, 2003; 23(33): 10650-61.

Peng Z, Hauer B, Mihalek RM, Homanics GE, Sieghart W, Olsen RW, Houser CR. GABA(A) receptor changes in delta subunit-deficient mice: altered expression of alpha4 and gamma2 subunits in the forebrain, J Comp Neurol, 2002; 446(2): 179-97.

Houser CR, Esclapez M, Zhang N. GABA neurons of the hippocampal formation: Localization, vulnerability and plasticity, GABA in the Nervous System: The View at Fifty Years, 2000; 337-56.

Dupuy-Davies S, Houser CR. Evidence for changing positions of GABA neurons in the developing rat dentate gyrus Hippocampus, 1999; 9(2): 186-99.

Houser CR. Neuronal loss and synaptic reorganization in temporal lobe epilepsy, Adv Neurol, 1999; 79: 743-61.

Houser, CR, Dupuy, ST, Zhang N. Prominent expression of glutamate decarboxylase during early hippocampal development, Childhood Epilepsies and Brain Development, 1999; pp.13-24.

Zhang N, Houser CR. Ultrastructural localization of dynorphin in the dentate gyrus in human temporal lobe epilepsy: a study of reorganized mossy fiber synapses, J Comp Neurol, 1999; 405(4): 472-90.

Esclapez M, Houser CR. Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy, J Comp Neurol, 1999; 412(3): 488-505.

Dupuy ST, Houser CR. Developmental changes in GABA neurons of the rat dentate gyrus: an in situ hybridization and birthdating study J Comp Neurol, 1997; 389(3): 402-18.

Houser CR, Esclapez, M. Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures Epilepsy Res, 1996; 26(1): 207-18.

Dupuy ST, Houser CR. Prominent expression of two forms of glutamate decarboxylase in the embryonic and early postnatal rat hippocampal formation J Neurosci, 1996; 16(21): 6919-32.

Esclapez, M, Chang D, Houser CR. Subpopulations of GABA neurons in the dentate gyrus express high levels of the alpha1 subunit of the GABA-A receptor, Hippocampus, 1996; 6: 225-238.

Esclapez M, Houser CR. Somatostatin neurons are a subpopulation of GABA neurons in the rat dentate gyrus: Evidence from co-localization of pre-prosomatostatin and glutamate decarboxylase mRNAs, Neuroscience, 1995; 64: 339-355.

Houser CR, Esclapez M. Localization of mRNAs encoding two forms of glutamic acid decarboxylase in the rat hippocampal formation Hippocampus, 1994; 4(5): 530-45.

Esclapez M, Tillakaratne NJ, Kaufman DL, Tobin AJ, Houser CR. Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms J Neurosci, 1994; 14(3 Pt 2): 1834-55.

Obenaus A, Esclapez M, Houser CR. Loss of glutamate decarboxylase mRNA-containing neurons in the rat dentate gyrus following pilocarpine-induced seizures J Neurosci, 1993; 13(10): 4470-85.

Esclapez M, Tillakaratne NJ, Tobin AJ, Houser CR. Comparative localization of mRNAs encoding two forms of glutamic acid decarboxylase with nonradioactive in situ hybridization methods J Comp Neurol, 1993; 331(3): 339-62.

Houser CR GABA neurons in seizure disorders: A review of immunocytochemical studies, Neurochem Res, 1991; 16: 295-308.

Kafman DL, Houser CR, Tocin AJ Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions, J Neurochem, 1991; 56: 720-723.

Houser, CR Granule cell dispersion in the dentate gyrus of humans with temporal lobe epilepsy, Brain Res, 1990; 535: 195-204.

Houser CR, Miyashiro JE, Swartz BE, Walsh GO, Rich JR, Delgado-Escueta AV. Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy J Neurosci, 1990; 10(1): 267-82.

Sotiris Masmanidis, Ph.D.

Sotiris Masmanidis, Ph.D.

Research Interests

Effects of addiction and depression on brain reward circuitry

Cell-to-cell signaling regime in the basal ganglia and limbic system

Adaptation to rewarding experiences and associated cues

Recent Papers

Alivisatos A.P., Andrews A.M., Boyden E.S., Chun M., Church G.M., Deisseroth K., Donoghue J.P., Fraser S.E., Lippincott-Schwartz J., Looger L.L., Masmanidis S., McEuen P.L., Nurmikko A.V., Park H., Peterka D.S., Reid C., Roukes M.L., Scherer A., Schnitzer M., Sejnowski T.J., Shepard K.L., Tsao D., Turrigiano G., Weiss P.S., Xu C., Yuste R., Zhuang X. “Nanotools for neuroscience and brain activity mapping.” ACS Nano. 2013 Mar 26;7(3):1850-66.

Scott K.M., Du J., Lester H.A., Masmanidis S.C. “Variability of acute extracellular action potential measurements with multisite silicon probes.” J Neurosci Methods. 2012 Oct 15;211(1):22-30.

Lee S.H., Kwan A.C., Zhang S., Phoumthipphavong V., Flannery J.G., Masmanidis S.C., Taniguchi H., Huang Z.J., Zhang F., Boyden E.S., Deisseroth K., Dan Y. “Activation of specific interneurons improves V1 feature selectivity and visual perception.” Nature. 2012 Aug 16;488(7411):379-83.

Karabalin R.B., Lifshitz R., Cross M.C., Matheny M.H., Masmanidis S.C., Roukes M.L. “Signal amplification by sensitive control of bifurcation topology.” Physical Review Letters. 2011;106: 094102. Du J., Blanche T.J., Harrison R.R., Lester H.A., Masmanidis S.C. “Multiplexed, high density electrophysiology with nanofabricated neural probes.” PLoS One. 2011;6(1):e26204.

Sadek A.S., Karabalin R.B., Du J., Roukes M.L., Koch C., Masmanidis S.C. “Wiring nanoscale biosensors with piezoelectric nanomechanical resonators.” Nano Lett. 2010 May 12;10(5):1769-73.

Karabalin R.B., Masmanidis S.C., Roukes M.L. “Efficient parametric amplification with high and very high frequency piezoelectric nanoelectromechanical systems.” Applied Physics Letters. 2010;97: 183101.

Du J., Roukes M.L., Masmanidis S.C. “Dual-side and three-dimensional microelectrode arrays fabricated from ultra-thin silicon substrates.” J. Micromechanics & Microengineering, 19: 075008 (2009).

Du J., Riedel-Kruse I.H., Nawroth J.C., Roukes M.L., Laurent G., Masmanidis S.C. “High-resolution three-dimensional extracellular recording of neuronal activity with microfabricated electrode arrays.” J Neurophysiol. 2009 Mar;101(3):1671-8.

Masmanidis S.C., Karabalin R.B., De Vlaminck I., Borghs G., Freeman M.R., Roukes M.L. “Multifunctional nanomechanical systems via tunably coupled piezoelectric actuation.” Science. 2007 Aug 10;317(5839):780-3.

Jeffrey Donlea

Jeffrey Donlea, Ph.D.

Sleep is universally conserved across animal species, and continuous sleep loss can kill as rapidly as starvation. The basic functions of sleep, however, are not known. Sleep loss harms systems throughout the body, but the brain is especially sensitive to prolonged waking, and cognitive deficits are among the first consequences of sleep loss. Because the only way to recover from these deficits is to regain lost sleep, sleep must benefit the brain. We are unable to directly examine the molecular functions of sleep in the human brain, but because the consequences of sleep loss are shared between humans and smaller model systems, such as the fruit fly, it is likely that the basic functions of sleep have also been shared across evolution. The simplicity of the fly, along with the wide array of available genetic tools, provide an optimal model to study sleep function and regulation.

Dr. Donlea joined the Department of Neurobiology in the David Geffen School of Medicine as an Assistant Professor in 2016. He previously studied the regulation and function of sleep as a PhD student at Washington University in St. Louis in Paul Shaw’s lab and as a postdoc at the University of Oxford in Gero Miesenböck’s lab. During this work, he identified a small population of ~25 neurons in the fly brain that can be acutely activated to induce sleep on-demand. These neurons act as a sleep homeostat in the brain that works under a similar principle as the thermostat in your home – just as a thermostat turns on the furnace when the temperature is too cold, the sleep homeostat makes flies sleep when they have been awake for too long. Projects in the lab will examine how the sleep homeostat can detect when the brain needs to sleep, and how promoting sleep can enhance cognitive processes, including memory formation.

Jack L. Feldman Ph.D.

Jack L. Feldman Ph.D.

Academic Titles/Accomplishments/Affiliations:

Member, Brain Research Institute
Molecular, Cellular & Integrative Physiology GPB Home Area
Neuroscience GPB Home Area

Research interest:

Research Interests
All meaningful actions of the brain result from the orchestrated activity of many neurons. A central problem confronting neuroscientists is to understand how molecular, synaptic, and cellular properties of individual neurons in densely interconnected networks result in behaviors ranging from hitting a baseball, playing the piano, reading or writing a book, taking an exam, regulating blood pressure or reproduction, or doing research. We have developed a model system that enables us to perform unique studies that directly address this problem. We investigate the neural basis for respiration in the isolated neonate rat brainstem, a preparation that offers simultaneous access to cellular, synaptic and network properties. In this preparation, the circuitry mediating respiration has been localized in a discrete region of brainstem, which can be isolated in a 300 m m thick slice. Using the slice, sophisticated techniques are used to characterize the cellular and synaptic properties of neurons involved in respiration, while at the same time characterizing their interactions at the network level, and recording motor output. Exploiting this preparation, we intend to understand how homeostatically regulated breathing movements occur, and in course, principles of integrative organization in the nervous system. We use whole-cell patch-clamp recording techniques to determine cellular and synaptic properties, including the pharmacology of identified synaptic interactions. We are presently testing our hypothesis that pacemaker neurons underlie the generation of respiratory rhythm. We have several projects looking at general mechanisms underlying the control of neuronal excitability (in functionally identified cells). In particular, we are interested in the interaction among amino acid, amine and peptide neurotransmitters. We have initiated a major program in molecular neurobiology to determine the interesting and unique molecules associated with identified cells in this network; presently, we are developing RT-PCR and mRNA differential display for this purpose. We are also interested in modeling, for which we have excellent computer facilities.

PUBLICATIONS

Kam Kaiwen, Worrell Jason W, Janczewski Wiktor A, Cui Yan, Feldman Jack L   Distinct inspiratory rhythm and pattern generating mechanisms in the preBötzinger complex The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(22): 9235-45.Kam Kaiwen, Worrell Jason W, Ventalon Cathie, Emiliani Valentina, Feldman Jack L   Emergence of population bursts from simultaneous activation of small subsets of preBötzinger complex inspiratory neurons The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(8): 3332-8.Janczewski Wiktor A, Tashima Alexis, Hsu Paul, Cui Yan, Feldman Jack L   Role of inhibition in respiratory pattern generation The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(13): 5454-65.Babiec Walter E, Faull Kym F, Feldman Jack L   Cyclothiazide-induced persistent increase in respiratory-related activity in vitro The Journal of physiology, 2012; 590(Pt 19): 4897-915.Shao Xuesi M, Xu Bin, Liang Jing, Xie Xinmin Simon, Zhu Yifang, Feldman Jack L   Nicotine Delivery to Rats via Lung Alveolar Region-Targeted Aerosol Technology Produces Blood Pharmacokinetics Resembling Human Smoking Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2012; .Tan Wenbin, Sherman David, Turesson Jenny, Shao Xuesi M, Janczewski Wiktor A, Feldman Jack L   Reelin demarcates a subset of pre-Bötzinger complex neurons in adult rat J. Comp. Neurol, 2012; 520(3): 606-19.Feldman Jack L, Del Negro Christopher A, Gray Paul A   Understanding the Rhythm of Breathing: So Near, Yet So Far Annual review of physiology, 2012; .Pagliardini Silvia, Janczewski Wiktor A, Tan Wenbin, Dickson Clayton T, Deisseroth Karl, Feldman Jack L   Active expiration induced by excitation of ventral medulla in adult anesthetized rats J. Neurosci, 2011; 31(8): 2895-905.Feldman Jack L   Chapter 14–looking forward to breathing Prog. Brain. Res, 2011; 188(8): 213-8.Morgado-Valle Consuelo, Baca Serapio M, Feldman Jack L   Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouse J. Neurosci, 2010; 30(10): 3634-9.Tan Wenbin, Pagliardini Silvia, Yang Paul, Janczewski Wiktor A, Feldman Jack L   Projections of preBötzinger complex neurons in adult rats J. Comp. Neurol, 2010; 518(10): 1862-78.Saywell Shane A, Babiec Walter E, Neverova Natalia V, Feldman Jack L   Protein kinase G-dependent mechanisms modulate hypoglossal motoneuronal excitability and long-term facilitation J. Physiol, 2010; 588(Pt 22): 4431-9.Schwab David J, Bruinsma Robijn F, Feldman Jack L, Levine Alex J   Rhythmogenic neuronal networks, emergent leaders, and k-cores Phys. Rev. E, 2010; 82(5 Pt 1): 051911.Del Negro Christopher A, Hayes John A, Pace Ryland W, Brush Benjamin R, Teruyama Ryoichi, Feldman Jack L   Synaptically activated burst-generating conductances may underlie a group-pacemaker mechanism for respiratory rhythm generation in mammals Prog. Brain. Res, 2010; 187(10): 111-36.Del Negro CA, KK, Hayes JA, Feldman JL   Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro J. Physiol, 2009; 587(Pt 6): 1217-31.
DownloadShao Xuesi M, Feldman Jack L   Central cholinergic regulation of respiration: nicotinic receptors Acta pharmacologica Sinica, 2009; 30(6): 761-70.Feldman JL, Kam KK, Janczewski WA   Practice makes perfect, even for breathing Nature Neuroscience, 2009; 12(8): 961-3.
DownloadShao XM, Tan W, Xiu J, Puskar N, Fonck C, Lester HA, Feldman JL   Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm, J Neurosci, 2008; 28(2): 519-28.
DownloadShao Xuesi M, Tan Wenbin, Xiu Joanne, Puskar Nyssa, Fonck Carlos, Lester Henry A, Feldman Jack L   Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008; 28(2): 519-28.Feldman, JL, McCrimmon DR   Neural Control of Breathing, Fundamental Neuroscience, 3rd Edition, 2008; .Tan W, Janczewski WA, Yang Pl, Shao XM, Callaway EM, Feldman JL   Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat Nature Neuroscience, 2008; 11(5): 538-40.
DownloadMorgado-Valle Consuelo, Beltran-Parrazal Luis, DiFranco Marino, Vergara Julio L, Feldman Jack L   Somatic Ca2+ transients do not contribute to inspiratory drive in preBötzinger Complex neurons The Journal of physiology, 2008; 586(Pt 18): 4531-40.McKay LC, Feldman JL   Unilateral ablation of pre-Botzinger complex disrupts breathing during sleep but not wakefulness American Journal of Respiratory and Critical Care Medicine, 2008; 178(1): 89-95.
DownloadShao XM, Feldman JL.   Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLC, J Neurosci Methods, 2007; 160(2): 256-63.Shao Xuesi M, Feldman Jack L   Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLC Journal of neuroscience methods, 2007; 160(2): 256-63.Neverova NV, Saywell SA, Nashold LJ, Mitchell GS, Feldman JL.   Episodic stimulation of alpha 1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability, J Neurosci, 2007; 27(16): 4435-42.Neverova Natalia V, Saywell Shane A, Nashold Lisa J, Mitchell Gordon S, Feldman Jack L   Episodic stimulation of alpha1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(16): 4435-42.Pace RW, Mackay DD, Feldman JL, Del Negro CA   Inspiratory bursts in the preBotzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice, J Physiol, 2007; 582(Pt 1): 113-25.
DownloadPace Ryland W, Mackay Devin D, Feldman Jack L, Del Negro Christopher A   Inspiratory bursts in the preBötzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice The Journal of physiology, 2007; 582(Pt 1): 113-25.Shao XM, Feldman JL.   Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials, J Neurosci Methods, 2007; 159(1): 108-15.Shao Xuesi M, Feldman Jack L   Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials Journal of neuroscience methods, 2007; 159(1): 108-15.Morgado-Valle C, Feldman JL   NMDA receptors in preBotzinger complex neurons can drive respiratory rhythm independent of AMPA receptors, J Physiol, 2007; 582(Pt 1): 359-68.
DownloadMorgado-Valle C, Feldman JL   NMDA receptors in preBotzinger complex neurons can drive respiratory rhythm independent of AMPA receptors The Journal of physiology, 2007; 582(Pt 1): 359-68.
DownloadPace RW, Mackay DD, Feldman JL, Del Negro CA.   Role of persistent sodium current in mouse preBotzinger Complex neurons and respiratory rhythm generation, J Physiol, 2007; 580(Pt 2): 485-96.
DownloadPace Ryland W, Mackay Devin D, Feldman Jack L, Del Negro Christopher A   Role of persistent sodium current in mouse preBötzinger Complex neurons and respiratory rhythm generation The Journal of physiology, 2007; 580(Pt. 2): 485-96.Janczewski WA, Feldman JL   Distinct rhythm generators for inspiration and expiration in the juvenile rat J. Physiol, 2006; 570: 407-420.
DownloadJanczewski WA, Feldman JL.   Distinct rhythm generators for inspiration and expiration in the juvenile rat, J Physiol, 2006; 570(Pt 2): 407-20.Janczewski Wiktor A, Feldman Jack L   Distinct rhythm generators for inspiration and expiration in the juvenile rat The Journal of physiology, 2006; 570(Pt 2): 407-20.Feldman JL, Del Negro CA   Looking for inspiration: new perspectives on respiratory rhythm, Nature Reviews Neuroscience, 2006; 7(3): 232-42.
DownloadFeldman Jack L, Del Negro Christopher A   Looking for inspiration: new perspectives on respiratory rhythm Nature reviews. Neuroscience, 2006; 7(3): 232-42.Janczewski WA, Feldman JL.   Novel data supporting the two respiratory rhythm oscillator hypothesis. Focus on “respiratory-related rhythmic activity in the rostral medulla of newborn rats”, J Neurophysiol, 2006; 96(1): 1-2.Janczewski Wiktor A, Feldman Jack L   Novel data supporting the two respiratory rhythm oscillator hypothesis. Focus on “respiration-related rhythmic activity in the rostral medulla of newborn rats” Journal of neurophysiology, 2006; 96(1): 1-2.Feldman JL, Janczewski WA.   Point: Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBotC is the primary site of respiratroy rhythm generation in the mammal, J Appl Physiol, 2006; 100(6): 2096-7.Feldman Jack L, Janczewski Wiktor A   Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBötC is the primary site of respiratory rhythm generation in the mammal Journal of applied physiology (Bethesda, Md. : 1985), 2006; 100(6): 2096-7; discussion 2097-8, 2103-8.Feldman JL, Janczewski WA.   The Last Word: Point: Counterpoint authors respond to commentaries on “the parafacial respiratory group (pFRG)/ pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal”, J Appl Physiol, 2006; 101(2): 689.Feldman Jack L, Janczewski Wiktor A   The Last Word: Point:Counterpoint authors respond to commentaries on “the parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal” Journal of applied physiology (Bethesda, Md. : 1985), 2006; 101(2): 689.Shao XM, Feldman JL.   Cholinergic neurotransmission in the preBotzinger Complex modulates excitability of inspiratory neurons and regulates respiratory rhythm, Neuroscience, 2005; 130(4): 1069-81.Feldman JL, Neverova NV, Saywell SA.   Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades, Respir Physiol Neurobiol, 2005; 147(2-3): 131-43.Feldman Jack L, Neverova Natalia V, Saywell Shane A   Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades Respiratory physiology & neurobiology, 2005; 147(2-3): 131-43.McKay LC, Janczewski WA, Feldman JL   Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons Nature Neuroscience, 2005; 8(9): 1142-1144.
DownloadMcKay LC, Janczewski WA, Feldman JL   Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons Nature Neuroscience, 2005; 8(9): 1142-4.
DownloadDel Negro CA, Morgado-Valle C, Hayes JA, Mackay DD, Pace RW, Crowder EA, Feldman JL.   Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation, J Neurosci, 2005; 25(2): 446-53.Del Negro CA, Morgado-Valle C, Hayes JA, Mackay DD, Pace RW, Crowder EA, Feldman JL   Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation J. Neurosci, 2005; 25(2): 446-53.
DownloadDel Negro Christopher A, Morgado-Valle Consuelo, Hayes John A, Mackay Devin D, Pace Ryland W, Crowder Erin A, Feldman Jack L   Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005; 25(2): 446-53.Mellen Nicholas M, Roham Maryam, Feldman Jack L   Afferent modulation of neonatal rat respiratory rhythm in vitro: cellular and synaptic mechanisms The Journal of physiology, 2004; 556(Pt 3): 859-74.Saywell, SA Feldman, JL   Dynamic interactions of excitatory and inhibitory inputs in hypoglossal motoneurones: respiratory phasing and modulation by PKA The Journal of physiology. , 2004; 554(Pt 3): 879-89.
DownloadMcKay Leanne C, Janczewski Wiktor A, Feldman Jack L   Episodic hypoxia evokes long-term facilitation of genioglossus muscle activity in neonatal rats The Journal of physiology, 2004; 557(Pt 1): 13-8.Feldman JL, Janczewski WA.   Slip of the tongue, Am J Respir Crit Care Med, 2004; 170(6): 581-2.Feldman Jack L, Janczewski Wiktor A   Slip of the tongue American journal of respiratory and critical care medicine, 2004; 170(6): 581-2.Bocchiaro CM, Feldman JL   Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons PNAS, 2004; 101(12): 4292-5.
DownloadBocchiaro Christopher M, Feldman Jack L   Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons Proceedings of the National Academy of Sciences of the United States of America, 2004; 101(12): 4292-5.Feldman JL, Mitchell GS, Nattie EE   Breathing: rhythmicity, plasticity, chemosensitivity Annual Review of Neuroscience, 2003; 26: 239-66.
DownloadBocchiaro CM, Saywell SA, Feldman JL   Dynamic modulation of inspiratory drive currents by protein kinase A and protein phosphatases in functionally active motoneurons J. Neurosci, 2003; 23(4): 1099-103.
DownloadShao XM, Ge Q, Feldman JL   Modulation of AMPA receptors by cAMP-dependent protein kinase in preBotzinger complex inspiratory neurons regulates respiratory rhythm in the rat, J Physiol, 2003; 545(Pt 2): 543-53.Mellen NM, Janczewski WA, Bocchiaro CM, Feldman, JL   Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation Neuron, 2003; 37(5): 821-6.
DownloadParkis, MA Feldman, JL Robinson, DM Funk, GD   Oscillations in endogenous inputs to neurons affect excitability and signal processing The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2003; 23(22): 8152-8.Mellen, NM Milsom, WK Feldman, JL   Hypothermia and recovery from respiratory arrest in a neonatal rat in vitro brain stem preparation American journal of physiology. Regulatory, integrative and comparative physiology. , 2002; 282(2): R484-91.Chamberlin, NL Bocchiaro, CM Greene, RW Feldman, JL   Nicotinic excitation of rat hypoglossal motoneurons Neuroscience. , 2002; 115(3): 861-70.Janczewski WA, Onimaru H, Homma I, Feldman JL   Opioid-resistant respiratory pathway from the preinspiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn rat J. Physiol, 2002; 545(Pt 3): 1017-26.
DownloadAlheid, GF Gray, PA Jiang, MC Feldman, JL McCrimmon, DR   Parvalbumin in respiratory neurons of the ventrolateral medulla of the adult rat Journal of neurocytology. , 2002; 31(8-9): 693-717.Shao XM, Feldman JL   Pharmacology of nicotinic receptors in preBotzinger complex that mediate modulation of respiratory pattern, J Neurophysiol, 2002; 88(4): 1851-8.Del Negro CA, Morgado-Valle C, Feldman JL   Respiratory rhythm: an emergent network property? Neuron, 2002; 34(5): 821-30.
DownloadGray PA, Janczewski WA, Mellen N, McCrimmon DR, Feldman JL   Normal breathing requires preBotzinger Complex neurokinin-1 receptor expressing neurons, Nature Neuroscience, 2001; 4(9): 927-930.
DownloadMellen, NM Feldman, JL   Phasic vagal sensory feedback transforms respiratory neuron activity in vitro The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2001; 21(18): 7363-71.Lai J, Shao XM, Pan RW, Dy E, Huang CH, Feldman JL   RT-PCR reveals muscarinic acetylcholine receptor mRNA in the pre-Botzinger complex, Am J Physiol Lung Cell Mol Physiol, 2001; 281(6): L1420-4.Rekling JC, Funk GD, Bayliss DA, Dong XW, Feldman JL   Synaptic control of motoneuronal excitability Physiological Reviews , 2000; 80(2): 767-852.
DownloadGray PA, Rekling JC, Bocchiaro CM, Feldman JL   Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBotzinger complex Science, 1999; 286: 1566-1568.
DownloadRekling JC, Feldman JL   PreBötzinger Complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation Annual Review of Physiology, 1998; 60: 385-405.
DownloadSmith JC, Ellenberger HH, Ballanyi K, Richter DW, Feldman JL   PreBötzinger Complex: A brain region that may generate respiratory rhythm in mammals, Science, 1991; 254: 726-729.
DownloadFeldman Jack L, Kam Kaiwen   Facing the challenge of mammalian neural microcircuits: taking a few breaths may help The Journal of physiology, 2015; 593(1): 3-23.Sherman David, Worrell Jason W, Cui Yan, Feldman Jack L   Optogenetic perturbation of preBötzinger complex inhibitory neurons modulates respiratory pattern Nature neuroscience, 2015; 18(3): 408-14.Huckstepp Robert T R, Cardoza Kathryn P, Henderson Lauren E, Feldman Jack L   Role of parafacial nuclei in control of breathing in adult rats The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015; 35(3): 1052-67.Feldman Jack L, Kam Kaiwen   Facing the challenge of mammalian neural microcircuits: Taking a few breaths may help The Journal of physiology, 2014; 35(3): .Dick T E, Dutschmann M, Feldman J L, Fong A Y, Hülsmann S, Morris K M, Ramirez J M, Smith J C, Smith J C   Facts and challenges in respiratory neurobiology Respiratory physiology & neurobiology, 2015; 54(19): .Morgado-Valle Consuelo, Feldman Jack L   Depletion of substance P and glutamate by capsaicin blocks respiratory rhythm in neonatal rat in vitro The Journal of physiology, 2004; 555(Pt 3): 783-92.Mellen Nicholas M, Milsom William K, Feldman Jack L   Hypothermia and recovery from respiratory arrest in a neonatal rat in vitro brain stem preparation American journal of physiology. Regulatory, integrative and comparative physiology, 2002; 282(2): R484-91.Huckstepp Robert Tr, Henderson Lauren E, Cardoza Kathryn P, Feldman Jack L   Interactions between respiratory oscillators in adult rats eLife, 2016; 5: .

Li Peng, Janczewski Wiktor A, Yackle Kevin, Kam Kaiwen, Pagliardini Silvia, Krasnow Mark A, Feldman Jack L   The peptidergic control circuit for sighing Nature, 2016; 530(7590): 293-7.

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